Statistical optimization for the improved production of an extracellular alkaline nuclease by halotolerant Allobacillus halotolerans MSP69: Scale-up approach and its potential as flavor enhancer of fish sauce

Biocatalysis and Agricultural Biotechnology ◽

10.1016/j.bcab.2016.09.011 ◽

2016 ◽

Vol 8 ◽

pp. 236-247

Author(s):

Julalak Chuprom ◽

Preeyanuch Bovornreungroj ◽

Mehraj Ahmad ◽

Duangporn Kantachote ◽

Toshiki Enomoto

Keyword(s):

Scale Up ◽

Statistical Optimization ◽

Fish Sauce ◽

Alkaline Nuclease ◽

Flavor Enhancer

Download Full-text

Statistical optimization of process variables for the production of an anticancer drug (colchicine derivatives) through fermentation: at scale-up level

New Biotechnology ◽

10.1016/j.nbt.2010.07.008 ◽

2011 ◽

Vol 28 (1) ◽

pp. 79-85 ◽

Cited By ~ 14

Author(s):

Kashyap Kumar Dubey ◽

B.K. Behera

Keyword(s):

Anticancer Drug ◽

Scale Up ◽

Statistical Optimization ◽

Process Variables ◽

Colchicine Derivatives

Download Full-text

Statistical optimization of conditions for protease production fromBacillus sp. and its scale-up in a bioreactor

Applied Biochemistry and Biotechnology ◽

10.1007/bf02729064 ◽

2007 ◽

Vol 141 (2-3) ◽

pp. 229-239 ◽

Cited By ~ 14

Author(s):

Saurabh Saran ◽

Jasmine Isar ◽

Rajendra Kumar Saxena

Keyword(s):

Scale Up ◽

Statistical Optimization ◽

Protease Production

Download Full-text

Sea Almond as a Promising Feedstock for Green Diesel: Statistical Optimization and Power Rate Law Based Chemical Kinetics of Its Consecutive Irreversible Methanolysis

Prunus ◽

10.5772/intechopen.93880 ◽

2020 ◽

Author(s):

Chizoo Esonye ◽

Okechukwu Donminic Onukwuli ◽

Akuzuo Uwaoma Ofoefule ◽

Cyril Sunday Ume ◽

Nkiruka Jacintha Ogbodo

Keyword(s):

Kinetic Model ◽

Chemical Kinetics ◽

Seed Oil ◽

Scale Up ◽

Statistical Optimization ◽

Industrial Scale ◽

Order Kinetic ◽

Rate Law ◽

Power Rate ◽

Order Kinetic Model

For successful industrial scale-up and effective cost analysis of transesterification process, presentation of complimentary research data from process optimization using statistical design techniques, chemical kinetics and thermodynamics are essential. Full factorial central composite design (FFCCD) was applied for the statistical optimization of base methanolysis of sea almond (Terminalia catappa) seed oil using response surface methodology (RSM) coupled with desirability function analysis on quadratic model. Reaction time had the most significant impact on the biodiesel yield. Optimum conditions for biodiesel yield of 93.09 wt% validated at 92.58 wt% were 50.03°C, 2.04 wt% catalyst concentration, 58.5 min and 4.66 methanol/oil molar ratio with overall desirability of 1.00. Ascertained fuel properties of the FAME were in compliance with international limits. GC–MS, FTIR and NMR characterizations confirmed unsaturation and good cold-flow qualities of the biodiesel. Based on power rate law, second-order kinetic model out-performed first-order kinetic model. Rate constants of the triglyceride (TG), diglycerides (DG) and monoglycerides (MG) hydrolysis were in the range of 0.00838–0.0409 wt%/min while activation energies were 12.76, 15.83 and 22.43 kcal/mol respectively. TG hydrolysis to DG was the rate determining step. The optimal conditions have minimal error and would serve as a springboard for industrial scale-up of biodiesel production from T. catappa seed oil.

Download Full-text

Shikimic acid, a base compound for the formulation of swine/avian flu drug: statistical optimization, fed-batch and scale up studies along with its application as an antibacterial agent

Antonie van Leeuwenhoek ◽

10.1007/s10482-014-0340-z ◽

2014 ◽

Vol 107 (2) ◽

pp. 419-431 ◽

Cited By ~ 9

Author(s):

P. Tripathi ◽

G. Rawat ◽

S. Yadav ◽

R. K. Saxena

Keyword(s):

Antibacterial Agent ◽

Shikimic Acid ◽

Scale Up ◽

Statistical Optimization ◽

Fed Batch ◽

Avian Flu ◽

Base Compound

Download Full-text

NiAl precipitation in Fe-12w/o Cr-5w/o Ni-4w/o Al

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010007480x ◽

1983 ◽

Vol 41 ◽

pp. 202-203

Author(s):

L.E. Murr ◽

J.S. Dunning ◽

S. Shankar

Keyword(s):

Solid Solution ◽

Stainless Steel ◽

Stainless Steels ◽

Alloy Composition ◽

Chromium Content ◽

Scale Up ◽

Optical Metallography ◽

Property Evaluation ◽

310 Stainless Steel ◽

Microstructural Studies

Aluminum additions to conventional 18Cr-8Ni austenitic stainless steel compositions impart excellent resistance to high sulfur environments. However, problems are typically encountered with aluminum additions above about 1% due to embrittlement caused by aluminum in solid solution and the precipitation of NiAl. Consequently, little use has been made of aluminum alloy additions to stainless steels for use in sulfur or H2S environments in the chemical industry, energy conversion or generation, and mineral processing, for example.A research program at the Albany Research Center has concentrated on the development of a wrought alloy composition with as low a chromium content as possible, with the idea of developing a low-chromium substitute for 310 stainless steel (25Cr-20Ni) which is often used in high-sulfur environments. On the basis of workability and microstructural studies involving optical metallography on 100g button ingots soaked at 700°C and air-cooled, a low-alloy composition Fe-12Cr-5Ni-4Al (in wt %) was selected for scale up and property evaluation.

Download Full-text