Kinetic study of enantioselective hydrolysis of (R, S)-ketoprofen ethyl ester using immobilized T. laibacchii lipase

2011 ◽  
Vol 54 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Yuan-Yuan Zhang ◽  
Jun-Hong Liu
Keyword(s):  
Kinetic Study ◽  
Ethyl Ester ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Isolation of an esterase-producing Trichosporon brassicae and its catalytic performance in kinetic resolution of ketoprofen

2001 ◽  
Vol 47 (12) ◽  
pp. 1101-1106 ◽  
Author(s):  
Duan Shen ◽  
Jian-He Xu ◽  
Peng-Fei Gong ◽  
Hui-Yuan Wu ◽  
You-Yan Liu
Keyword(s):  
Ethyl Ester ◽  
Sole Carbon Source ◽  
Kinetic Resolution ◽  
Enantiomeric Excess ◽  
Catalytic Performance ◽  
Soil Samples ◽  
Enantioselective Hydrolysis ◽  
Resting Cells ◽  
Enantiomeric Ratio ◽  
Hydrolysis Of

A yeast strain CGMCC 0574, identified as Trichosporon brassicae, was selected from 92 strains for its high (S) selectivity in the hydrolysis of ketoprofen ethyl ester. The effective strains of the microorganisms were isolated from soil samples with the ester as the sole carbon source. The ethyl ester proved to be the best substrate for resolution of ketoprofen among several ketoprofen esters examined. The resting cells of CGMCC 0574 could catalyze the hydrolysis of ketoprofen ethyl ester with an enantiomeric ratio of 44.9, giving (S)-ketoprofen an enantiomeric excess of 91.5% at 42% conversion.Key words: ketoprofen, biocatalytic resolution, enantioselective hydrolysis, microbial esterase, Trichosporon brassicae.

Enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester in dispersed aqueous reaction system induced by chiral cyclodextrin

2004 ◽  
Vol 26 (12) ◽  
pp. 965-969 ◽  
Author(s):  
Sun-Hwa Kim ◽  
Tae-Kwon Kim ◽  
Gab-Sang Shin ◽  
Kwang-Woo Lee ◽  
Hyun-Dong Shin ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Reaction System ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies

2002 ◽  
Vol 10 (7) ◽  
pp. 2171-2175 ◽  
Author(s):  
Zhen-Dan Shi ◽  
Bing-Hui Yang ◽  
Jing-Jing Zhao ◽  
Yu-Lin Wu ◽  
Yong-Yong Ji ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Ethyl Ester ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Enantioselective hydrolysis of naproxen ethyl ester catalyzed by polyclonal antibodies

1997 ◽  
Vol 42 (9) ◽  
pp. 741-744 ◽  
Author(s):  
Yunjin Hu ◽  
Binghui Yang ◽  
He Zhao ◽  
Yulin Wu ◽  
Yongyong Ji ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Polyclonal Antibodies ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Benzyl ethers of methyl α-D-glucopyranoside

1980 ◽  
Vol 45 (7) ◽  
pp. 1959-1963 ◽  
Author(s):  
Dušan Joniak ◽  
Božena Košíková ◽  
Ludmila Kosáková
Keyword(s):  
Kinetic Study ◽  
Spectrophotometric Determination ◽  
Reductive Cleavage ◽  
Ether Bond ◽  
Benzyl Ethers ◽  
Acid Catalyzed ◽  
Model Substances ◽  
Hydrolysis Of

Methyl 4-O-(3-methoxy-4-hydroxybenzyl) and methyl 4-O-(3,5-dimethoxy-4-hydroxybenzyl)-α-D-glucopyranoside and their 6-O-isomers were prepared as model substances for the ether lignin-saccharide bond by reductive cleavage of corresponding 4,6-O-benzylidene derivatives. Kinetic study of acid-catalyzed hydrolysis of the compounds prepared was carried out by spectrophotometric determination of the benzyl alcoholic groups set free, after their reaction with quinonemonochloroimide, and it showed the low stability of the p-hydroxybenzyl ether bond.

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