Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both bone formation and bone density. A bone chamber study in rats

Bone ◽  
2008 ◽  
Vol 42 ◽  
pp. S45
Author(s):  
Ola Belfrage ◽  
Uldis Kesteris ◽  
Magnus Tägil
Keyword(s):  
Bone Density ◽  
Bone Formation ◽  
Cancellous Bone ◽  
Local Treatment ◽  
Bone Grafts ◽  
Chamber Study

scholarly journals Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density

2011 ◽  
Vol 82 (2) ◽  
pp. 228-233 ◽  
Author(s):  
Ola Belfrage ◽  
Gunnar Flivik ◽  
Martin Sundberg ◽  
Uldis Kesteris ◽  
Magnus Tägil
Keyword(s):  
Bone Density ◽  
Bone Formation ◽  
Cancellous Bone ◽  
Formation Rate ◽  
Local Treatment ◽  
Bone Grafts ◽  
Bone Formation Rate

scholarly journals Ibudilast Mitigates Delayed Bone Healing Caused by Lipopolysaccharide by Altering Osteoblast and Osteoclast Activity

2021 ◽  
Vol 22 (3) ◽  
pp. 1169
Author(s):  
Yuhan Chang ◽  
Chih-Chien Hu ◽  
Ying-Yu Wu ◽  
Steve W. N. Ueng ◽  
Chih-Hsiang Chang ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bone Formation ◽  
Cancellous Bone ◽  
Bone Healing ◽  
Bone Bridge ◽  
Cell Wall Components ◽  
Osteoclast Activity ◽  
Wall Components

Bacterial infection in orthopedic surgery is challenging because cell wall components released after bactericidal treatment can alter osteoblast and osteoclast activity and impair fracture stability. However, the precise effects and mechanisms whereby cell wall components impair bone healing are unclear. In this study, we characterized the effects of lipopolysaccharide (LPS) on bone healing and osteoclast and osteoblast activity in vitro and in vivo and evaluated the effects of ibudilast, an antagonist of toll-like receptor 4 (TLR4), on LPS-induced changes. In particular, micro-computed tomography was used to reconstruct femoral morphology and analyze callus bone content in a femoral defect mouse model. In the sham-treated group, significant bone bridge and cancellous bone formation were observed after surgery, however, LPS treatment delayed bone bridge and cancellous bone formation. LPS inhibited osteogenic factor-induced MC3T3-E1 cell differentiation, alkaline phosphatase (ALP) levels, calcium deposition, and osteopontin secretion and increased the activity of osteoclast-associated molecules, including cathepsin K and tartrate-resistant acid phosphatase in vitro. Finally, ibudilast blocked the LPS-induced inhibition of osteoblast activation and activation of osteoclast in vitro and attenuated LPS-induced delayed callus bone formation in vivo. Our results provide a basis for the development of a novel strategy for the treatment of bone infection.

Primary cancellous bone formation with BMP and micro-chambered beads

Bone ◽  
2013 ◽  
Vol 52 (1) ◽  
pp. 465-473 ◽  
Author(s):  
M.E. Draenert ◽  
K.-H. Kunzelmann ◽  
F. Forriol ◽  
R. Hickel ◽  
K. Draenert
Keyword(s):  
Bone Formation ◽  
Cancellous Bone

Deep-Frozen Allogeneic Cancellous Bone Grafts in 10 Dogs: A Case Series

1996 ◽  
Vol 25 (1) ◽  
pp. 18-28 ◽  
Author(s):  
SHARON C. KERWIN ◽  
DANIEL D. LEWIS ◽  
A. DERRELL ELKINS ◽  
JULIAN OLIVER ◽  
ROBERT PECHMAN ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Case Series ◽  
Bone Grafts
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