scholarly journals Total synthesis of phenanthroindolizidine alkaloids (±)-antofine, (±)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity

2008 ◽  
Vol 16 (11) ◽  
pp. 6233-6241 ◽  
Author(s):  
Chung-Ren Su ◽  
Amooru G. Damu ◽  
Po-Cheng Chiang ◽  
Kenneth F. Bastow ◽  
Susan L. Morris-Natschke ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cytotoxic Activity ◽  
Phenanthroindolizidine Alkaloids

Total synthesis of (−)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity

1997 ◽  
Vol 38 (3) ◽  
pp. 317-320 ◽  
Author(s):  
Raymond J Andersen ◽  
John E Coleman ◽  
Edward Piers ◽  
Debra J Wallace
Keyword(s):  
Total Synthesis ◽  
Cytotoxic Activity

scholarly journals Cytotoxic and Anti-HIV Phenanthroindolizidine Alkaloids from Cryptocarya chinensis†

2012 ◽  
Vol 7 (6) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Tian-Shung Wu ◽  
Chung-Ren Su ◽  
Kuo-Hsiung Lee
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Optical Rotation ◽  
Ethanol Extract ◽  
Cancer Cell Lines ◽  
Spectroscopic Methods ◽  
Bioassay Guided Fractionation ◽  
Phenanthroindolizidine Alkaloids ◽  
Anti Hiv

Bioassay-guided fractionation of the cytotoxic ethanol extract of Cryptocarya chinensis has led to the isolation of 11 compounds, including two phenanthroindolizidine alkaloids [(-)-antofine (1) and dehydroantofine (2)], five pavine alkaloids (3-7), and four proaporphine alkaloids (8-11). The structures of the isolated compounds were determined by means of NMR spectroscopic methods, and supported by HRMS and optical rotation data. Compounds 1 and 2 showed cytotoxic activity against four cancer cell lines, L1210, P388, A549, and HCT-8, with 1 being the most potent against A549 and HCT-8 with EC50 values of 0.002 and 0.001 μg/mL, respectively. In addition, 2 is first reported to exhibit significant anti-HIV activity.

Total Synthesis, Structural Elucidation, and Structure–Cytotoxic Activity Relationship of (−)-Gummiferol

2013 ◽  
Vol 78 (6) ◽  
pp. 2443-2454 ◽  
Author(s):  
Hiroyoshi Takamura ◽  
Hiroko Wada ◽  
Nan Lu ◽  
Osamu Ohno ◽  
Kiyotake Suenaga ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cytotoxic Activity ◽  
Structural Elucidation ◽  
Activity Relationship ◽  
Relationship Of

Stereoselective Total Synthesis of Pinolide and Its C2 Epimer and Evaluation of Their Cytotoxic Activity

Synthesis ◽  
2014 ◽  
Vol 47 (05) ◽  
pp. 653-658 ◽  
Author(s):  
Biswanath Das ◽  
Paramesh Jangili ◽  
C. Kumar ◽  
Y. Poornachandra
Keyword(s):  
Total Synthesis ◽  
Cytotoxic Activity

Iron(III) chloride-based mild synthesis of phenanthrene and its application to total synthesis of phenanthroindolizidine alkaloids

Tetrahedron ◽  
2008 ◽  
Vol 64 (32) ◽  
pp. 7504-7510 ◽  
Author(s):  
Kai-Liang Wang ◽  
Mao-Yun Lü ◽  
Qing-Min Wang ◽  
Run-Qiu Huang
Keyword(s):  
Total Synthesis ◽  
Phenanthroindolizidine Alkaloids

Total synthesis of phenanthroindolizidine alkaloids via asymmetric deprotonation of N-Boc-pyrrolidine

RSC Advances ◽  
2014 ◽  
Vol 4 (29) ◽  
pp. 14979-14984 ◽  
Author(s):  
Meng Deng ◽  
Bo Su ◽  
Hui Zhang ◽  
Yuxiu Liu ◽  
Qingmin Wang
Keyword(s):  
Total Synthesis ◽  
Phenanthroindolizidine Alkaloids ◽  
Carbonyl Addition

A concise synthesis of two typical phenanthroindolizidine alkaloids via an asymmetric deprotonation/diastereoselective carbonyl addition strategy is described.

Total synthesis of wewakazole B

2016 ◽  
Vol 14 (41) ◽  
pp. 9712-9715 ◽  
Author(s):  
Bohua Long ◽  
Jingzhao Zhang ◽  
Xudong Tang ◽  
Zhengzhi Wu
Keyword(s):  
Total Synthesis ◽  
Cytotoxic Activity ◽  
Red Sea

Wewakazole B is a novel cyclodecapeptide with highly potent cytotoxic activity isolated from a sample of M. producens collected from the Red Sea.

Total synthesis and cytotoxic activity of dechlorogreensporones A and D

Tetrahedron ◽  
2018 ◽  
Vol 74 (34) ◽  
pp. 4521-4529 ◽  
Author(s):  
Laksamee Jeanmard ◽  
Panata Iawsipo ◽  
Jiraporn Panprasert ◽  
Vatcharin Rukachaisirikul ◽  
Kwanruthai Tadpetch
Keyword(s):  
Total Synthesis ◽  
Cytotoxic Activity
Sign in / Sign up

Export Citation Format

Share Document