In Vitro Cytotoxic Activity of Phenanthroindolizidine Alkaloids fromCynanchumvincetoxicumandTylophoratanakaeagainst Drug-Sensitive and Multidrug-Resistant Cancer Cells

2002 ◽  
Vol 65 (9) ◽  
pp. 1299-1302 ◽  
Author(s):  
Anne K. Lykkeberg ◽  
Jette Christensen ◽  
Bogdan A. Budnik ◽  
Fumiko Abe ◽  
Jerzy W. Jaroszewski
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Phenanthroindolizidine Alkaloids

scholarly journals Aromatic Selenocyanates as a New Class of Non-Mutagenic Antimicrobial Selenium Compounds with Pronounced Activity against Multidrug Resistant ESKAPE Bacteria

2018 ◽  
Author(s):  
Muhammad Jawad Nasim ◽  
Karolina Witek ◽  
Annamaria Kincses ◽  
Muhammad Sarfraz ◽  
Ewa Żesławska ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Multidrug Resistant ◽  
Synthetic Chemistry ◽  
High Biological Activity ◽  
Selenium Compounds ◽  
X Ray Crystallography ◽  
Organic Selenium ◽  
Interesting Class ◽  
Mrsa Strains

Selenocyanates form an interesting class of organic selenium compounds as they serve as multifunctional agents (being the precursors of seleninic acids and diselenides in synthetic chemistry and as antimicrobial and cytotoxic agent in biology) and, due to their similarity with better known thiocyanates promise high biological activity. Yet whilst selenocyanates are common in synthetic chemistry, they are rarely considered in pharmaceutical design. Arylmethyl selenocyanates (1-13) have been synthesized and an insight into their structural properties using X-ray crystallography has been obtained. The compounds subsequently have been evaluated for their potential antimicrobial, nematicidal and cytotoxic activity. ADMET properties in vitro, using mutagenicity (AMES) and permeability (PAMPA) tests, have been determined. The compounds exhibit pronounced activity against various strains of bacteria (both Gram-positive and Gram-negative) and yeasts. Among them, benzylselenocyanate (1) represents the most active anti-ESKAPE agent, with potent antibacterial activity, especially against multidrug resistant MRSA strains (HEMSA 5). Our results demonstrate that the arylmethyl selenocyantes are not only non-mutagenic but also possess moderate cytotoxic activity against cancer cells.

scholarly journals Current Status, Distribution, and Future Directions of Natural Products against Colorectal Cancer in Indonesia: A Systematic Review

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4984
Author(s):  
Didi Nurhadi Illian ◽  
Ihsanul Hafiz ◽  
Okpri Meila ◽  
Ahmad Rusdan Handoyo Utomo ◽  
Arif Nuryawan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Natural Products ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cell Line ◽  
Current Status ◽  
Vitro Assay ◽  
Colorectal Cancer Cells

In 2020, an estimated 19.3 million new cancer cases and nearly 10 million cancer deaths have occurred worldwide, with colorectal cancer ranking as the third most frequently diagnosed (10.0%). Several attempts have been conducted against cancer, including surgery, radiation, monoclonal antibodies, and chemotherapy. Many people choose natural products as alternatives against cancer. These products will not only help in human life preservation but also work as a source of up-to-date information, leading people away from incorrect information. We discuss the current status, distribution, and future implications of protecting populations with natural products as an alternative against colorectal cancer in Indonesia. Thirty-eight studies were included in this review for data extraction. The distribution of natural products in Indonesia that have potential activity against colorectal cancer cells was predominated by terpenoids, followed by phytosterols, phenolics, alkaloids, and polyisoprenoids. The type of cell line utilized in the cytotoxic activity analysis of natural products was the WiDr cell line, followed by HT-29 cells and HCT-116 cells. This review showed that MTT in vitro assay is a general method used to analyze the cytotoxic activity of a natural product against colorectal cancer cells, followed by other in vitro and in vivo methods. The systematic review provided predictions for several secondary metabolites to be utilized as an alternative treatment against colorectal cancer in Indonesia. It also might be a candidate for a future co-chemotherapy agent in safety, quality, and standardization. In addition, computational methods are being developed to predict the drug-likeness of compounds, thus, drug discovery is already on the road towards electronic research and development.

scholarly journals Composition and in-vitro CytotoxicActivities of the Leaf Essential Oil of Beilschmiedia erythrophloia from Taiwan

2013 ◽  
Vol 8 (1) ◽  
pp. 1934578X1300800
Author(s):  
Yu-Chang Su ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cytotoxic Activities ◽  
Anticancer Activities ◽  
Leaf Essential Oil ◽  
Main Components ◽  
Type Apparatus

This study investigated the chemical composition and in-vitro cytotoxic activities of the essential oil isolated from the leaf of Beilschmiedia erythrophloia. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Fifty-five compounds were identified, representing 100% of the oil. The main components identified were β-caryophyllene (22.6%), α-humulene (21.9%), terpinen-4-ol (5.3%), cis-β-ocimene (5.1%), sabinene (5.0%) and limonene (4.5%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells.

Quinone-Fused Pyrazoles through 1,3-Dipolar Cycloadditions: Synthesis of Tricyclic Scaffolds and in vitro Cytotoxic Activity Evaluation on Glioblastoma Cancer Cells

ChemMedChem ◽  
2018 ◽  
Vol 13 (17) ◽  
pp. 1744-1750 ◽  
Author(s):  
Giulio Bertuzzi ◽  
Simone Crotti ◽  
Pierpaolo Calandro ◽  
Bianca Flavia Bonini ◽  
Ilaria Monaco ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Dipolar Cycloadditions ◽  
Activity Evaluation ◽  
Fused Pyrazoles

Cytotoxic activity of medicinal plants of the Kakamega County (Kenya) against drug-sensitive and multidrug-resistant cancer cells

2018 ◽  
Vol 215 ◽  
pp. 233-240 ◽  
Author(s):  
Dominic O. Ochwang’i ◽  
Charles N. Kimwele ◽  
Jemimah A. Oduma ◽  
Peter K. Gathumbi ◽  
Stephen G. Kiama ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Multidrug Resistant

Gold nanorods–trypsin biocorona: a novel nano composite for in vitro cytotoxic activity towards MCF-7 and A-549 cancer cells

2020 ◽  
Vol 44 (47) ◽  
pp. 20574-20583
Author(s):  
Kandoth Kandy Jesna ◽  
Malaichamy Ilanchelian
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Ammonium Bromide ◽  
Binding Affinities ◽  
Cetyltrimethyl Ammonium Bromide ◽  
Nano Composite ◽  
Cetyltrimethyl Ammonium ◽  
Mcf 7

In the present work, we have synthesized cetyltrimethyl ammonium bromide (CTAB) capped gold nanorods (Au NRs) to evaluate apparent binding affinities for the adsorption of trypsin (TRP).

Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes

MedChemComm ◽  
2014 ◽  
Vol 5 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Peng Du ◽  
Uma M. Viswanathan ◽  
Khairan Khairan ◽  
Tomislav Buric ◽  
Nathaniel E. B. Saidu ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells
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