Longitudinal changes in bone mass in children with cystic fibrosis: Effect of size adjustment using Bone Mineral Apparent Density (BMAD)

Bone ◽  
2009 ◽  
Vol 45 ◽  
pp. S93
Author(s):  
J.E. Williams ◽  
A. Jaffe ◽  
R. Suri ◽  
N.J. Crabtree ◽  
M.S. Fewtrell
Keyword(s):  
Cystic Fibrosis ◽  
Bone Mass ◽  
Bone Mineral ◽  
Apparent Density ◽  
Bone Mineral Apparent Density ◽  
Longitudinal Changes ◽  
Size Adjustment

scholarly journals Cross-sectional and Longitudinal Evaluation of Bone Mass in Children and Young Adults with Juvenile Idiopathic Arthritis: The Role of Bone Mass Determinants in a Large Cohort of Patients

2010 ◽  
Vol 37 (9) ◽  
pp. 1935-1943 ◽  
Author(s):  
STEFANO STAGI ◽  
LAURA MASI ◽  
SERENA CAPANNINI ◽  
ROLANDO CIMAZ ◽  
GIULIA TONINI ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Bone Mass ◽  
Bone Mineral ◽  
Large Cohort ◽  
Close Monitoring ◽  
Mineral Density ◽  
Cross Sectional ◽  
Bone Mineral Apparent Density ◽  
Longitudinal Evaluation ◽  
Enthesitis Related Arthritis

Objective.To assess the prevalence of reduced spine bone mineral apparent density (BMAD), and to identify the main predictors of reduced spine BMAD in a cross-sectional and longitudinal evaluation of the same large cohort of patients with juvenile idiopathic arthritis (JIA). There are few prospective data on bone mass evaluation in a large number of patients with JIA, and with enthesitis-related arthritis onset.Methods.Two hundred nineteen patients with JIA (median age 8.7 yrs, range 6.1–13.1 yrs; 104 oligoarticular JIA, 61 polyarticular, 20 systemic, and 34 enthesitis-related arthritis onset) were retrospectively evaluated. A dual-energy x-ray absorptiometry (DEXA) scan at the lumbar spine was performed in all subjects. Of these, 89 consecutive patients were followed up randomly and longitudinally with a second and a third DEXA evaluation. The data obtained were compared with 80 age-matched and sex-matched healthy subjects.Results.At the first DEXA, patients with JIA showed a reduced spine BMAD standard deviation score (SDS) in comparison to controls (p < 0.001). These results were confirmed when the subjects were divided into JIA subtypes (p < 0.005) with the exception of enthesitis-related arthritis onset. Spine BMAD SDS significantly correlated with JIA onset type (p < 0.01), age at JIA onset (p < 0.005), and flares (p = 0.008). The longitudinal evaluation showed that spine BMAD SDS did not significantly improve at the followup in comparison to controls, in all subsets with JIA except for systemic onset (p < 0.05). Spine BMAD correlated with sex (p < 0.01), systemic corticosteroid exposure (p < 0.01), the number of intraarticular corticosteroid injections (p < 0.01), the interval from last steroid injection (p < 0.05), erythrocyte sedimentation rate (p < 0.005), and C-reactive protein levels (p < 0.005).Conclusion.Patients with JIA have a low bone mass and, after a first increase due to therapy, do not reach a healthy condition over time despite our current more effective drugs. These patients have a high risk of osteoporosis in early adulthood. To reduce the risk and improve the bone mass, close monitoring of bone mineral density, better control of disease activity, physical activity, and intake of calcium and vitamin D are recommended. In patients with osteoporosis, therapeutic approaches including bisphosphonates should be considered.

Does Bone Mineral Apparent Density Predict Osteoporotic Fractures in Lebanese Postmenopausal Women?

2014 ◽  
Vol 17 (3) ◽  
pp. 423
Author(s):  
R. El Hage ◽  
A. Sebaaly ◽  
M. Issa ◽  
F. Bachour ◽  
E. Zakhem ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Bone Mineral ◽  
Apparent Density ◽  
Osteoporotic Fractures ◽  
Bone Mineral Apparent Density

scholarly journals Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Andrea Trombetti ◽  
Laura Richert ◽  
François R. Herrmann ◽  
Thierry Chevalley ◽  
Jean-Daniel Graf ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Apparent Density ◽  
Proximal Femur ◽  
Control Group ◽  
Adult Women ◽  
Mineral Density ◽  
Hip Geometry ◽  
Bone Mineral Apparent Density

We investigated the relative effect of amenorrhea and insulin-like growth factor-I (sIGF-I) levels on cancellous and cortical bone density and size. We investigated 66 adult women with anorexia nervosa. Lumbar spine and proximal femur bone mineral density was measured by DXA. We calculated bone mineral apparent density. Structural geometry of the spine and the hip was determined from DXA images. Weight and BMI, but not height, as well as bone mineral content and density, but not area and geometry parameters, were lower in patients with anorexia nervosa as compared with the control group. Amenorrhea, disease duration, and sIGF-I were significantly associated with lumbar spine and proximal femur BMD. In a multiple regression model, we found that sIGF-I was the only significant independent predictor of proximal femur BMD, while duration of amenorrhea was the only factor associated with lumbar spine BMD. Finally, femoral neck bone mineral apparent density, but not hip geometry variables, was correlated with sIGF-I. In anorexia nervosa, spine BMD was related to hypogonadism, whereas sIGF-I predicted proximal femur BMD. The site-specific effect of sIGF-I could be related to reduced volumetric BMD rather than to modified hip geometry.

scholarly journals Bone density and metabolism in subjects with microdeletion of chromosome 22q11 (del22q11)

2010 ◽  
Vol 163 (2) ◽  
pp. 329-337 ◽  
Author(s):  
Stefano Stagi ◽  
Elisabetta Lapi ◽  
Eleonora Gambineri ◽  
Cristina Manoni ◽  
Maurizio Genuardi ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Mineral ◽  
Young Patients ◽  
Serum Levels ◽  
Close Monitoring ◽  
Total Calcium ◽  
Mineral Density ◽  
Bone Mineral Apparent Density ◽  
Bone Specific Alkaline Phosphatase ◽  
Chromosome 22Q11

IntroductionAlthough hypoparathyroidism with hypocalcaemia is one of the most frequent clinical features of monoallelic microdeletion of chromosome 22q11 (22q11DS), bone mass and metabolism have not yet been assessed in these patients.DesignThis study aimed to evaluate bone mass and metabolism in a cohort of patients, both children and adults, with 22q11DS.MethodsIn twenty-eight patients with 22q11DS (median age 12.5, range 6.1–42.8 years), serum levels of ionised and total calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, osteocalcin and bone-specific alkaline phosphatase (BSAP), and urinary deoxypyridinoline concentrations were evaluated. In these patients, bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DXA) examination, and volumetric BMD (bone mineral apparent density (BMAD)) was calculated.The data obtained from paediatric and adult patients were compared with two age-, sex- and body size-matched healthy subject control groups.ResultsPatients with 22q11DS showed a reduced BMAD Z-score compared with controls (P<0.001). These patients also had significantly lower ionised (P<0.001) and total calcium (P<0.05) levels as well as lower PTH levels (P<0.05), compared with the controls. In particular, children and young patients with 22q11DS had significantly lower serum osteocalcin levels (P<0.001), BSAP levels (P<0.001) and urinary deoxypyridinoline concentrations (P<0.001) than controls. These results were not confirmed in adults.Finally, patients with hypoparathyroidism and/or hypocalcaemia at the time of the study showed significantly lower ionised (P<0.001) and total calcium levels (P<0.001), PTH levels (P<0.05), BSAP levels (P<0.001), osteocalcin levels (P<0.001) and urinary deoxypyridinoline concentrations (P<0.001), compared with patients without hypoparathyroidism and/or hypocalcaemia. Nonetheless, the BMAD Z-score did not show substantial differences between these two groups.ConclusionsSubjects with 22q11DS have a significant reduction in bone mass that appears to be more severe in adults who have already attained peak bone mass than in children who are still growing. Therefore, we suggest a close monitoring of bone mass and metabolism in 22q11DS patients.

Bone mineral apparent density in juvenile dermatomyositis: the role of lean body mass and glucocorticoid use

2008 ◽  
Vol 37 (1) ◽  
pp. 40-47 ◽  
Author(s):  
R. A. Santiago ◽  
C. A. A. Silva ◽  
V. F. Caparbo ◽  
A. M. E. Sallum ◽  
R. M. R. Pereira
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Apparent Density ◽  
Juvenile Dermatomyositis ◽  
Bone Mineral Apparent Density
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