Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma

2016 ◽  
Vol 473 (4) ◽  
pp. 913-919 ◽  
Author(s):  
Xudong Li ◽  
Yan Lin ◽  
Xi Yang ◽  
Xiaoguang Wu ◽  
Xiaoguang He
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cell Invasion ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ezh2 Expression

Long Noncoding RNA SPRY4-IT1 Modulates Ketamine-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons through EZH2

2021 ◽  
pp. 1-9
Author(s):  
Jingyuan Huang ◽  
Yan Xu ◽  
Fang Wang ◽  
Haili Wang ◽  
Lu Li ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Embryonic Stem ◽  
Protective Effects ◽  
Tyrosine Kinase Signaling ◽  
Ezh2 Expression ◽  
Induced Neurons ◽  
Neurite Degeneration ◽  
Dose Dependent

<b><i>Objective:</i></b> This study aimed to investigate whether long noncoding RNA sprouty receptor tyrosine kinase signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is involved in the regulation of ketamine-induced neurotoxicity. <b><i>Methods:</i></b> Human embryonic stem cells (hESCs) were induced into neurons in vitro and treated with ketamine. Apoptosis and neurite degeneration assays were used to determine ketamine-induced neurotoxicity and qRT-PCR to determine SPRY4-IT1 expression. SPRY4-IT1 was downregulated in hESC-induced neurons to examine its regulation on ketamine-induced neurotoxicity. The correlation between enhancer of zeste homolog 2 (EZH2) and SPRY4-IT1 was also examined. EZH2 was upregulated in SPRY4-IT1-downregualted hESC-induced neurons to further examine its participation in SPRY4-IT1-mediated ketamine neurotoxicity. <b><i>Results:</i></b> Ketamine-induced dose-dependent apoptosis, neurite degeneration, and SPRY4-IT1 upregulation in hESC-induced neurons. Lentivirus-mediated SPRY4-IT1 downregulation protected ketamine neurotoxicity. EZH2 expression was positively correlated with SPRY4-IT1 in hESC-induced neurons. EZH2 overexpression markedly reversed the protective effects of SPRY4-IT1 knockdown on ketamine neurotoxicity. <b><i>Conclusions:</i></b> SPRY4-IT1 is involved in anesthesia-induced neurotoxicity, possibly through the regulation on EZH2 gene.

scholarly journals Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145

2018 ◽  
Vol Volume 11 ◽  
pp. 7483-7492 ◽  
Author(s):  
Jing Wu ◽  
Mingyu Du ◽  
Qian Zhang ◽  
Wenjun Zhang ◽  
Yanxin Fan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Carcinoma Cells ◽  
Invasion And Migration ◽  
And Migration

scholarly journals Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma

2020 ◽  
Vol 190 (12) ◽  
pp. 2343-2354
Author(s):  
Qiang Li ◽  
Yiming Jiang ◽  
Guansheng Zhong ◽  
Yanwei Lu ◽  
Tao Song ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Nasopharyngeal Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Long noncoding RNA SMAD5‐AS1 acts as a microRNA‐106a‐5p sponge to promote epithelial mesenchymal transition in nasopharyngeal carcinoma

2019 ◽  
Vol 33 (11) ◽  
pp. 12915-12928 ◽  
Author(s):  
Ying‐Juan Zheng ◽  
Jing‐Yi Zhao ◽  
Tian‐Song Liang ◽  
Ping Wang ◽  
Juan Wang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition
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