The role of aquaporin-5 in cancer cell migration: A potential active participant

2016 ◽  
Vol 79 ◽  
pp. 271-276 ◽  
Author(s):  
Helene H. Jensen ◽  
Frédéric H. Login ◽  
Jennifer S. Koffman ◽  
Tae-Hwan Kwon ◽  
Lene N. Nejsum
Keyword(s):  
Cell Migration ◽  
Cancer Cell ◽  
Cancer Cell Migration ◽  
Aquaporin 5 ◽  
Active Participant

scholarly journals A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e75034 ◽  
Author(s):  
Deepak Poudyal ◽  
Xiangli Cui ◽  
Phuong Mai Le ◽  
Anne B. Hofseth ◽  
Anthony Windust ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
American Ginseng ◽  
Colon Cancer Cell ◽  
Cancer Cell Migration

scholarly journals Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid-induced cancer cell migration and adhesion

FEBS Letters ◽  
2014 ◽  
Vol 588 (17) ◽  
pp. 2971-2977 ◽  
Author(s):  
Eun Kyoung Kim ◽  
Jung Min Ha ◽  
Young Whan Kim ◽  
Seo Yeon Jin ◽  
Hong Koo Ha ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cell Migration ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Cell ◽  
Lysophosphatidic Acid ◽  
Cancer Cell Migration ◽  
Inhibitory Role

scholarly journals Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion

2004 ◽  
Vol 10 (24) ◽  
pp. 8743-8750 ◽  
Author(s):  
Shailesh Singh ◽  
Udai P. Singh ◽  
Jonathan K. Stiles ◽  
William E. Grizzle ◽  
James W. Lillard
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Functional Role ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

scholarly journals MEKK5 Interacts with and Negatively Regulates the E3 Ubiquitin Ligase NEDD4 for Mediating Lung Cancer Cell Migration

Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1153
Author(s):  
Aiqin Sun ◽  
Jun Zhu ◽  
Song Xia ◽  
Yanling Li ◽  
Tiantian Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Cancer Cell Migration ◽  
Lung Cancer Cell ◽  
Cancer Migration ◽  
Ubiquitination Assay

Our previous studies have shown that the HECT E3 ubiquitin ligase NEDD4 and kinase MEKK5 both play an essential role in lung cancer migration. A report predicts that MEKK5 may be ubiquitinated by NEDD4; however, interaction of MEKK5 with NEDD4 and ubiquitination of MEKK5 by NEDD4 have not been characterized. In this report, we show that NEDD4 interacts with MEKK5 through a conserved WW3 domain by the co-immunoprecipitation and the GST-pulldown assays. The ubiquitination assay indicates that MEKK5 is not a ubiquitination substrate of NEDD4, but negatively regulates NEDD4-mediated ubiquitination. Furthermore, overexpression of MEKK5 significantly reduced the NEDD4-promoted lung cancer cell migration. Taken together, our studies have defined an inhibitory role of MEKK5 in regulation of NEDD4-mediated ubiquitination.

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