Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

2011 ◽  
Vol 19 (24) ◽  
pp. 7526-7533 ◽  
Author(s):  
María Isabel García-Aranda ◽  
Yasmina Mirassou ◽  
Benoit Gautier ◽  
Mercedes Martín-Martínez ◽  
Nicolas Inguimbert ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Cyclic Peptide ◽  
Biological Evaluation ◽  
Peptide Analogues

Ribose-Modified Nucleosides as Ligands for Adenosine Receptors:  Synthesis, Conformational Analysis, and Biological Evaluation of 1‘-C-Methyl Adenosine Analogues

2002 ◽  
Vol 45 (6) ◽  
pp. 1196-1202 ◽  
Author(s):  
Loredana Cappellacci ◽  
Grazia Barboni ◽  
Micaela Palmieri ◽  
Michela Pasqualini ◽  
Mario Grifantini ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Adenosine Receptors ◽  
Biological Evaluation ◽  
Modified Nucleosides ◽  
Adenosine Analogues

scholarly journals Design of Linear and Cyclic Mutant Analogues of Dirucotide Peptide (MBP82–98) against Multiple Sclerosis: Conformational and Binding Studies to MHC Class II

2018 ◽  
Vol 8 (12) ◽  
pp. 213 ◽  
Author(s):  
George Deraos ◽  
Eftichia Kritsi ◽  
Minos-Timotheos Matsoukas ◽  
Konstantina Christopoulou ◽  
Hubert Kalbacher ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Mhc Class Ii ◽  
Cyclic Peptide ◽  
Human Leukocyte ◽  
Conformational Space ◽  
Peptide Ligand ◽  
Altered Peptide Ligand ◽  
Binding Studies ◽  
Peptide Analogues

Background: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. MS is a T cell-mediated disease characterized by the proliferation, infiltration, and attack of the myelin sheath by immune cells. Previous studies have shown that cyclization provides molecules with strict conformation that could modulate the immune system. Methods: In this study, we synthesized peptide analogues derived from the myelin basic protein (MBP)82–98 encephalitogenic sequence (dirucotide), the linear altered peptide ligand MBP82–98 (Ala91), and their cyclic counterparts. Results: The synthesized peptides were evaluated for their binding to human leukocyte antigen (HLA)-DR2 and HLA-DR4 alleles, with cyclic MBP82–98 being a strong binder with the HLA-DR2 allele and having lower affinity binding to the HLA-DR4 allele. In a further step, conformational analyses were performed using NMR spectroscopy in solution to describe the conformational space occupied by the functional amino acids of both linear and cyclic peptide analogues. This structural data, in combination with crystallographic data, were used to study the molecular basis of their interaction with HLA-DR2 and HLA-DR4 alleles. Conclusion: The cyclic and APL analogues of dirucotide are promising leads that should be further evaluated for their ability to alter T cell responses for therapeutic benefit against MS.

Synthesis, conformational analysis and biological evaluation of the lactam analogue of the cyclodepsipeptide apratoxin A

Tetrahedron ◽  
2016 ◽  
Vol 72 (27-28) ◽  
pp. 3823-3831 ◽  
Author(s):  
Ruwen Yin ◽  
Wei Zhang ◽  
Guoyun Liu ◽  
Ping Wu ◽  
Choiwan Lau ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Biological Evaluation

ChemInform Abstract: Conformational Analysis of the Cyclic Peptide Rhizonin A in Solution and Crystalline State.

ChemInform ◽  
1989 ◽  
Vol 20 (32) ◽  
Author(s):  
M. POTGIETER ◽  
P. S. STEYN ◽  
F. R. VAN HEERDEN ◽  
P. H. VAN ROOYEN ◽  
P. L. WESSELS
Keyword(s):  
Conformational Analysis ◽  
Crystalline State ◽  
Cyclic Peptide

ChemInform Abstract: Design and Biological Evaluation of Non-Peptide Analogues of Omega-Conotoxin MVIIA.

ChemInform ◽  
2010 ◽  
Vol 31 (21) ◽  
pp. no-no
Author(s):  
Stefan Menzler ◽  
Jack A. Bikker ◽  
Nirmala Suman-Chauhan ◽  
David C. Horwell
Keyword(s):  
Biological Evaluation ◽  
Peptide Analogues

A Conformational Study of Two Cyclic Peptide Analogues of ?-MSH

1993 ◽  
Vol 680 (1 The Melanotro) ◽  
pp. 517-519
Author(s):  
GEORGE FORSYTH ◽  
SARAH BRANCH ◽  
STEPHEN MOSS ◽  
LIDIA NOTARIANNI ◽  
DAVID OSGUTHORPE ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Conformational Study ◽  
Peptide Analogues
Sign in / Sign up

Export Citation Format

Share Document