Structure–activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity

2006 ◽  
Vol 14 (24) ◽  
pp. 8467-8487 ◽  
Author(s):  
Fengtian Xue ◽  
Christopher T. Seto
Keyword(s):  
Biological Activity ◽  
Serine Protease ◽  
Cyclic Ketone ◽  
Design Synthesis ◽  
Structure Activity

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

Design, Synthesis, and Biological Activity ofm-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

2005 ◽  
Vol 48 (20) ◽  
pp. 6229-6235 ◽  
Author(s):  
Kevin X. Chen ◽  
F. George Njoroge ◽  
John Pichardo ◽  
Andrew Prongay ◽  
Nancy Butkiewicz ◽  
...  
Keyword(s):  
Biological Activity ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease ◽  
Design Synthesis

Design, synthesis, biological activity and structure-activity relationship studies of chalcone derivatives as potential anti-Candida agents

2018 ◽  
Vol 71 (8) ◽  
pp. 702-712 ◽  
Author(s):  
Jéssica T. Andrade ◽  
Felipe R. S. Santos ◽  
William G. Lima ◽  
Carla D. F. Sousa ◽  
Lohanna S. F. M. Oliveira ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Chalcone Derivatives ◽  
Structure Activity
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