Extraction and partial purification of secondary metabolites from endophytic actinomycetes of marine green algae Caulerpa racemosa against multi drug resistant uropathogens

2019 ◽  
Vol 17 ◽  
pp. 750-757 ◽  
Author(s):  
G. Ramachandran ◽  
G. Rajivgandhi ◽  
M. Maruthupandy ◽  
N. Manoharan
Keyword(s):  
Secondary Metabolites ◽  
Green Algae ◽  
Partial Purification ◽  
Drug Resistant ◽  
Caulerpa Racemosa ◽  
Endophytic Actinomycetes

scholarly journals Partial Purification and Characterization of Albain 1, a Triterpene with Antimicrobial Activity, from the Wood Extract of Avicennia alba Blume

2020 ◽  
pp. 38-48
Author(s):  
Moumita Choudhury ◽  
Kalishankar Mukherjee ◽  
Arnab De ◽  
Amalesh Samanta ◽  
Amit Roy
Keyword(s):  
Antimicrobial Activity ◽  
Secondary Metabolites ◽  
1H Nmr ◽  
Biological Activities ◽  
New Drugs ◽  
Partial Purification ◽  
Molecular Formula ◽  
Pharmaceutical Industries ◽  
Wood Extract ◽  
Avicennia Alba

Secondary metabolites of plants are important resources for development of new drugs. Mangrove plants are very well known sources of wide variety of secondary metabolites. Many of these secondary metabolites from mangroves have been found to possess significant biological activities where human health is concerned. Avicennia alba Blume is one such mangrove plant with reports of having many such secondary metabolites of clinical and commercial interests. Aim: To evaluate antimicrobial activity potential of A. alba wood extract and to isolate new bioactive constituent(s) responsible for such biological activity. Methodology: Preliminary screenings of antimicrobial activities in different organic solvent extracts of A. alba wood tissue were done by TLC-bioautography method and phytochemical nature of the antimicrobial constituent(s) in the extracts have been studied. One compound exhibiting significant antimicrobial activity, named as Albain 1, has been isolated. MIC value has been determined for Albain 1. The purity and structure of Albain 1 have been determined by HPLC, 1H NMR, FTIR and HRMS etc. analysis. Results: 1H NMR, FTIR and HRMS analysis have found out that the isolated compound Albain 1 is a triterpene and the molecular formula is C30H48O4. It has exhibited remarkable antimicrobial activity against Bacillus cereus, Bacillus polymyxa, Bacillus pumilas (MIC 125 μg / ml). Conclusion: The observed antimicrobial activity of the isolated fraction of A. alba offer great potentials in pharmaceutical industries.

scholarly journals Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 385 ◽  
Author(s):  
Holly Siddique ◽  
Barbara Pendry ◽  
M. Mukhlesur Rahman
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Mass Spectra ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Drug Resistant ◽  
Two Dimensional ◽  
Methicillin Resistant ◽  
One Dimensional ◽  
Nmr Data

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (1H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities

2019 ◽  
pp. 207-296 ◽  
Author(s):  
Darlon Irineu Bernardi ◽  
Fernanda Oliveira das Chagas ◽  
Afif Felix Monteiro ◽  
Gabriel Franco dos Santos ◽  
Roberto Gomes de Souza Berlinck
Keyword(s):  
Secondary Metabolites ◽  
Biological Activities ◽  
Endophytic Actinomycetes

Secondary metabolites from green algae Ulva pertusa

2010 ◽  
Vol 46 (5) ◽  
pp. 828-830 ◽  
Author(s):  
Chang-Yun Wang ◽  
Lei Han ◽  
Kai Kang ◽  
Chang-Lun Shao ◽  
Yu-Xi Wei ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Green Algae ◽  
Ulva Pertusa

scholarly journals Biocidal effect of lichen secondary metabolites against rock-dwelling microcolonial fungi, cyanobacteria and green algae

2013 ◽  
Vol 84 ◽  
pp. 300-306 ◽  
Author(s):  
Claudia Gazzano ◽  
Sergio E. Favero-Longo ◽  
Paola Iacomussi ◽  
Rosanna Piervittori
Keyword(s):  
Secondary Metabolites ◽  
Green Algae ◽  
Microcolonial Fungi

scholarly journals Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

Marine Drugs ◽  
2021 ◽  
Vol 19 (10) ◽  
pp. 530
Author(s):  
Ramanathan Srinivasan ◽  
Arunachalam Kannappan ◽  
Chunlei Shi ◽  
Xiangmin Lin
Keyword(s):  
Secondary Metabolites ◽  
Marine Environment ◽  
Antimicrobial Agents ◽  
Drug Resistant ◽  
Antimicrobial Compounds ◽  
Antimicrobial Drugs ◽  
Scientific Investigations ◽  
Microbial Infections ◽  
Resistant Strains ◽  
Untapped Resource

The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is a dire need to identify and develop novel and effective antimicrobial agents to treat infections from antimicrobial-resistant strains. The marine environment is rich in ecological biodiversity and can be regarded as an untapped resource for prospecting novel bioactive compounds. Therefore, exploring the marine environment for antimicrobial agents plays a significant role in drug development and biomedical research. Several earlier scientific investigations have proven that bacterial diversity in the marine environment represents an emerging source of structurally unique and novel antimicrobial agents. There are several reports on marine bacterial secondary metabolites, and many are pharmacologically significant and have enormous promise for developing effective antimicrobial drugs to combat microbial infections in drug-resistant pathogens. In this review, we attempt to summarize published articles from the last twenty-five years (1996–2020) on antimicrobial secondary metabolites from marine bacteria evolved in marine environments, such as marine sediment, water, fauna, and flora.

scholarly journals OPPORTUNITIES AND CHALLENGES FOR DEVELOPING CAULERPA RACEMOSA AS FUNCTIONAL FOODS

2015 ◽  
Vol 2 (1) ◽  
pp. 85
Author(s):  
Diini Fithriani
Keyword(s):  
Secondary Metabolites ◽  
Dietary Fiber ◽  
Functional Food ◽  
Functional Foods ◽  
Public Awareness ◽  
Caulerpa Racemosa ◽  
Active Compounds ◽  
Insoluble Dietary Fiber ◽  
Oxidation Processes ◽  
Green Seaweed

The higher public awareness of the health in community would made the view of some people for food has shifted, not only as relieving hunger, but also can provide a real impact for health. This phenomenon has resulted a term what is called functional food’. Functional food is defined as food which contain active compounds that play a role in increasing endurance, minimize the risk of attack of certain diseases and to provide maximum health benefits. One of marine resource that have a potency to develop as  functional foods is Caulerpa racemosa. Caulerpa racemosa is one of green seaweed that grows naturally in the waters of Indonesia. Caulerpa racemosa found growing on coral substrate or a substrate of sand-rubble. Caulerpa racemosa is edible or can be consumed by humans. Caulerpa racemosa from Indonesia contains high insoluble dietary fiber. Insoluble dietary fiber contains cellulose and hemicellulose, who plays an important role in preventing constipation, colitis and hemmoroid. In other hand Caulerpa racemosa can also produce secondary metabolites, including antioxidants. Antioxidants are substances that are capable of slowing or preventing the oxidation processes that are beneficial to health.Keywords: antioxidant, Caulerpa racemosa, fiber, functional food, health

Dibenzofurans from lichens – a pharmacological overview

2021 ◽  
Vol 21 ◽  
Author(s):  
Isabel Ureña-Vacas ◽  
Elena González-Burgos ◽  
Divakar Pradeep Kumar ◽  
M. Pilar Gómez-Serranillos
Keyword(s):  
Secondary Metabolites ◽  
Small Group ◽  
Green Algae ◽  
Pharmacological Activity ◽  
Usnic Acid ◽  
Cytotoxic Activities ◽  
Symbiotic Association

: Lichens are a symbiotic association between a fungus (mycobiont) and a green algae/cyanobacterium (photobiont). Lichens are a source of secondary metabolites, most of them being exclusively for these species, among which dibenzofurans are found. Dibenzofurans are a small group (over 35 different identified compounds), being usnic acid the most studied. In the last 10 years, there has been a growing interest in the pharmacological activity of dibenzofurans. In this work, dibenzofurans isolated from lichens (alectosarmentin, condidymic acid, didymic acid, isousnic acid, isostrepsilic acid, usimines A-C and usnic acid) were reviewed, most of which showed antibacterial, antifungal, and cytotoxic activities. These findings provide future guidance for research on pharmacological activity of dibenzofurans.

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