Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins

2012 ◽  
Vol 83 (3) ◽  
pp. 355-367 ◽  
Author(s):  
Anne V. McNamara ◽  
Monica Barclay ◽  
Alastair J.M. Watson ◽  
John R. Jenkins
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Topoisomerase I ◽  
Human Colon ◽  
Cell Cycle Checkpoint ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Checkpoint Proteins ◽  
Cycle Checkpoint ◽  
Human Colon Cancer Cells

Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation

2002 ◽  
Vol 63 (4) ◽  
pp. 607-613 ◽  
Author(s):  
Jeffrey Cummings ◽  
Gary Boyd ◽  
Brian T. Ethell ◽  
Janet S. Macpherson ◽  
Brian Burchell ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Topoisomerase I ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Topoisomerase I Inhibitors ◽  
Human Colon Cancer Cells

Brosimone I, an isoprenoid-substituted flavonoid, induces cell cycle G1phase arrest and apoptosis through ROS-dependent endoplasmic reticulum stress in HCT116 human colon cancer cells

2019 ◽  
Vol 10 (5) ◽  
pp. 2729-2738 ◽  
Author(s):  
Yueliang Zhao ◽  
Yue Zhou ◽  
Mingfu Wang
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Endoplasmic Reticulum ◽  
Cell Growth ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Cell Growth Inhibition ◽  
Human Colon Cancer ◽  
Artocarpus Heterophyllus ◽  
Human Colon Cancer Cells

Brosimone I, an isoprenoid-substituted flavonoid fromArtocarpus heterophyllus, induces cell growth inhibition through the induction of ROS-mediated increased cytosolic Ca2+, ER stress, and the activation of the CaMKK-AMPK pathway.

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