Design, synthesis and inhibition activity of a novel cyclic enediyne amino acid conjugates against MPtpA

2011 ◽  
Vol 19 (10) ◽  
pp. 3274-3279 ◽  
Author(s):  
Koushik Chandra ◽  
Debajyoti Dutta ◽  
Analava Mitra ◽  
Amit K. Das ◽  
Amit Basak
Keyword(s):  
Amino Acid ◽  
Inhibition Activity ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Design, synthesis and stimuli responsive gelation of novel stigmasterol–amino acid conjugates

2011 ◽  
Vol 361 (2) ◽  
pp. 587-593 ◽  
Author(s):  
Hana Svobodová ◽  
Nonappa ◽  
Zdeněk Wimmer ◽  
Erkki Kolehmainen
Keyword(s):  
Amino Acid ◽  
Stimuli Responsive ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Design, Synthesis and Antitumor Activity of Dimeric Bile Acid-Amino Acid Conjugates

2007 ◽  
Vol 4 (6) ◽  
pp. 414-418 ◽  
Author(s):  
Yan Li ◽  
Zhen Zhang ◽  
Yong Ju ◽  
Chang-Qi Zhao
Keyword(s):  
Bile Acid ◽  
Amino Acid ◽  
Antitumor Activity ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

2006 ◽  
Vol 16 (14) ◽  
pp. 3809-3812 ◽  
Author(s):  
Orla K. Mc Carthy ◽  
Alessandro Schipani ◽  
Alex Musso Buendía ◽  
Luis M. Ruiz-Perez ◽  
Marcel Kaiser ◽  
...  
Keyword(s):  
Amino Acid ◽  
Trypanosoma Cruzi ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators

2016 ◽  
Vol 124 ◽  
pp. 435-444 ◽  
Author(s):  
Marco Tutone ◽  
Aurora Chinnici ◽  
Anna Maria Almerico ◽  
Ugo Perricone ◽  
Flavia Maria Sutera ◽  
...  
Keyword(s):  
Amino Acid ◽  
Preliminary Evaluation ◽  
Design Synthesis ◽  
Amino Acid Conjugates

scholarly journals Design, Synthesis, Phloem Mobility, and Bioactivities of a Series of Phenazine-1-Carboxylic Acid-Amino Acid Conjugates

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2139 ◽  
Author(s):  
Linhua Yu ◽  
Di Huang ◽  
Xiang Zhu ◽  
Min Zhang ◽  
Zongli Yao ◽  
...  
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Design Synthesis ◽  
Phloem Sap ◽  
Amino Acid Conjugates ◽  
Highly Active ◽  
Vascular Pathogens ◽  
Phloem Mobility ◽  
Active Parent

Developing fungicides with phloem mobility that can be applied to leaves to control root or vascular pathogens has long been desirable. To achieve this goal, an efficient and economical strategy involves introducing an amino acid into the existing highly active parent pesticide molecule. Hence, 12 L-phenazine-1-carboxylic acid (PCA)-amino acid conjugates 4a–l were designed and synthesized via a simple synthetic route. In vitro bioassays results showed that all synthesized compounds 4a–l exhibited certain fungicidal activities against six tested fungi. Compound 4c exhibited relatively good fungicidal activity against Rhizoctonia solani, and the EC50 value was 0.084 ± 0.006 mmol/L. The phloem mobility experiments revealed that introducing an amino acid to PCA could effectively endow PCA with phloem mobility in R. communis L. Among them, nine conjugates were found in phloem sap, and L-PCA-Valine 4d exhibited the highest phloem mobility. Analysis results from the prediction of the Kleier model indicated that an active carrier-mediated mechanism may be involved in L-PCA-amino acid conjugates—a result that needs to be confirmed and complemented with further tests. The current research provides useful data for modifying non-phloem-mobile fungicidal molecules to phloem-mobile types.

Design, synthesis, and in vitro antiplasmodial activity of 4-aminoquinolines containing modified amino acid conjugates

2016 ◽  
Vol 25 (6) ◽  
pp. 1148-1162 ◽  
Author(s):  
Kondaparla Srinivasarao ◽  
Pooja Agarwal ◽  
Kumkum Srivastava ◽  
W. Haq ◽  
Sunil K. Puri ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antiplasmodial Activity ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies

2020 ◽  
Vol 17 (1) ◽  
pp. 71-84
Author(s):  
Riham M. Bokhtia ◽  
Siva S. Panda ◽  
Adel S. Girgis ◽  
Hitesh H. Honkanadavar ◽  
Tarek S. Ibrahim ◽  
...  
Keyword(s):  
Experimental Data ◽  
Antibacterial Activity ◽  
Amino Acid ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antibacterial Properties ◽  
Computational Studies ◽  
Protecting Group ◽  
Amino Acid Conjugates ◽  
Molecular Modeling Studies

Background: Bacterial infections are considered as one of the major global health threats, so it is very essential to design and develop new antibacterial agents to overcome the drawbacks of existing antibacterial agents. Method: The aim of this work is to synthesize a series of new fluoroquinolone-3-carboxamide amino acid conjugates by molecular hybridization. We utilized benzotriazole chemistry to synthesize the desired hybrid conjugates. Result: All the conjugates were synthesized in good yields, characterized, evaluated for their antibacterial activity. The compounds were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Synthesized conjugates were tested for activity against medically relevant pathogens; Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27856) Staphylococcus aureus (ATCC 25923) and Enterococcus faecalis (ATCC 19433). Conclusion: The observed antibacterial experimental data indicates the selectivity of our synthesized conjugates against E.Coli. The protecting group on amino acids decreases the antibacterial activity. The synthesized conjugates are non-toxic to the normal cell lines. The experimental data were supported by computational studies.

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals Nicotinamide riboside–amino acid conjugates that are stable to purine nucleoside phosphorylase

2020 ◽  
Vol 18 (15) ◽  
pp. 2877-2885
Author(s):  
Faisal Hayat ◽  
Marie E. Migaud
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Purine Nucleoside Phosphorylase ◽  
Amino Acid Ester ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Amino Acid Conjugates ◽  
Nicotinamide Riboside

O5′ amino acid ester conjugates of nicotinamide riboside, generated via a reduced intermediate, are stable to purine nucleoside phosphorylase.

Sign in / Sign up

Export Citation Format

Share Document