Novel naphthalimide–amino acid conjugates with flexible leucine moiety as side chain: Design, synthesis and potential antitumor activity

2009 ◽  
Vol 17 (2) ◽  
pp. 592-599 ◽  
Author(s):  
Aibin Wu ◽  
Yufang Xu ◽  
Xuhong Qian
Keyword(s):  
Amino Acid ◽  
Antitumor Activity ◽  
Side Chain ◽  
Design Synthesis ◽  
Amino Acid Conjugates ◽  
Potential Antitumor

Design, Synthesis and Antitumor Activity of Dimeric Bile Acid-Amino Acid Conjugates

2007 ◽  
Vol 4 (6) ◽  
pp. 414-418 ◽  
Author(s):  
Yan Li ◽  
Zhen Zhang ◽  
Yong Ju ◽  
Chang-Qi Zhao
Keyword(s):  
Bile Acid ◽  
Amino Acid ◽  
Antitumor Activity ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Design, synthesis and stimuli responsive gelation of novel stigmasterol–amino acid conjugates

2011 ◽  
Vol 361 (2) ◽  
pp. 587-593 ◽  
Author(s):  
Hana Svobodová ◽  
Nonappa ◽  
Zdeněk Wimmer ◽  
Erkki Kolehmainen
Keyword(s):  
Amino Acid ◽  
Stimuli Responsive ◽  
Design Synthesis ◽  
Amino Acid Conjugates

scholarly journals Research in vivo the qualities of potential antitumor amino-acid derivatives of glycosides of indolocarbazol

2017 ◽  
Vol 16 (4) ◽  
pp. 85-92 ◽  
Author(s):  
I. S. Golubeva ◽  
N. P. Yavorskaya ◽  
O. V. Goryunova
Keyword(s):  
Amino Acid ◽  
Antitumor Activity ◽  
Optimal Dose ◽  
Amino Acid Derivatives ◽  
Tumor Growth Inhibition ◽  
Active Metabolites ◽  
Derivatives Of ◽  
Potential Antitumor

Background. The addition of active metabolites (in particular, amino acids) to the molecule affects the physicochemical and prodrug properties of derivatives of indolocarbazoles. Using computed chemoinformatics, probability antitumor activity of amino-acid derivatives of glycosides of indolocarbazol (AADGI) is predicted with low probability of their cytotoxic activity in vitro. Based on these data, a study of these compounds in vivo is conducted. Objective: the assessment of AADGI as potential antitumor medications. Materials and methods. Research antitumor activity of AADGI was done using murine tumor models - cervical cancer CC-5. Investigated compounds were injected to mice СВА abdominally 5-times daily with interval of 24 h. Observation of animals were continued till their death. Antitumor effect of compounds was assessed by criteria of tumor growth inhibition and increase in life expectancy of mice comparing to control animals. Results. The optimal dose for these series of compounds was titrated and this dose is 100 mg/kg. Antitumor activity of AADGI was assessed on CC-5. Conclusions. Based on data received we suggest an extended study in vivo of antitumor qualities of selected 5 leader AADGI.

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

2006 ◽  
Vol 16 (14) ◽  
pp. 3809-3812 ◽  
Author(s):  
Orla K. Mc Carthy ◽  
Alessandro Schipani ◽  
Alex Musso Buendía ◽  
Luis M. Ruiz-Perez ◽  
Marcel Kaiser ◽  
...  
Keyword(s):  
Amino Acid ◽  
Trypanosoma Cruzi ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators

2016 ◽  
Vol 124 ◽  
pp. 435-444 ◽  
Author(s):  
Marco Tutone ◽  
Aurora Chinnici ◽  
Anna Maria Almerico ◽  
Ugo Perricone ◽  
Flavia Maria Sutera ◽  
...  
Keyword(s):  
Amino Acid ◽  
Preliminary Evaluation ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Design, synthesis and inhibition activity of a novel cyclic enediyne amino acid conjugates against MPtpA

2011 ◽  
Vol 19 (10) ◽  
pp. 3274-3279 ◽  
Author(s):  
Koushik Chandra ◽  
Debajyoti Dutta ◽  
Analava Mitra ◽  
Amit K. Das ◽  
Amit Basak
Keyword(s):  
Amino Acid ◽  
Inhibition Activity ◽  
Design Synthesis ◽  
Amino Acid Conjugates

Synthesis of compounds with potential antitumor activity: IV. Modification of lupinine and menthol by the taxol amino acid moiety

2007 ◽  
Vol 62 (5) ◽  
pp. 261-263 ◽  
Author(s):  
O. N. Zefirova ◽  
E. V. Nurieva ◽  
V. N. Nuriev ◽  
S. A. Kuznetsov ◽  
D. G. Weiss ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antitumor Activity ◽  
Acid Moiety ◽  
Amino Acid Moiety ◽  
Potential Antitumor
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