Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates caspases in human prostate cancer cells through sigma 1 receptor

2016 ◽  
Vol 470 (2) ◽  
pp. 319-323 ◽  
Author(s):  
Dibash Das ◽  
Leah Persaud ◽  
Jordan Dejoie ◽  
Mireille Happy ◽  
Oliver Brannigan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Tumor Necrosis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Sigma 1 Receptor ◽  
Sigma 1 ◽  
Necrosis Factor

scholarly journals Tunicamycin Enhances Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Human Prostate Cancer Cells

2005 ◽  
Vol 65 (14) ◽  
pp. 6364-6370 ◽  
Author(s):  
Takumi Shiraishi ◽  
Tatsushi Yoshida ◽  
Susumu Nakata ◽  
Mano Horinaka ◽  
Miki Wakada ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Tumor Necrosis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Necrosis Factor

Interleukin-6, Tumor Necrosis Factor-α Expression Levels in Prostate Cancer Tissues and Their Effects on Epithelial Interstitial Transformation, Migration and Invasion in Prostate Cancer Cells

2020 ◽  
Vol 10 (12) ◽  
pp. 1773-1779
Author(s):  
Desheng Li ◽  
Shanbin Zhang ◽  
Minfang Zuo ◽  
Xinming Hu ◽  
Shuming He
Keyword(s):  
Prostate Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Prostate Cancer Cells ◽  
Mesenchymal Transition ◽  
Necrosis Factor

Background: To investigate the expression of Interleukin-6, Interleukin-6 in prostate cancer tissues and its effect on migration and evasiveness of cancer cells. Material and Methods: The releasing of Interleukin-6, Tumor necrosis factor-α in prostate cancer cells was detected by ELISA method. For prostate cancer cells after knockout, additional Interleukin-6 or Tumor necrosis factor-α induction was given in vitro. After 12 h of culture, the effects of Interleukin-6, Tumor necrosis factor-α on the migration and evasiveness of prostate cancer cells were observed by Western blot method and matrices invasion experiment. Results: The expression of epithelial mesenchymal transition-related proteins, the migration and invasion ability of prostate cancer cells in each gene knockout group were significantly reduced. After induction of inflammatory factors (Interleukin-6 or Tumor necrosis factor-α) in the gene knockout group for 12 h, the expression levels of epithelial mesenchymal transition-related proteins, the migration and aggressiveness of prostate cancer were significantly higher than those after knockout. Conclusion: Interleukin-6 and Tumor necrosis factor-α can induce epithelial mesenchymal transition in LNCaP and PC3 cells, promote cell invasion and metastasis, and provide a new direction for future research.

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