Dose dependent anabolic and anti-catabolic response after local zoledronate treatment of cancellous bone grafts A bone chamber study in rats

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S140
Author(s):  
M. Tägil ◽  
O. Belfrage
Keyword(s):  
Cancellous Bone ◽  
Bone Grafts ◽  
Chamber Study ◽  
Catabolic Response ◽  
Dose Dependent

Deep-Frozen Allogeneic Cancellous Bone Grafts in 10 Dogs: A Case Series

1996 ◽  
Vol 25 (1) ◽  
pp. 18-28 ◽  
Author(s):  
SHARON C. KERWIN ◽  
DANIEL D. LEWIS ◽  
A. DERRELL ELKINS ◽  
JULIAN OLIVER ◽  
ROBERT PECHMAN ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Case Series ◽  
Bone Grafts

Autogeneic Cancellous Bone Grafts in Extensive Segmental Ulnar Defects in Dogs

1989 ◽  
Vol &NA; (243) ◽  
pp. 254???265
Author(s):  
E. E. JOHNSON ◽  
M. R. URIST ◽  
T. P. SCHMALZRIED ◽  
A. CHOTIVICHIT ◽  
H. K. HUANG ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Bone Grafts

Qualitative aspects of the incorporation of equine cancellous bone grafts

1987 ◽  
Vol 19 (2) ◽  
pp. 111-119 ◽  
Author(s):  
S. E. KOLD ◽  
J. HICKMAN ◽  
F. MELSEN
Keyword(s):  
Cancellous Bone ◽  
Bone Grafts

scholarly journals Androstenedione treatment reduces loss of cancellous bone volume in ovariectomised rats in a dose-responsive manner and the effect is not mediated by oestrogen

1998 ◽  
Vol 156 (2) ◽  
pp. 331-339 ◽  
Author(s):  
CK Lea ◽  
V Moxham ◽  
MJ Reed ◽  
AM Flanagan
Keyword(s):  
Bone Turnover ◽  
Cancellous Bone ◽  
Plasma Concentrations ◽  
Significant Degree ◽  
Bone Volume ◽  
Simultaneous Treatment ◽  
Ovx Rats ◽  
Dose Dependent Fashion ◽  
A Minor ◽  
Dose Dependent

We have tested the hypothesis that androstenedione (administered as 21-day, slow-release pellets) is converted to active sex steroids and reduces bone turnover in the ovariectomised rat model. We found that ovariectomy resulted in a minor but significant reduction in plasma concentrations of androstenedione and testosterone and a more significant reduction in oestrone (E1) and oestradiol (E2). This was associated with the expected substantial loss of metaphyseal cancellous bone volume. Androstenedione (1.5-100 mg) pellets increased the plasma concentrations of androstenedione and testosterone above those in the ovariectomised (ovx) rats in a dose-responsive manner, whereas E2 plasma concentrations were increased to a minor but significant degree above those in the ovx animals. Androstenedione reduced loss of cancellous bone volume in a dose-dependent fashion by reducing bone turnover. The 1.5, 5 and 100 mg androstenedione-induced effect on bone turnover was not abrogated by simultaneous treatment with Arimidex, an aromatase inhibitor. This implies that the skeletal-protective effect of androstenedione was not oestrogen-mediated.

Evaluation of Acellular Bovine Cancellous Bone Matrix Seeded with Foetal Rabbit Osteoblasts for Segmental Bone Defects in Rabbits

2020 ◽  
Author(s):  
Rashmi Rashmi ◽  
Rekha Pathak ◽  
P. Tamilmahan ◽  
Amarpal Amarpal ◽  
H. P. Aithal ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Bone Matrix ◽  
Bone Grafts ◽  
Composite Graft ◽  
Matrix Group ◽  
Composite Grafts ◽  
Group A ◽  
Segmental Bone ◽  
Group B ◽  
Composite Bone

The present work was assessed the restoration of segmental bone gap defect in rabbits by application of composite bone grafts. Composite bone grafts were prepared by seeding of rabbit foetal osteoblast on the bovine acellular cancellous bone matrix and evaluated in the segmental gap defect of 20 mm in rabbits. Thirty six adult New Zealand White rabbits of either sex were allotted to three groups of 12 each. Autograft (group A), Acellular cancellous bone matrix (group B) and composite graft seeded with fetal osteoblasts (group C) were implanted in the defects. Radiography, gross observations and histopathology at different intervals were done to evaluate healing. It was concluded that the seeded foetal osteoblasts in the composite grafts augment regeneration of the new bone leading to better integration of graft in host in comparison to bovine acellular cancellous bone matrix graft.

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