Chemical constituents of Ligusticum chuanxiong and their anti-inflammation and hepatoprotective activities

2020 ◽  
Vol 101 ◽  
pp. 104016 ◽  
Author(s):  
Xiang Yuan ◽  
Bing Han ◽  
Zi-Ming Feng ◽  
Jian-Shuang Jiang ◽  
Ya-Nan Yang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Ligusticum Chuanxiong ◽  
Anti Inflammation

scholarly journals A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

2019 ◽  
Vol 20 (6) ◽  
pp. 1463 ◽  
Author(s):  
Zhenzhen Guo ◽  
Yanmei Lou ◽  
Muyan Kong ◽  
Qing Luo ◽  
Zhongqiu Liu ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Chemical Constituents ◽  
Herbal Medicines ◽  
Major Type ◽  
Clinical Practices ◽  
Antitumor Activities ◽  
Astragali Radix ◽  
Pharmacological Studies ◽  
Anti Inflammation

Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines. Modern pharmacological studies and clinical practices indicate that AR possesses various biological functions, including potent immunomodulation, antioxidant, anti-inflammation and antitumor activities. To date, more than 200 chemical constituents have been isolated and identified from AR. Among them, isoflavonoids, saponins and polysaccharides are the three main types of beneficial compounds responsible for its pharmacological activities and therapeutic efficacy. After ingestion of AR, the metabolism and biotransformation of the bioactive compounds were extensive in vivo. The isoflavonoids and saponins and their metabolites are the major type of constituents absorbed in plasma. The bioavailability barrier (BB), which is mainly composed of efflux transporters and conjugating enzymes, is expected to have a significant impact on the bioavailability of AR. This review summarizes studies on the phytochemistry, pharmacology and pharmacokinetics on AR. Additionally, the use of AR as a personalized medicine based on the BB is also discussed, which may provide beneficial information to achieve a better and more accurate therapeutic response of AR in clinical practice.

scholarly journals Health Promoting Effects of Ziziphus mauritiana : An Overview

2020 ◽  
Vol 11 (1) ◽  
pp. 1067-1072
Author(s):  
Akassh M ◽  
Fathima T ◽  
Mruthunjaya K
Keyword(s):  
Hair Growth ◽  
Web Of Science ◽  
Indian Subcontinent ◽  
Chemical Constituents ◽  
Ziziphus Mauritiana ◽  
Review Of The Literature ◽  
The Family ◽  
Health Promoting ◽  
Antioxidant Effects ◽  
Anti Inflammation

Natural products are the main source for an alternative system of medicine. Ziziphus mauritiana, commonly known as jujubes, belongs to the family Rhamnaceae and is majorly found in the Indian subcontinent. They are traditionally used to treat chronic bronchitis, insomnia, diabetes, diarrhoea, abscesses, wounds, liver diseases, fever, sleeplessness, constipation, urinary diseases, and abdominal pains. Over the course of many years, various parts of Ziziphus mauritiana has been found to possess hair growth stimulating, anti-platelet aggregating, anti-inflammation, wound-healing, anti-obesity, antibacterial, and antioxidant effects. Various peer-reviewed research articles were collected from SCOPUS, PubMed, Google, Research Gate, and Web of Science databases. A total of 26 papers were selected based on their relevance. Acetyljujuboside B, Mauritine A, and Jujuboside A are some of the numerous chemical constituents present in Ziziphus mauritiana. The present review is an effort to provide a comprehensive review of the literature on the health-promoting effects of Ziziphus mauritiana.

scholarly journals Chemical constituents of Dicentra spectabilis and their anti-inflammation effect

2018 ◽  
Vol 61 (1) ◽  
pp. 39-46 ◽  
Author(s):  
A Hyeon Kim ◽  
Ji Hun Jang ◽  
Kyeong Wan Woo ◽  
Jong Eel Park ◽  
Ki Ho Lee ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Anti Inflammation ◽  
Dicentra Spectabilis

Chemical constituents from the rhizome of Ligusticum chuanxiong Hort. and their Nrf2 inducing activity

2021 ◽  
Author(s):  
KAN ZHANG ◽  
KAI-LI FANG ◽  
TIAN WANG ◽  
LIN-TAO XU ◽  
YU ZHAO ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Ligusticum Chuanxiong

scholarly journals Diversity, Chemical Constituents, and Biological Activities of Endophytic Fungi Isolated From Ligusticum chuanxiong Hort

2021 ◽  
Vol 12 ◽  
Author(s):  
Zizhong Tang ◽  
Yihan Qin ◽  
Wenhui Chen ◽  
Zhiqiao Zhao ◽  
Wenjie Lin ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Endophytic Fungi ◽  
Ethyl Acetate Extract ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Radical Scavenging ◽  
Antibacterial Activities ◽  
Penicillium Oxalicum ◽  
Ligusticum Chuanxiong ◽  
Butanol Extract

The objective of this study was to evaluate the diversity of endophytic fungi of different parts of Ligusticum chuanxiong Hort (CX) and further characterize their biological activities and identify chemical compounds produced by these endophytic fungi. A total of 21 endophytic fungi were isolated and identified from CX. Penicillium oxalicum, Simplicillium sp., and Colletotrichum sp. were identified as promising strains by the color reaction. Comparing different organic extracts of the three strains, it was observed that the ethyl acetate extract of Penicillium oxalicum and Simplicillium sp. and the n-butanol extract of Colletotrichum sp. showed significant antioxidant and antibacterial activities. The ethyl acetate extracts of Penicillium oxalicum had outstanding antioxidant and antibacterial effects, and its radical scavenging rates for ABTS and DPPH were 98.43 ± 0.006% and 90.11 ± 0.032%, respectively. At the same time, their IC50 values were only 0.18 ± 0.02 mg/mL and 0.04 ± 0.003 mg/mL. The ethyl acetate extract of Penicillium oxalicum showed MIC value of only 0.5 mg/mL against Escherichia coli and Staphylococcus aureus. By liquid chromatography-mass spectrometry (LC-MS), we found that Penicillium oxalicum could produce many high-value polyphenols, such as hesperidin (36.06 μmol/g), ferulic acid (1.17 μmol/g), and alternariol (12.64 μmol/g), which can be a potential resource for the pharmaceutical industry. In conclusion, these results increase the diversity of CX endophytic fungi and the antioxidant and antibacterial activities of their secondary metabolites.

scholarly journals Fritillariae Thunbergii Bulbus: Traditional Uses, Phytochemistry, Pharmacodynamics, Pharmacokinetics and Toxicity

2019 ◽  
Vol 20 (7) ◽  
pp. 1667 ◽  
Author(s):  
Hong Li ◽  
Andrew Hung ◽  
Mingdi Li ◽  
Angela Yang
Keyword(s):  
Chemical Constituents ◽  
Blood Rheology ◽  
Chemical Compounds ◽  
Pharmacological Effects ◽  
Historical Records ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Anti Inflammation

Fritillariae Thunbergii Bulbus (FTB) has been widely used as an antitussive herb for thousands of years in China. However, FTB’s traditional uses, chemical compounds and pharmacological activities have not been systematically reviewed. This study aimed to review its traditional uses, phytochemistry, pharmacodynamics, pharmacokinetics and toxicity. We searched the Encyclopedia of Traditional Chinese Medicine to explore the historical records which indicate that it acts to clear heat, resolve phlegm, relieve cough, remove toxicity and disperse abscesses and nodules. We searched 11 databases to identify potential phytochemical or pharmacological studies. Characteristics of its chemical constituents, pharmacological effects, pharmacokinetic and toxicity were descriptively summarized. A total of 9706 studies were identified and 83 of them were included. As a result, 134 chemical constituents were identified, including 26 alkaloids, 29 compounds found in essential oils, 13 diterpenoids, two carbohydrates, two sterols, 18 amino acids, six nucleosides, four nucleobases, four fatty acids, three lignans, and 27 elements. Thirteen pharmacological effects of FTB were identified, including anti-cancer, tracheobronchial relaxation, antitussive, expectorant, anti-muscarinic, anti-inflammation, anti-thyroid, regulation of blood rheology, antiulcer, anti-diarrhea, pain suppression, antioxidation and neuroprotection. These pharmacological activities may be mainly attributed to the alkaloids in FTB. Further phytochemical, pharmacological and network pharmacological studies are recommended.

scholarly journals RED GINGER (Zingiber officinale var. rubrum): ITS CHEMICAL CONSTITUENTS, PHARMACOLOGICAL ACTIVITIES AND SAFETY

2019 ◽  
Vol 8 (1) ◽  
pp. 23-29
Author(s):  
Rini Daud Supu ◽  
Ajeng Diantini ◽  
Jutti Levita
Keyword(s):  
Chemical Constituents ◽  
Zingiber Officinale ◽  
The Other ◽  
Herbal Supplements ◽  
Pharmacological Activities ◽  
Adverse Side Effects ◽  
Beneficial Effects ◽  
Medicinal Properties ◽  
Red Ginger ◽  
Anti Inflammation

Ginger (Zingiber officinale) which belongs to the Zingiberaceae family, was first cultivated in Asia (Indonesia and Malaysia). This plant is one of the most commonly used herbal supplements taken by many patients to treat various conditions. Z.officinale has three varieties based on its size, colors of rhizome and chemical constituents i.e. .Z. officinale var. officinale (big white ginger or giant ginger, badak or gajah), Z. officinale var. amarum (small white ginger, emprit), and Z. officinale var. rubrum (small red ginger, merah or beureum). These three varieties may partly be deferred from their essential oil contents and are used for different purposes. The essential oils contained in Z. officinale var. rubrum are higher than the other types of ginger, which makes stronger in its pungency smell and taste. There are many studies that confirm beneficial effects of red ginger against the symptoms of diseases, i.e. anti-inflammation, antioxidant, antiemetic, antibacterial and antidiabetics. Z.officinale var. rubrum is considered to be a safe herbal medicine with only few and insignificant adverse/side effects. Although the medicinal properties of red ginger have been known, further trials in humans are required to determine the efficacy of red ginger (or one or more of its constituents) and to establish what, if any, adverse effects are observed.

Three new compounds from the rhizome of Ligusticum chuanxiong and their anti-inflammation activities

2020 ◽  
Vol 22 (10) ◽  
pp. 920-926
Author(s):  
Xiang Yuan ◽  
Bin Han ◽  
Zi-Ming Feng ◽  
Jian-Shuang Jiang ◽  
Ya-Nan Yang ◽  
...  
Keyword(s):  
Ligusticum Chuanxiong ◽  
New Compounds ◽  
Anti Inflammation

scholarly journals Composition and Anti-inflammatory Activity of Essential Oil of Jatropha Curcas

2017 ◽  
Vol 12 (3) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Tolulope E. Adeosun ◽  
Isiaka A. Ogunwande ◽  
Opeyemi N. Avoseh ◽  
Ismail P. Raji ◽  
Oladipupo A. Lawal
Keyword(s):  
Gas Chromatography ◽  
Essential Oil ◽  
Jatropha Curcas ◽  
Chemical Constituents ◽  
Significant Inhibition ◽  
Inflammatory Activity ◽  
Gas Chromatography Mass Spectrometry ◽  
Leaf Oil ◽  
Anti Inflammatory ◽  
Anti Inflammation

The chemical constituents and anti-inflammatory activity of the essential oil from the leaf of Jatropha curcas L (Euphorbiaceae) collected from Nigeria are reported. The analysis of the chemical constituents of the essential oil was achieved by using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). All constituents of the essential oil, namely neophytadiene (35.8%), phytol (23.1%), trans-pinane (12.7%), 6,10,14-trimethyl-2-pentadecanone (12.3%) and citronellyl propanoate (11.2%), were present in significant amounts. The anti-inflammatory activity of the leaf oil was determined on Wistar rats using egg-albumin as phlogistic agent; significant inhibition ( P< 0.05) was shown at a dose of 2%, v/v. Percentage inhibition of the anti-inflammation increased steadily to 76.6% in the 4th hour.

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