Abacavir prodrugs: Microwave-assisted synthesis and their evaluation of anti-HIV activities

2006 ◽  
Vol 16 (8) ◽  
pp. 2127-2129 ◽  
Author(s):  
Dharmarajan Sriram ◽  
Perumal Yogeeswari ◽  
Naga Sirisha Myneedu ◽  
Vivek Saraswat
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv

Abacavir Prodrugs: Microwave-Assisted Synthesis and Their Evaluation of anti-HIV Activities.

ChemInform ◽  
2006 ◽  
Vol 37 (29) ◽  
Author(s):  
Dharmarajan Sriram ◽  
Perumal Yogeeswari ◽  
Naga Sirisha Myneedu ◽  
Vivek Saraswat
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv

Microwave-assisted synthesis and anti-HIV activity of new benzenesulfonamides bearing 2,5-disubstituted-1,3,4-oxadiazole moiety

2007 ◽  
Vol 18 (4) ◽  
pp. 425-431 ◽  
Author(s):  
Muhammad Zareef ◽  
Rashid Iqbal ◽  
Najim A. Al-Masoudi ◽  
Javid H. Zaidi ◽  
Muhammad Arfan
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv

New chalcones and thiopyrimidine analogues derived from mefenamic acid: microwave-assisted synthesis, anti-HIV activity and cytotoxicity as antileukemic agents

2017 ◽  
Vol 72 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Hanan A. Al-Hazam ◽  
Zeki A. Al-Shamkani ◽  
Najim A. Al-Masoudi ◽  
Bahjat A. Saeed ◽  
Christophe Pannecouque
Keyword(s):  
Mefenamic Acid ◽  
Leukemia Cells ◽  
Basic Medium ◽  
Microwave Assisted Synthesis ◽  
Schmidt Reaction ◽  
Microwave Assisted ◽  
Amide Derivatives ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Hiv 1

AbstractThe development of new HIV non-nucleoside reverse transcriptase inhibitors offers the possibility of generating structures of increased potency. To this end, coupling of mefenamic acid (4) with 4-amino-acetophenone (6) in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine (DMAP) reagents afforded 4-(acetyphenyl)-2-((2,3-dimethylphenyl)amino)benzamide (7). Analogously, treatment of mefenamyl chloride (5) prepared from 4 with 6 under microwave irradiation (MWI) afforded 7. A new series of substituted chalconyl-incorporated amide derivatives of mefenamic acid 8–13 were synthesized from condensation of 7 with various substituted benzaldehydes via the Claisen–Schmidt reaction. Treatment of 8 and 11 with thiourea in a basic medium afforded the thiopyrimidine analogues 14 and 15, respectively. The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compounds 9 and 11 showed cytotoxicity values of 2.17 and 2.06 μm, respectively, against mock-infected MT-4 cells (C type adult T leukemia cells), which considered to be promising antileukemic agents.

Microwave-assisted synthesis, molecular docking and anti-HIV activities of some drug-like quinolone derivatives

2020 ◽  
Vol 29 (6) ◽  
pp. 1067-1076 ◽  
Author(s):  
Ahmed M. Jassem ◽  
Adil M. Dhumad ◽  
Faeza A. Almashal ◽  
Jasim M. Alshawi
Keyword(s):  
Molecular Docking ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv ◽  
Quinolone Derivatives

Parallel Solution-Phase and Microwave-Assisted Synthesis of NewS-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity

2005 ◽  
Vol 48 (25) ◽  
pp. 8000-8008 ◽  
Author(s):  
Fabrizio Manetti ◽  
José A. Esté ◽  
Imma Clotet-Codina ◽  
Mercedes Armand-Ugón ◽  
Giovanni Maga ◽  
...  
Keyword(s):  
Solution Phase ◽  
Microwave Assisted Synthesis ◽  
Parallel Solution ◽  
Microwave Assisted ◽  
Anti Hiv ◽  
Hiv 1

Microwave-Assisted Synthesis and Anti-HIV Activity of New AcyclicC-Nucleosides of 3-(D-Ribo-Tetritol-1-yl)-5-Mercapto-1,2,4-Triazoles. Part 1

2008 ◽  
Vol 27 (5) ◽  
pp. 469-483 ◽  
Author(s):  
Yaseen A. Al-Soud ◽  
Najim A. Al-Masoudi ◽  
Thilo Schuppler ◽  
Erik De Clercq ◽  
Christophe Pannecouque
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv

Microwave-Assisted Synthesis and anti-HIV Activity of New Benzenesulfonamides Bearing 2,5-Disubstituted-1,3,4-oxadiazole Moiety.

ChemInform ◽  
2007 ◽  
Vol 38 (36) ◽  
Author(s):  
Muhammad Zareef ◽  
Rashid Iqbal ◽  
Najim A. Al-Masoudi ◽  
Javid H. Zaidi ◽  
Muhammad Arfan
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv

scholarly journals Microwave Assisted Synthesis and Anti-HIV-RT Activity of Diaryl Benzo[1,3]thiazin-4-ones

2015 ◽  
Vol 35 (6) ◽  
pp. 1370 ◽  
Author(s):  
Junna Feng ◽  
Xiaohui Li ◽  
Jie Shao ◽  
Mo Zhu ◽  
Yan Li ◽  
...  
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Hiv Rt ◽  
Anti Hiv

ChemInform Abstract: Microwave-Assisted Synthesis and anti-HIV Activity of New Acyclic C-Nucleosides of 3-(D-ribo-Tetritol-1-yl)-5-mercapto-1,2,4-triazoles. Part 1.

ChemInform ◽  
2008 ◽  
Vol 39 (43) ◽  
Author(s):  
Yaseen A. Al-Soud ◽  
Najim A. Al-Masoudi ◽  
Thilo Schuppler ◽  
Erik De Clercq ◽  
Christophe Pannecouque
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Anti Hiv
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