Chemoenzymatic synthesis of CMP–sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP–sialic acid synthetases

2004 ◽  
Vol 12 (24) ◽  
pp. 6427-6435 ◽  
Author(s):  
Hai Yu ◽  
Hui Yu ◽  
Rebekah Karpel ◽  
Xi Chen
Keyword(s):  
Sialic Acid ◽  
Enzyme System ◽  
Chemoenzymatic Synthesis ◽  
One Pot

A new multi-enzyme system for a one-pot synthesis of sialyl oligosaccharides: Combined use of β-galactosidase and α(26)-sialyltransferase coupled with regeneration in situ of CMP-sialic acid

1993 ◽  
Vol 34 (19) ◽  
pp. 3091-3094 ◽  
Author(s):  
Guido F. Herrmann ◽  
Yoshitaka Ichikawa ◽  
Christian Wandrey ◽  
Federico C.A. Gaeta ◽  
James C. Paulson ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Enzyme System ◽  
One Pot ◽  
One Pot Synthesis ◽  
Combined Use

scholarly journals One-pot multi-enzyme (OPME) chemoenzymatic synthesis of sialyl-Tn-MUC1 and sialyl-T-MUC1 glycopeptides containing natural or non-natural sialic acid

2013 ◽  
Vol 21 (16) ◽  
pp. 4778-4785 ◽  
Author(s):  
Hamed Malekan ◽  
Gabriel Fung ◽  
Vireak Thon ◽  
Zahra Khedri ◽  
Hai Yu ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Chemoenzymatic Synthesis ◽  
One Pot ◽  
Sialyl Tn

scholarly journals Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing 4-O-acetyl sialic acid

2016 ◽  
Vol 14 (36) ◽  
pp. 8586-8597 ◽  
Author(s):  
Hai Yu ◽  
Jie Zeng ◽  
Yanhong Li ◽  
Vireak Thon ◽  
Baojun Shi ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Chemoenzymatic Synthesis ◽  
Milk Oligosaccharides ◽  
One Pot

Chemoenzymatic synthesis: Monotreme milk glycans and other sialosides containing a 4-O-acetyl-sialic acid were synthesized in a gram or preparative scales using a one-pot two-enzyme sialylation system containing bacterial CMP-sialic acid synthetase and sialyltransferase PmST3.

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

scholarly journals A Biocatalytic One-Pot Approach for the Preparation of Lignin Oligomers Using an Oxidase/Peroxidase Cascade Enzyme System

2017 ◽  
Vol 359 (19) ◽  
pp. 3354-3361 ◽  
Author(s):  
Mohamed H. M. Habib ◽  
Peter J. Deuss ◽  
Nikola Lončar ◽  
Milos Trajkovic ◽  
Marco W. Fraaije
Keyword(s):  
Enzyme System ◽  
One Pot
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