Loss of function of the non-genomic estrogen receptor GPR30 causes increased body size, percent body fat, and bone mass in adult male mice

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S62-S63
Author(s):  
J. Ford ◽  
A. Hajibeigi ◽  
M. Getachew ◽  
J. Liu ◽  
D. Clegg ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Body Size ◽  
Bone Mass ◽  
Body Fat ◽  
Adult Male ◽  
Percent Body Fat ◽  
Male Mice ◽  
Loss Of Function

Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age

Bone ◽  
2000 ◽  
Vol 27 (2) ◽  
pp. 203-207 ◽  
Author(s):  
H.A Weiler ◽  
L Janzen ◽  
K Green ◽  
J Grabowski ◽  
M.M Seshia ◽  
...  
Keyword(s):  
Bone Mass ◽  
Body Fat ◽  
Percent Body Fat

scholarly journals The androgen receptor is required for maintenance of bone mass in adult male mice

2019 ◽  
Vol 479 ◽  
pp. 159-169 ◽  
Author(s):  
Jianyao Wu ◽  
Petra Henning ◽  
Klara Sjögren ◽  
Antti Koskela ◽  
Juha Tuukkanen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bone Mass ◽  
Adult Male ◽  
Male Mice

Body mass index, percent body fat, and bone mass in a cohort of Chinese twins aged 6 to 18 years

2007 ◽  
Vol 2 (1-2) ◽  
pp. 7-20
Author(s):  
Lester M. Arguelles ◽  
Xiaobin Wang ◽  
Binyan Wang ◽  
Hakan Demirtas ◽  
Jianhua Yang ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Bone Mass ◽  
Body Mass ◽  
Body Fat ◽  
Percent Body Fat ◽  
Chinese Twins

scholarly journals Measures of Obesity Associated with Asthma Diagnosis in Ethnic Minority Children

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Nita Vangeepuram ◽  
Susan L. Teitelbaum ◽  
Maida P. Galvez ◽  
Barbara Brenner ◽  
John Doucette ◽  
...  
Keyword(s):  
Body Size ◽  
Ethnic Minority ◽  
Body Fat ◽  
Fat Distribution ◽  
The Body ◽  
Percent Body Fat ◽  
Asthma Diagnosis ◽  
Minority Children ◽  
Study Objective ◽  
Ethnic Minority Children

Objective. The study objective was to examine relationships between different body size measurements and asthma in ethnic minority children.Methods. We used data from a community-based study of 505 children aged 6-to-8 years old to study the association of percent body fat, fat distribution, and BMI percentile with asthma diagnosis. Poisson regression models were used to compute prevalence ratios (PRs) for sex-specific quintiles of the body fat measures on the main outcome of asthma.Results. When comparing the highest quintile of each body fat measure to the combined lowest two quintiles, higher body mass index percentile, percent body fat, and waist circumference all were associated with a higher likelihood of physician-diagnosed asthma (PR = 1.63 (95% CI 1.12–2.39), 1.50 (95% CI 1.02–2.21), and 1.56 (95% CI 1.04–2.34), resp.).Conclusions. This study found a significant association between increased body size and asthma diagnosis, regardless of the measurement examined.

scholarly journals Effects of Short-Term Treatment with Estrogen Receptor Agonist on Morphological Changes in Reproductive Organs of Adult Male Mice

2016 ◽  
Vol 46 (4) ◽  
pp. 193-200
Author(s):  
Hayana Choi ◽  
Yun Jeong Mo ◽  
Mi-Kyung Lee ◽  
Eun Sang Choe ◽  
Sung Tae Yee ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Adult Male ◽  
Receptor Agonist ◽  
Morphological Changes ◽  
Reproductive Organs ◽  
Term Treatment ◽  
Male Mice ◽  
Short Term ◽  
Short Term Treatment

scholarly journals Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice

2022 ◽  
Vol 23 (2) ◽  
pp. 675
Author(s):  
Kimberly K. Richardson ◽  
Wen Ling ◽  
Kimberly Krager ◽  
Qiang Fu ◽  
Stephanie D. Byrum ◽  
...  
Keyword(s):  
Young Adult ◽  
Bone Resorption ◽  
Bone Loss ◽  
Ionizing Radiation ◽  
Bone Mass ◽  
Adult Male ◽  
Osteoclast Differentiation ◽  
Mitochondrial Activity ◽  
Male Mice ◽  
Young Adult Male

The damaging effects of ionizing radiation (IR) on bone mass are well-documented in mice and humans and are most likely due to increased osteoclast number and function. However, the mechanisms leading to inappropriate increases in osteoclastic bone resorption are only partially understood. Here, we show that exposure to multiple fractions of low-doses (10 fractions of 0.4 Gy total body irradiation [TBI]/week, i.e., fractionated exposure) and/or a single exposure to the same total dose of 4 Gy TBI causes a decrease in trabecular, but not cortical, bone mass in young adult male mice. This damaging effect was associated with highly activated bone resorption. Both osteoclast differentiation and maturation increased in cultures of bone marrow-derived macrophages from mice exposed to either fractionated or singular TBI. IR also increased the expression and enzymatic activity of mitochondrial deacetylase Sirtuin-3 (Sirt3)—an essential protein for osteoclast mitochondrial activity and bone resorption in the development of osteoporosis. Osteoclast progenitors lacking Sirt3 exposed to IR exhibited impaired resorptive activity. Taken together, targeting impairment of osteoclast mitochondrial activity could be a novel therapeutic strategy for IR-induced bone loss, and Sirt3 is likely a major mediator of this effect.

scholarly journals Testosterone and the Male Skeleton: A Dual Mode of Action

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Mieke Sinnesael ◽  
Steven Boonen ◽  
Frank Claessens ◽  
Evelien Gielen ◽  
Dirk Vanderschueren
Keyword(s):  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Bone Mass ◽  
Bone Turnover ◽  
Mode Of Action ◽  
Estrogen Receptor Alpha ◽  
Receptor Activation ◽  
Male Mice ◽  
Dual Mode ◽  
Receptor Alpha

Testosterone is an important hormone for both bone gain and maintenance in men. Hypogonadal men have accelerated bone turnover and increased fracture risk. In these men, administration of testosterone inhibits bone resorption and maintains bone mass. Testosterone, however, is converted into estradiol via aromatization in many tissues including male bone. The importance of estrogen receptor alpha activation as well of aromatization of androgens into estrogens was highlighted by a number of cases of men suffering from an inactivating mutation in the estrogen receptor alpha or in the aromatase enzyme. All these men typically had low bone mass, high bone turnover and open epiphyses. In line with these findings, cohort studies have confirmed that estradiol contributes to the maintenance of bone mass after reaching peak bone mass, with an association between estradiol and fractures in elderly men. Recent studies in knock-out mice have increased our understanding of the role of androgens and estrogens in different bone compartments. Estrogen receptor activation, but not androgen receptor activation, is involved in the regulation of male longitudinal appendicular skeletal growth in mice. Both the androgen and the estrogen receptor can independently mediate the cancellous bone-sparing effects of sex steroids in male mice. Selective KO studies of the androgen receptor in osteoblasts in male mice suggest that the osteoblast in the target cell for androgen receptor mediated maintenance of trabecular bone volume and coordination of bone matrix synthesis and mineralization. Taken together, both human and animal studies suggest that testosterone has a dual mode of action on different bone surfaces with involvement of both the androgen and estrogen receptor.

Measurement versus estimation of condition in snakes

1996 ◽  
Vol 74 (9) ◽  
pp. 1617-1621 ◽  
Author(s):  
Patrick J. Weatherhead ◽  
Gregory P. Brown
Keyword(s):  
Body Size ◽  
Body Mass ◽  
Body Fat ◽  
Lipid Extraction ◽  
Condition Index ◽  
Early Spring ◽  
Percent Body Fat ◽  
Total Body Mass ◽  
Conventional Condition ◽  
Water Snakes

Because variation in fat reserves (i.e., condition) is expected to contribute to variation in survival and reproductive success, zoologists often wish to estimate the condition of the animals they study. The conventional condition estimates used for snakes are the residuals from a regression of body mass on body length. Because this estimate of condition is not independent of the variables used to estimate it (i.e., fat is a component of body mass), estimates derived in this fashion will be confounded whenever fat varies nonrandomly with length. To avoid this problem we used total lipid extraction to estimate percent body fat in a representative sample of northern water snakes (Nerodia sipedon). The conventional condition index explained less than half the variance in the measured percent body fat in this sample. An improved estimate of condition calculated as the difference between total body mass and predicted lean mass (based on the results of the lipid extraction) explained 70% of the variation in percent body fat in the original sample of snakes. This improved estimate also revealed that condition declined with body size in a large sample of male water snakes measured in early spring over a 4-year period. This last result, coupled with theoretical expectations that condition will not vary randomly with body size in snakes, suggests that researchers interested in condition should derive indices from direct measurements of body fat.

1625: Role of Estrogen Receptor β in the Regulation of Sexual Behavior in Male Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 429-429
Author(s):  
Masayoshi Nomura ◽  
Naohiro Fujimoto ◽  
Donald W. Pfaff ◽  
Sonoko Ogawa ◽  
Tetsuro Matsumoto
Keyword(s):  
Estrogen Receptor ◽  
Sexual Behavior ◽  
Estrogen Receptor Β ◽  
Male Mice
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