scholarly journals Adrenomedullin22-52combats inflammation and prevents systemic bone loss in murine collagen-induced arthritis

2012 ◽  
Vol 64 (4) ◽  
pp. 1069-1081 ◽  
Author(s):  
Marie-Dominique Ah Kioon ◽  
Carine Asensio ◽  
Hang-Korng Ea ◽  
Frédéric Velard ◽  
Benjamin Uzan ◽  
...  
Keyword(s):  
Bone Loss ◽  
Collagen Induced Arthritis ◽  
Systemic Bone Loss

scholarly journals Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis

2015 ◽  
Vol 195 (11) ◽  
pp. 5136-5148 ◽  
Author(s):  
M. G. Garimella ◽  
S. Kour ◽  
V. Piprode ◽  
M. Mittal ◽  
A. Kumar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Loss ◽  
Collagen Induced Arthritis ◽  
Systemic Bone Loss

scholarly journals Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice

2013 ◽  
Vol 74 (1) ◽  
pp. 220-226 ◽  
Author(s):  
Emmanuel Coste ◽  
Iain R Greig ◽  
Patrick Mollat ◽  
Lorraine Rose ◽  
Mohini Gray ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Loss ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Joint Destruction ◽  
Luciferase Reporter ◽  
Collagen Induced Arthritis ◽  
Arthritis Model ◽  
Anti Inflammatory ◽  
Systemic Bone Loss

IntroductionInflammatory joint diseases such as rheumatoid arthritis are associated with local bone erosions and systemic bone loss, mediated by increased osteoclastic activity. The receptor activator of nuclear factor (NF) κB ligand (RANKL) plays a key role in mediating inflammation-induced bone loss, whereas tumour necrosis factor (TNF) plays a central role in the inflammatory process. Here we tested whether a recently identified class of small molecule inhibitors of RANKL signalling (ABD compounds) also affect TNF signalling and whether these compounds inhibit inflammation in an animal model of rheumatoid arthritis.MethodsThe inhibitory effects of the ABD compounds on TNF-induced signalling were tested in mouse macrophage cultures by western blotting and in an NFκB luciferase-reporter cell line. The anti-inflammatory effects of the compounds were tested in the mouse collagen-induced arthritis model of rheumatoid arthritis.ResultsThe ABD compounds ABD328 and ABD345 both inhibited TNF-induced activation of the NFκB pathway and the extracellular signal-regulated kinase (ERK) and Jun kinase (JNK) mitogen activated protein kinases (MAPKs). When tested in the mouse collagen-induced arthritis model of rheumatoid arthritis, the compounds suppressed inflammatory arthritis, inhibited joint destruction and prevented systemic bone loss. Furthermore, one of the compounds (ABD328) showed oral activity.ConclusionsHere we describe a novel class of small molecule compounds that inhibit both RANKL- and TNF-induced NFκB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in a mouse model of rheumatoid arthritis. These novel compounds therefore represent a promising new class of treatments for inflammatory diseases, such as rheumatoid arthritis.

Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model

2021 ◽  
Author(s):  
Frideriki Poutoglidou ◽  
Chryssa Pourzitaki ◽  
Maria Eleni Manthou ◽  
Efthimios Samoladas ◽  
Athanasios Saitis ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Collagen Induced Arthritis ◽  
Systemic Bone Loss

TNF-α antibodies and osteoprotegerin decrease systemic bone loss associated with inflammation through distinct mechanisms in collagen-induced arthritis

Bone ◽  
2004 ◽  
Vol 35 (5) ◽  
pp. 1200-1207 ◽  
Author(s):  
N. Saidenberg-Kermanac'h ◽  
A. Corrado ◽  
D. Lemeiter ◽  
M.C. deVernejoul ◽  
M.C. Boissier ◽  
...  
Keyword(s):  
Bone Loss ◽  
Collagen Induced Arthritis ◽  
Tnf Α ◽  
Systemic Bone Loss

Persistent Abnormal Immunocytes Induced Systemic Bone Loss in Locally Irradiated Rats

2021 ◽  
Author(s):  
Wei Hong ◽  
Lichen Tang ◽  
Rui Ge ◽  
Weiping Li ◽  
Xiaoyong Shen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Systemic Bone Loss

scholarly journals Serum Bone Biomarkers and Oral/Systemic Bone Loss in Humans

2011 ◽  
Vol 90 (6) ◽  
pp. 747-751 ◽  
Author(s):  
J.B. Payne ◽  
J.A. Stoner ◽  
H.-M. Lee ◽  
P.V. Nummikoski ◽  
R.A. Reinhardt ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Biomarkers ◽  
Systemic Bone Loss

scholarly journals SH3BP2 Gain-Of-Function Mutation Exacerbates Inflammation and Bone Loss in a Murine Collagen-Induced Arthritis Model

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e105518 ◽  
Author(s):  
Tomoyuki Mukai ◽  
Richard Gallant ◽  
Shu Ishida ◽  
Teruhito Yoshitaka ◽  
Mizuho Kittaka ◽  
...  
Keyword(s):  
Bone Loss ◽  
Collagen Induced Arthritis ◽  
Gain Of Function ◽  
Arthritis Model
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