scholarly journals A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKAy mice

2018 ◽  
Vol 498 (3) ◽  
pp. 633-639 ◽  
Author(s):  
Peng Liu ◽  
Tingting Feng ◽  
Xuan Zuo ◽  
Xiao Wang ◽  
Jinque Luo ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Kkay Mice ◽  
Type 2 Diabetic ◽  
Sirt1 Activator

Changes in insulin sensitivity and DHEAS in type 2 diabetic men treated with liraglutide

2014 ◽  
Author(s):  
Gonzalo Piedrola ◽  
Daniel Cepero ◽  
Concepcion Gil ◽  
Jessica Ramirez ◽  
Ricardo Roa
Keyword(s):  
Insulin Sensitivity ◽  
Type 2 Diabetic

Long-Term Oral L-Arginine Administration Improves Peripheral and Hepatic Insulin Sensitivity in Type 2 Diabetic Patients

Diabetes Care ◽  
2001 ◽  
Vol 24 (5) ◽  
pp. 875-880 ◽  
Author(s):  
P. Piatti ◽  
L. D. Monti ◽  
G. Valsecchi ◽  
F. Magni ◽  
E. Setola ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hepatic Insulin Sensitivity ◽  
Type 2 Diabetic

scholarly journals Consumption of Whole Eggs Promotes Insulin Sensitivity in Db/db Mice (OR34-01-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Peiran Lu ◽  
Lei Wu ◽  
Xin Guo ◽  
Siau Yen Wong ◽  
Stephen Clarke ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Cholesterol Synthesis ◽  
Respiratory Activity ◽  
High Cholesterol ◽  
Egg Consumption ◽  
Type 2 Diabetic ◽  
Mitochondrial Respiratory Activity

Abstract Objectives Chicken eggs have a high nutrient density. Some country guidelines recommend that people with type 2 diabetes (T2D) limit their consumption of eggs due to its high cholesterol content. However, several clinical studies showed that egg intake is associated with a lower risk of type 2 diabetes. In the current study, we sought to explore whether egg consumption improves insulin sensitivity and subsequent blood glucose management in type 2 diabetic db/db mice. Methods Six-week-old male db/db mice were fed a low-fat diet (LFD, 10 kCal % from fat) or LFD supplemented with 1% whole eggs (Egg) for 8 weeks. At the termination of the study, mice were fasted for 3 hrs prior to euthanization. Blood and other tissues were collected for laboratory assessments. Plasma metabolic parameters and pro-inflammatory cytokines were monitored by a clinical analyzer and ELISA, respectively. Hepatic and skeletal muscle mitochondrial respiratory activity was assessed by a Seahorse XFe Analyzer. Hepatic gene expression was analyzed by transcriptomics and confirmed by real-time PCR and/or Western blot. Results Egg consumption significantly increased body weight gain, lowered fasting blood glucose, insulin, and IL-6 levels, and elevated total cholesterol, HDL, LDL, and GLP-1 levels. Only the basal mitochondrial respiratory activity was decreased, and the complex II respiratory activity was increased in gastrocnemius muscles in mice fed Egg. Hepatic mitochondrial activity was not altered by diet. Mechanistically, transcriptomics results revealed that hepatic genes involved in enhanced insulin sensitivity were highly expressed, but genes in endogenous cholesterol synthesis were significantly suppressed after egg consumption. Conclusions The results suggest that egg consumption is beneficial to blood glucose control in type 2 diabetic mice. Type 2 diabetic animal could manage the cholesterol level through suppression of de novo cholesterol synthesis when consuming a high cholesterol diet, e.g., egg diet. Funding Sources National egg nutrition center grant USDA NIFA grant

Beneficial effect of galanin on insulin sensitivity in muscle of type 2 diabetic rats

2011 ◽  
Vol 103 (3-4) ◽  
pp. 284-289 ◽  
Author(s):  
Biao He ◽  
Mingyi Shi ◽  
Ling Zhang ◽  
Guangzhi Li ◽  
Lingxiang Zhang ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Beneficial Effect ◽  
Diabetic Rats ◽  
Type 2 Diabetic
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