TNF-α antibodies and osteoprotegerin decrease systemic bone loss associated with inflammation through distinct mechanisms in collagen-induced arthritis

Bone ◽  
2004 ◽  
Vol 35 (5) ◽  
pp. 1200-1207 ◽  
Author(s):  
N. Saidenberg-Kermanac'h ◽  
A. Corrado ◽  
D. Lemeiter ◽  
M.C. deVernejoul ◽  
M.C. Boissier ◽  
...  
Keyword(s):  
Bone Loss ◽  
Collagen Induced Arthritis ◽  
Tnf Α ◽  
Systemic Bone Loss

scholarly journals Adrenomedullin22-52combats inflammation and prevents systemic bone loss in murine collagen-induced arthritis

2012 ◽  
Vol 64 (4) ◽  
pp. 1069-1081 ◽  
Author(s):  
Marie-Dominique Ah Kioon ◽  
Carine Asensio ◽  
Hang-Korng Ea ◽  
Frédéric Velard ◽  
Benjamin Uzan ◽  
...  
Keyword(s):  
Bone Loss ◽  
Collagen Induced Arthritis ◽  
Systemic Bone Loss

scholarly journals Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis

2015 ◽  
Vol 195 (11) ◽  
pp. 5136-5148 ◽  
Author(s):  
M. G. Garimella ◽  
S. Kour ◽  
V. Piprode ◽  
M. Mittal ◽  
A. Kumar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Loss ◽  
Collagen Induced Arthritis ◽  
Systemic Bone Loss

scholarly journals Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice

2013 ◽  
Vol 74 (1) ◽  
pp. 220-226 ◽  
Author(s):  
Emmanuel Coste ◽  
Iain R Greig ◽  
Patrick Mollat ◽  
Lorraine Rose ◽  
Mohini Gray ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Loss ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Joint Destruction ◽  
Luciferase Reporter ◽  
Collagen Induced Arthritis ◽  
Arthritis Model ◽  
Anti Inflammatory ◽  
Systemic Bone Loss

IntroductionInflammatory joint diseases such as rheumatoid arthritis are associated with local bone erosions and systemic bone loss, mediated by increased osteoclastic activity. The receptor activator of nuclear factor (NF) κB ligand (RANKL) plays a key role in mediating inflammation-induced bone loss, whereas tumour necrosis factor (TNF) plays a central role in the inflammatory process. Here we tested whether a recently identified class of small molecule inhibitors of RANKL signalling (ABD compounds) also affect TNF signalling and whether these compounds inhibit inflammation in an animal model of rheumatoid arthritis.MethodsThe inhibitory effects of the ABD compounds on TNF-induced signalling were tested in mouse macrophage cultures by western blotting and in an NFκB luciferase-reporter cell line. The anti-inflammatory effects of the compounds were tested in the mouse collagen-induced arthritis model of rheumatoid arthritis.ResultsThe ABD compounds ABD328 and ABD345 both inhibited TNF-induced activation of the NFκB pathway and the extracellular signal-regulated kinase (ERK) and Jun kinase (JNK) mitogen activated protein kinases (MAPKs). When tested in the mouse collagen-induced arthritis model of rheumatoid arthritis, the compounds suppressed inflammatory arthritis, inhibited joint destruction and prevented systemic bone loss. Furthermore, one of the compounds (ABD328) showed oral activity.ConclusionsHere we describe a novel class of small molecule compounds that inhibit both RANKL- and TNF-induced NFκB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in a mouse model of rheumatoid arthritis. These novel compounds therefore represent a promising new class of treatments for inflammatory diseases, such as rheumatoid arthritis.

Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model

2021 ◽  
Author(s):  
Frideriki Poutoglidou ◽  
Chryssa Pourzitaki ◽  
Maria Eleni Manthou ◽  
Efthimios Samoladas ◽  
Athanasios Saitis ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Collagen Induced Arthritis ◽  
Systemic Bone Loss

scholarly journals CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiang Li ◽  
Xiaonan Tang ◽  
Yufei Wang ◽  
Changwei Chai ◽  
Zhehui Zhao ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Erosion ◽  
Osteoclast Differentiation ◽  
Synovial Inflammation ◽  
Systemic Autoimmune Disease ◽  
Dependent Manner ◽  
Collagen Induced Arthritis ◽  
Positive Effects ◽  
Tnf Α ◽  
Cartilage Erosion

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects 1% of the population. CS-semi5 is a semisynthetic chondroitin sulfate. In this study, CS-semi5 was shown to have positive effects on a model of collagen-induced arthritis (CIA). CS-semi5 treatment had obvious effects on weight loss and paw swelling in CIA mice. Post-treatment analysis revealed that CS-semi5 alleviated three main pathologies (i.e., synovial inflammation, cartilage erosion and bone loss) in a dose-dependent manner. Further study showed that CS-semi5 could effectively reduce TNF‐α and IL‐1β production in activated macrophages via the NF‐κB pathway. CS-semi5 also blocked RANKL-trigged osteoclast differentiation from macrophages. Therefore, CS-semi5 may effectively ameliorate synovial inflammation, cartilage erosion and bone loss in RA through NF-κB deactivation.

Persistent Abnormal Immunocytes Induced Systemic Bone Loss in Locally Irradiated Rats

2021 ◽  
Author(s):  
Wei Hong ◽  
Lichen Tang ◽  
Rui Ge ◽  
Weiping Li ◽  
Xiaoyong Shen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Systemic Bone Loss
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