scholarly journals Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Andrea Trombetti ◽  
Laura Richert ◽  
François R. Herrmann ◽  
Thierry Chevalley ◽  
Jean-Daniel Graf ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Apparent Density ◽  
Proximal Femur ◽  
Control Group ◽  
Adult Women ◽  
Mineral Density ◽  
Hip Geometry ◽  
Bone Mineral Apparent Density

We investigated the relative effect of amenorrhea and insulin-like growth factor-I (sIGF-I) levels on cancellous and cortical bone density and size. We investigated 66 adult women with anorexia nervosa. Lumbar spine and proximal femur bone mineral density was measured by DXA. We calculated bone mineral apparent density. Structural geometry of the spine and the hip was determined from DXA images. Weight and BMI, but not height, as well as bone mineral content and density, but not area and geometry parameters, were lower in patients with anorexia nervosa as compared with the control group. Amenorrhea, disease duration, and sIGF-I were significantly associated with lumbar spine and proximal femur BMD. In a multiple regression model, we found that sIGF-I was the only significant independent predictor of proximal femur BMD, while duration of amenorrhea was the only factor associated with lumbar spine BMD. Finally, femoral neck bone mineral apparent density, but not hip geometry variables, was correlated with sIGF-I. In anorexia nervosa, spine BMD was related to hypogonadism, whereas sIGF-I predicted proximal femur BMD. The site-specific effect of sIGF-I could be related to reduced volumetric BMD rather than to modified hip geometry.

scholarly journals Teriparatide Increases Bone Formation and Bone Mineral Density in Adult Women With Anorexia Nervosa

2014 ◽  
Vol 99 (4) ◽  
pp. 1322-1329 ◽  
Author(s):  
Pouneh K. Fazeli ◽  
Irene S. Wang ◽  
Karen K. Miller ◽  
David B. Herzog ◽  
Madhusmita Misra ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Anorexia Nervosa ◽  
Bone Formation ◽  
Bone Mineral ◽  
Adult Women ◽  
Mineral Density

Bone Mineral Density Assessment by DXA vs. QCT in Postmenopausal Females with Central Obesity

2020 ◽  
Vol 13 (2) ◽  
pp. 153-161
Author(s):  
Lejla Milisic ◽  
Sandra Vegar-Zubovic ◽  
Amina Valjevac ◽  
Suada Hasanovic-Vučković
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Central Obesity ◽  
Quantitative Computed Tomography ◽  
Normal Weight ◽  
Mineral Density ◽  
Cross Sectional ◽  
T Score

Objectives: Although Dual-energy X-ray Absorptiometry (DXA) is gold standard for osteoporosis diagnosis, several reports have shown discordant T-score values measured by Quantitative Computed Tomography (QCT) and DXA especially in obese subjects, but it is still not clear whether BMD measurement by two modalities is affected by overall obesity or central obesity in postmenopausal females. Therefore, the aims of this study were to compare BMD and T-scores by DXA and QCT and to evaluate whether these two osteoporosis assessment modalities yield different T-score values in postmenopausal females with obesity and central obesity. Methods: This cross-sectional study enrolled 44 postmenopausal females, referred for osteoporosis screening. Anthropometric indices (BMI-body mass index, WC-waist circumference and ICOindex of central obesity) were measured and females underwent an assessment of bone mineral density by DXA and QCT. Results: Lumbar Spine (LS) T-score values were observed to be significantly lower by DXA compared to qCT in females with BMI >25 kg/m2, (-1.9±1.5 vs. -2.3±1.2; p=0.039), in females with WC>88 cm(-1.9±1.5 vs. -2.4±1.2; p=0.008) and in females with ICO>0.5(-1.96±1.4 vs. -2.5±1.2; p=0.004). However, in normal-weight females and in those without central obesity, LS T-scores by DXA were not different than qCT. DXA at lumbar spine and proximal femur revealed osteoporosis in 47.7% and 11.4% respectively, while QCT detected osteoporosis in 61.4% of females (p<0.001). Measures of central obesity; ICO and WC were not associated with QCT bone mineral density (BMD) (r=0.14 and r=0.21, respectively), but were positively associated with both DXALS BMD (r=0.29 and r=0.31; p<0.05) and DXA proximal femur BMD (r=0.41 and r=0.44; p<0.01). Conclusion: Our results suggest that obesity is associated with lower T-scores by DXA compared to QCT. Caution is needed when assessing osteoporosis status in obese postmenopausal females. However, further studies with larger sample size are needed to confirm the findings.

Bone mineral density of lumbar spine and proximal femur in healthy males

2004 ◽  
Vol 259 (2) ◽  
pp. 361-364 ◽  
Author(s):  
S. Akin ◽  
S. Isikli ◽  
F. Korkusuz ◽  
M. Ungan ◽  
A. Senkoylu
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Mineral Density ◽  
Healthy Males

scholarly journals Effects of Dried Plum (Prunes) on Bone Density and Strength in Men

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 21-21
Author(s):  
Jonnatan Fajardo ◽  
Danielle Gaffen ◽  
Ashley Eisner ◽  
Mark Kern ◽  
Shirin Hooshmand
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Human Study ◽  
Control Group ◽  
Adult Women ◽  
Protective Effects ◽  
Mineral Density ◽  
Total Body ◽  
The Impact

Abstract Objectives Traditionally, osteoporosis has been viewed as a disease mostly affecting women, but cases in men are increasing. Fractures due to osteoporosis can lead to a decreased quality of life in vulnerable populations and lead to increased mortality in men. Although several studies of male and female animals and adult women have demonstrated bone protective effects of dried plum (prunes), no human study has evaluated the effect of dried plum on bone health in men. The objective of the current study was to examine the long-term effects of 100 g dried plum on bone density and strength in men. Methods Sixty-six men (50–79 years old) were randomly assigned into two treatment groups for 12 months: (1) 100 g/day of dried plums; (2) control (0 g/day dried plum). Bone mineral density was measured at baseline, 6- and 12-months at the total body, hip, lumbar spine, and ulna via dual-energy x-ray absorptiometry (DXA). Evaluation of volumetric bone density and strength of the left tibia occurred at baseline, 6- and 12-months using peripheral quantitative computed tomography (pQCT). Results There were no statistically significant changes in bone mineral density (BMD) from baseline to 6 months and 12 months for total body, spine (L1-L4), right and left hip BMD in the control group (0 g/day dried plum) or 100 g/day dried plum group. Modest beneficial effects of dried plums were observed for changes in bone geometry as detected by pQCT including a tendency for BMD to increase as well as increases in periosteal and endosteal circumferences at the 66% region of the tibia, which may promote greater bone strength. Conclusions Dried plums have the potential to improve bone morphometry of the proximal tibia in healthy adult men when consumed for 12 months. Future studies should examine the impact on men with low bone density to further evaluate the bone protective effects of dried plum in male populations. Funding Sources This study was funded by the California Dried Plum Board.

BONE MINERAL DENSITY WOMEN AGED 45 AND OLDER WITH OVERWEIGHT AND OBESITY

2018 ◽  
pp. 109-113
Author(s):  
Ngoc Giang Luu ◽  
Anh Thu Le ◽  
Hai Thuy Nguyen
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Overweight And Obesity ◽  
Control Group ◽  
Mineral Density ◽  
Femoral Bone Mineral Density ◽  
Cross Sectional ◽  
Osteoporosis Risk Factors ◽  
Key Words Bone

Objectives: (1) To assess the bone mineral density by dual energy X-ray absorptiometry in women aged 45 and older with overweight, obesity. (2) To approach the relationship between the bone mineral density and osteoporosis risk factors in women aged 45 and older with overweight, obesity. Materials and method: 207 women aged 45 and older receiving treatment at Medic - Binh Duong hospital were divided into 2 groups: 147 women with overweight, obesity and 60 women without overweight, obesity. Research was designed as a cross-sectional descriptive study and comparative control group. Results: The femoral bone mineral density in terms of women with overweight, obesity is (0.795 ± 0.121) and the control group is (0.731± 0.116). The bone mineral density of lumbar spine in women with overweight, obesity is (0.800 ± 0.138) and the control group is (0.757 ± 0.148). Conclusions: The bone mineral of femora in women with overweight, obesity was higher than that of the control group (p<0.05). Between two groups, there were no differences in the bone mineral of lumbar spine (p>0.05). There was a statistically significant relationship between the bone mineral density and age, menopause state, and duration of menopause in women aged 45 and older with overweight, obesity (p<0.01). Key words: Bone mineral density, women aged 45 and older, overweight, obesity

scholarly journals Sex Hormone Status May Modulate Rate of Expansion of Proximal Femur Diameter in Older Women alongside Other Skeletal Regulators

2007 ◽  
Vol 92 (1) ◽  
pp. 304-313 ◽  
Author(s):  
S. Kaptoge ◽  
N. Dalzell ◽  
E. Folkerd ◽  
D. Doody ◽  
K.-T. Khaw ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Proximal Femur ◽  
Sex Hormone ◽  
Vitamin D Metabolites ◽  
Mineral Density ◽  
Hip Geometry ◽  
Cross Sectional ◽  
Narrow Neck ◽  
Section Modulus ◽  
Hormone Status

Abstract Context: Little is known of associations between hip geometry and skeletal regulators. This is important because geometry is a determinant of both hip function and resistance to fracture. Objective: We aimed to determine the effects of sex hormone status and other candidate regulators on hip geometry and strength. Subjects and Methods: A random sample of 351 women aged 67–79 had two to four hip dual-energy x-ray absorptiometry scans performed over 8 yr of follow-up. Hip structural analysis software was used to measure subperiosteal diameter (PD) and the distance from the center of mass to the lateral cortical margin (d-lat) on three 5-mm-thick cross-sectional regions: narrow neck, intertrochanter, and shaft. Section modulus (Z), bone mineral density (grams per centimeter squared), and an index of bone mineral content (cross-sectional area) were calculated as estimators of bone strength. Serum analytes measured at baseline included SHBG, estradiol, PTH, creatinine, albumin, vitamin D metabolites, and glutamate- and γ-carboxyglutamate-osteocalcin (OC). A linear mixed model was used to model associations with predictor variables, including testing whether the predictors significantly modified the effect of aging. Results: Aging was associated with increasing PD and d-lat, and higher baseline SHBG significantly modified this effect, in the case of PD, increasing the rates of change at the narrow neck region by 19% for SHBG level 2 sd higher than population mean (P = 0.026). Higher baseline creatinine was independently associated with faster increases in PD and d-lat with aging (P &lt; 0.041). Z declined faster with aging if baseline PTH was higher, and higher albumin had a contrary effect. Z was positively associated with free estradiol and inversely associated with SHBG and glutamate-OC. Conclusion: These results show large effects of SHBG on the regulation of proximal femur expansion and bending resistance, probably acting as a surrogate for low bioavailable estrogen. Potentially important effects for fracture resistance in old age were also revealed for PTH, markers related to renal function and the nutritional markers albumin and undercarboxylated OC.

Factors associated with the lumbar spine and proximal femur bone mineral density in older men

2005 ◽  
Vol 16 (12) ◽  
pp. 1525-1537 ◽  
Author(s):  
Jane A. Cauley ◽  
Robin L. Fullman ◽  
Katie L. Stone ◽  
Joseph M. Zmuda ◽  
Douglas C. Bauer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Older Men ◽  
Mineral Density ◽  
Factors Associated ◽  
Femur Bone
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