Enantioselective hydrolysis of naproxen ethyl ester catalyzed by polyclonal antibodies

1997 ◽  
Vol 42 (9) ◽  
pp. 741-744 ◽  
Author(s):  
Yunjin Hu ◽  
Binghui Yang ◽  
He Zhao ◽  
Yulin Wu ◽  
Yongyong Ji ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Polyclonal Antibodies ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Isolation of an esterase-producing Trichosporon brassicae and its catalytic performance in kinetic resolution of ketoprofen

2001 ◽  
Vol 47 (12) ◽  
pp. 1101-1106 ◽  
Author(s):  
Duan Shen ◽  
Jian-He Xu ◽  
Peng-Fei Gong ◽  
Hui-Yuan Wu ◽  
You-Yan Liu
Keyword(s):  
Ethyl Ester ◽  
Sole Carbon Source ◽  
Kinetic Resolution ◽  
Enantiomeric Excess ◽  
Catalytic Performance ◽  
Soil Samples ◽  
Enantioselective Hydrolysis ◽  
Resting Cells ◽  
Enantiomeric Ratio ◽  
Hydrolysis Of

A yeast strain CGMCC 0574, identified as Trichosporon brassicae, was selected from 92 strains for its high (S) selectivity in the hydrolysis of ketoprofen ethyl ester. The effective strains of the microorganisms were isolated from soil samples with the ester as the sole carbon source. The ethyl ester proved to be the best substrate for resolution of ketoprofen among several ketoprofen esters examined. The resting cells of CGMCC 0574 could catalyze the hydrolysis of ketoprofen ethyl ester with an enantiomeric ratio of 44.9, giving (S)-ketoprofen an enantiomeric excess of 91.5% at 42% conversion.Key words: ketoprofen, biocatalytic resolution, enantioselective hydrolysis, microbial esterase, Trichosporon brassicae.

Enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester in dispersed aqueous reaction system induced by chiral cyclodextrin

2004 ◽  
Vol 26 (12) ◽  
pp. 965-969 ◽  
Author(s):  
Sun-Hwa Kim ◽  
Tae-Kwon Kim ◽  
Gab-Sang Shin ◽  
Kwang-Woo Lee ◽  
Hyun-Dong Shin ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Reaction System ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies

2002 ◽  
Vol 10 (7) ◽  
pp. 2171-2175 ◽  
Author(s):  
Zhen-Dan Shi ◽  
Bing-Hui Yang ◽  
Jing-Jing Zhao ◽  
Yu-Lin Wu ◽  
Yong-Yong Ji ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Ethyl Ester ◽  
Enantioselective Hydrolysis ◽  
Hydrolysis Of

Synthesis of Normuramic Acid Carba Analog and Its Glycopeptide Derivative Resistant to β-Elimination Splitting of the Side Chain

2000 ◽  
Vol 65 (11) ◽  
pp. 1726-1736 ◽  
Author(s):  
Miroslav Ledvina ◽  
Radka Pavelová ◽  
Anna Rohlenová ◽  
Jan Ježek ◽  
David Šaman
Keyword(s):  
Ethyl Ester ◽  
Alkaline Hydrolysis ◽  
Benzyl Ester ◽  
Side Chain ◽  
Propanoic Acid ◽  
Hydrolysis Of

Carba analogs of normuramic acid, i.e., 3-(benzyl 2-acetamido-2,3-dideoxy-4,6-O-isopropylidene-α-D-glucopyranosid-3-yl)propanoic acid derivatives (nitrile or esters) 3a-3c were prepared by addition of radicals generated from benzyl 2-acetamido-2-deoxy-4,6-O-isopropylidene-3-O-[(methylsulfanyl)thiocarbonyl]- (2a) or -3-O-(phenoxythiocarbonyl)-α-D-glucopyranoside (2b) with Bu3SnH to acrylonitrile or acryl esters. Alkaline hydrolysis of ethyl ester 3c afforded 3-(benzyl 2-acetamido-2,3-dideoxy-4,6-O-isopropylidene-α-D-glucopyranosid-3-yl)propanoic acid (5). Coupling of acid 5 with L-2-aminobutanoyl-D-isoglutamine benzyl ester trifluoroacetate and subsequent deprotection of the intermediate 6 furnished N-[3-(2-acetamido-2,3-dideoxy-α-D-glucopyranosid-3-yl)propanoyl]-L-2-aminobutanoyl-D-isoglutamine (7).

Sign in / Sign up

Export Citation Format

Share Document