Effect of vitamin D deficiency during pregnancy on offspring bone structure and quality

SAT-395 Correlations Between Biochemical Parameters and Trabecular Bone Score (TBS) in Primary Hyperparathyroidism (PHP) Patients

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.1960 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Lívia Marcela Santos ◽

Monique Nakayama Ohe ◽

Sthefanie Giovanna Pallone ◽

Ilda Sizue Kunii ◽

Renata Elen Costa Silva ◽

...

Keyword(s):

Vitamin D ◽

Trabecular Bone ◽

Vitamin D Deficiency ◽

Negative Correlation ◽

Bone Structure ◽

Trabecular Bone Score ◽

Control Group ◽

Total Calcium ◽

Mineral Density ◽

Positive Correlation

Abstract Background: Vitamin D deficiency is common among PHP patients. While data are limited, some studies suggest that vitamin D deficiency may exacerbates skeletal disease in PHP. TBS is a software-based method for assessment of trabecular bone structure of the spine, based on analysis of pixels obtained in dual energy x-ray absorptiometry (DXA) images. The aim of this study was to evaluate TBS, vitamin D status, clinical and laboratorial measurements in a PHP group of patients in a search for a more accurate bone fragility test for risk assessment in this group of patients. Methods: From June/2017 to January/2019, patients who met the criteria for PHP diagnosis were included in this study. Control group was composed by age and sex-matched healthy individuals. Overall, 64 PHP and 63 controls were enrolled. Bone mineral density (BMD) measured by DXA (Hologic QDR 4500) at the lumbar spine, total hip, femoral neck, and TBS values (InSight™) were determined in both groups. Total and ionized calcium, PTH, 25-hydroxyvitamin D (25(OH)D), creatinine, alkaline phosphatase, P1NP and CTX were measured. None were in use of Vitamin D supplementation. Results: As expected, PHP patients had lower BMD values than controls in all sites (p<0.0001). TBS measurements were also reduced in PHP patients compared to controls (1233 vs 1280, p=0.0444). TBS values were inversely correlated with total calcium (CaT) and phosphorus measurements were positively correlated in the PHP patients. 25(OH)D measurements didn’t differ between groups (PHP 22.5 vs. controls 19.8 ng/mL, p=0.1699). There was a positive correlation between 25(OH)D and TBS in both PHP and controls (r= 0,3088, p= 0,0138 and r= 0,3708, p= 0,003 respectively). Considering individuals with vitamin D deficiency (25(OH)D levels <=20 ng/mL), a negative correlation between TBS and CaT measurements among PHP patients (r= -0,4391, p=0,0172) was observeed, while in controls there was a positive correlation between TBS and 25(OH)D (r= 0,3504, p= 0,0362). Conclusion: Serum total calcium presents negative correlation and phosphorus a positive one with TBS in PHP patients. We also found a correlation between TBS and 25(OH)D, both in PHP and in controls. 25(OH)D <=20 ng/mL is an independent risk factor determining degraded TBS among PHP patients and controls.

Download Full-text

Long-term vitamin D deficiency in older adult C57BL/6 mice does not affect bone structure, remodeling and mineralization

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2015.09.004 ◽

2016 ◽

Vol 164 ◽

pp. 344-352 ◽

Cited By ~ 6

Author(s):

K. van der Meijden ◽

J. Buskermolen ◽

H.W. van Essen ◽

T. Schuurman ◽

W.T Steegenga ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Older Adult ◽

Bone Structure

Download Full-text

Effect of vitamin D deficiency during pregnancy on offspring bone structure, composition and quality in later life

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174412000542 ◽

2012 ◽

Vol 4 (1) ◽

pp. 49-55 ◽

Cited By ~ 7

Author(s):

S. A. Lanham ◽

C. Roberts ◽

A. K. Habgood ◽

S. Alexander ◽

T. H. J. Burne ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Elemental Analysis ◽

Bone Structure ◽

Later Life ◽

Sprague Dawley ◽

Micro Computed Tomography ◽

Skeletal Health ◽

Foetal Development ◽

Vitamin D Levels

During foetal development, calcium requirements are met as a consequence of maternal adaptations independent of vitamin D status. In contrast, after birth, dependency on vitamin D appears necessary for calcium metabolism and skeletal health. We used a rodent model (Sprague-Dawley rats), to determine if maternal vitamin D deficiency during pregnancy had a deleterious effect on bone structure at birth. Vitamin D deplete females were maintained under deplete conditions until birth of the pups, whereupon all dams were fed a vitamin D replete diet. Offspring were harvested at birth, and 140 days of age. Bones were analyzed using micro-computed tomography and strength tested to study differences in bone structure, density and strength and subjected to elemental analysis using plasma mass spectrometry to determine strontium, barium and calcium contents. Offspring from deplete mothers displayed altered trabecular parameters in the femur at birth and 140 days of age. In addition, at 140 days of age there was evidence of premature mineralization of the secondary ossification centre of the femoral head. Elemental analysis showed increased strontium uptake in the femur of the developmentally vitamin D-deficient offspring. Vitamin D depletion during development in the offspring may have a long-lasting effect, despite repletion of vitamin D from birth. This may have consequences for human health given the low vitamin D levels seen during pregnancy and current lifestyle of sun avoidance due to the risk of skin cancer.

Download Full-text

THE EFFECT OF ESTRADIOL BENZOATE AND CORN OIL ON BONE STRUCTURE OF GROWING COCKERELS EXPOSED TO VITAMIN-D DEFICIENCY

Endocrinology ◽

10.1210/endo-55-5-686 ◽

1954 ◽

Vol 55 (5) ◽

pp. 686-695 ◽

Cited By ~ 3

Author(s):

WALTER LANDAUER

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Structure ◽

Corn Oil ◽

Estradiol Benzoate

Download Full-text

BONE STRUCTURE AND METABOLISM IN CALCIUM-DEFICIENT RATS

Journal of Endocrinology ◽

10.1677/joe.0.0210197 ◽

1960 ◽

Vol 21 (2) ◽

pp. 197-205 ◽

Cited By ~ 80

Author(s):

M. HARRISON ◽

RUSSELL FRASER

Keyword(s):

Vitamin D ◽

Bone Resorption ◽

Bone Formation ◽

Vitamin D Deficiency ◽

Bone Structure ◽

Calcium Deficiency ◽

Bone Atrophy ◽

Structure And Metabolism

SUMMARY Pure calcium deficiency produces osteoporosis, or bone atrophy, in rats, while vitamin D deficiency as well as calcium deficiency leads to osteomalacia, or thin bones with wide osteoid seams. The retention of a dose of strontium in the osteoporotic rats is greater than normal, and this indicates rapid bone formation. The immediate cause of the bone thinning must therefore be an increase in the rate of bone resorption, contrary to the classical concepts of osteoporosis.

Download Full-text