Exploring the ‘RPRL’ Motif of Apelin-13 through Molecular Simulation and Biological Evaluation of Cyclic Peptide Analogues

ChemMedChem ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. 1247-1253 ◽  
Author(s):  
N. J. Maximilian Macaluso ◽  
Robert C. Glen
Keyword(s):  
Molecular Simulation ◽  
Cyclic Peptide ◽  
Biological Evaluation ◽  
Peptide Analogues

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

2011 ◽  
Vol 19 (24) ◽  
pp. 7526-7533 ◽  
Author(s):  
María Isabel García-Aranda ◽  
Yasmina Mirassou ◽  
Benoit Gautier ◽  
Mercedes Martín-Martínez ◽  
Nicolas Inguimbert ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Cyclic Peptide ◽  
Biological Evaluation ◽  
Peptide Analogues

scholarly journals Design of Linear and Cyclic Mutant Analogues of Dirucotide Peptide (MBP82–98) against Multiple Sclerosis: Conformational and Binding Studies to MHC Class II

2018 ◽  
Vol 8 (12) ◽  
pp. 213 ◽  
Author(s):  
George Deraos ◽  
Eftichia Kritsi ◽  
Minos-Timotheos Matsoukas ◽  
Konstantina Christopoulou ◽  
Hubert Kalbacher ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Mhc Class Ii ◽  
Cyclic Peptide ◽  
Human Leukocyte ◽  
Conformational Space ◽  
Peptide Ligand ◽  
Altered Peptide Ligand ◽  
Binding Studies ◽  
Peptide Analogues

Background: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. MS is a T cell-mediated disease characterized by the proliferation, infiltration, and attack of the myelin sheath by immune cells. Previous studies have shown that cyclization provides molecules with strict conformation that could modulate the immune system. Methods: In this study, we synthesized peptide analogues derived from the myelin basic protein (MBP)82–98 encephalitogenic sequence (dirucotide), the linear altered peptide ligand MBP82–98 (Ala91), and their cyclic counterparts. Results: The synthesized peptides were evaluated for their binding to human leukocyte antigen (HLA)-DR2 and HLA-DR4 alleles, with cyclic MBP82–98 being a strong binder with the HLA-DR2 allele and having lower affinity binding to the HLA-DR4 allele. In a further step, conformational analyses were performed using NMR spectroscopy in solution to describe the conformational space occupied by the functional amino acids of both linear and cyclic peptide analogues. This structural data, in combination with crystallographic data, were used to study the molecular basis of their interaction with HLA-DR2 and HLA-DR4 alleles. Conclusion: The cyclic and APL analogues of dirucotide are promising leads that should be further evaluated for their ability to alter T cell responses for therapeutic benefit against MS.

Scaffold-based selective SHP2 inhibitors design using core hopping, molecular docking, biological evaluation and molecular simulation

2020 ◽  
Vol 105 ◽  
pp. 104391
Author(s):  
Wei-Ya Li ◽  
Ying Ma ◽  
Hao-Xin Li ◽  
Xin-Hua Lu ◽  
Shan Du ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Molecular Simulation ◽  
Biological Evaluation

ChemInform Abstract: Design and Biological Evaluation of Non-Peptide Analogues of Omega-Conotoxin MVIIA.

ChemInform ◽  
2010 ◽  
Vol 31 (21) ◽  
pp. no-no
Author(s):  
Stefan Menzler ◽  
Jack A. Bikker ◽  
Nirmala Suman-Chauhan ◽  
David C. Horwell
Keyword(s):  
Biological Evaluation ◽  
Peptide Analogues

A Conformational Study of Two Cyclic Peptide Analogues of ?-MSH

1993 ◽  
Vol 680 (1 The Melanotro) ◽  
pp. 517-519
Author(s):  
GEORGE FORSYTH ◽  
SARAH BRANCH ◽  
STEPHEN MOSS ◽  
LIDIA NOTARIANNI ◽  
DAVID OSGUTHORPE ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Conformational Study ◽  
Peptide Analogues

Synthesis and biological evaluation of boron peptide analogues of Belactosin C as proteasome inhibitors

2009 ◽  
Vol 19 (12) ◽  
pp. 3220-3224 ◽  
Author(s):  
Hiroyuki Nakamura ◽  
Mizuyoshi Watanabe ◽  
Hyun Seung Ban ◽  
Wataru Nabeyama ◽  
Akira Asai
Keyword(s):  
Proteasome Inhibitors ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Peptide Analogues

Design, Synthesis, and Biological Evaluation of New Peptide Analogues as Selective COX-2 Inhibitors

2017 ◽  
Vol 350 (10) ◽  
pp. 1700158 ◽  
Author(s):  
Mohammad A. Ahmaditaba ◽  
Soraya Shahosseini ◽  
Bahram Daraei ◽  
Afshin Zarghi ◽  
Mohammad H. Houshdar Tehrani
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Cox 2 ◽  
Cox 2 Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Peptide Analogues

Metal-catalysed tandem metathesis-hydrogenation reactions for the synthesis of carba analogues of cyclic peptides

2005 ◽  
Vol 83 (6-7) ◽  
pp. 875-881 ◽  
Author(s):  
Amanda N Whelan ◽  
Jomana Elaridi ◽  
Roger J Mulder ◽  
Andrea J Robinson ◽  
W Roy Jackson
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Somatostatin Analogues ◽  
Ring Closing Metathesis ◽  
Hydrogenation Reactions ◽  
Peptide Analogues ◽  
Tandem Metathesis

Dicarba cyclic peptide analogues of the cystine-containing octapeptides octreotide, lanreotide, and vapreotide, all known somatostatin analogues, have been synthesized via an on-resin homogeneous metal-catalysed sequence involving ruthenium-catalysed ring-closing metathesis followed by rhodium-catalysed hydrogenation.Key words: dicarba-analogues of cystine-containing peptides, octreotide, vapreotide, and lanreotide; tandem ring-closing metathesis and hydrogenation.

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