Smartphone-based differential pulse amperometry system for real-time monitoring of levodopa with carbon nanotubes and gold nanoparticles modified screen-printing electrodes

2019 ◽  
Vol 129 ◽  
pp. 216-223 ◽  
Author(s):  
Daizong Ji ◽  
Ning Xu ◽  
Zixiang Liu ◽  
Zhouyuanjing Shi ◽  
Sze Shin Low ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Real Time ◽  
Screen Printing ◽  
Differential Pulse ◽  
Real Time Monitoring ◽  
Differential Pulse Amperometry

Simultaneous detection of Dopamine and Serotonin in real complex matrices

2020 ◽  
Vol 16 ◽  
Author(s):  
Florina Truţă ◽  
Mihaela Tertisa ◽  
Cecilia Cristea ◽  
Florin Graur
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Simultaneous Detection ◽  
Multiwall Carbon Nanotubes ◽  
Differential Pulse ◽  
Sensitive Detection ◽  
Complex Matrices ◽  
Simple Method ◽  
Starting Point ◽  
Highly Sensitive Detection

Background: Neurotransmitters are chemical messengers with crucial implication in human body. Perturbations in concentration of neurotransmitters can affect a multitude of mental and physical functions, such as heart rate, sleep, appetite and mood. Thus, the sensitive detection of these compounds is a real need for a new generation of treatments. Method: Two important neurotransmitters namely dopamine and serotonin were investigated in this study for simultaneous detection using differential pulse voltammetry. The optimization of several surface parameters were performed in order to choose the best electrode material for electrochemical oxidation of targets. Screen printed electrodes based on carbon, gold and platinum and modified with different nanomaterials (carbon nanotubes, gold nanoparticles and carbon nanotubes decorated with gold nanoparticles) were tested. Results: Carbon-based electrodes modified with multiwall carbon nanotubes and gold nanoparticles were chosen after the optimization protocol. Linear correlations between the analytic signals obtained and the concentration of dopamine and serotonin respectively were obtained with good sensitivity and the detection limits were 0.3 µM for dopamine and 0.8 µM for serotonin with no significant reciprocal influences. Selectivity studies were also performed, as well as tests in real samples (e.g. human serum, tears and saliva) complex matrices for which acceptable recoveries were obtained. Conclusion: The results obtained within this study can be considered as an important starting point for the development of a fast and simple method for selective and highly sensitive detection of neurotransmitters, with possible applications in the diagnosis of different pathologies and for monitoring the effectiveness of the applied drug treatment.

In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7529-7538 ◽  
Author(s):  
Jing Wang ◽  
Yadian Xie ◽  
Liming Wang ◽  
Jinglong Tang ◽  
Jiayang Li ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Real Time ◽  
Real Time Monitoring ◽  
Monitoring Method ◽  
Optoacoustic Tomography

Multispectral optoacoustic tomography (MSOT) provides a real-time monitoring method to evaluate gold nanoparticles' pharmacokinetics and biodistribution.

scholarly journals Real-time monitoring of heat transfer between gold nanoparticles and tethered bilayer lipid membranes

2020 ◽  
Vol 1862 (9) ◽  
pp. 183334
Author(s):  
Amani Alghalayini ◽  
Lele Jiang ◽  
Xi Gu ◽  
Guan Heng Yeoh ◽  
Charles G. Cranfield ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Gold Nanoparticles ◽  
Real Time ◽  
Lipid Membranes ◽  
Bilayer Lipid Membranes ◽  
Real Time Monitoring ◽  
Bilayer Lipid
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