Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18

2012 ◽  
Vol 423 (3) ◽  
pp. 478-483 ◽  
Author(s):  
Yohei Matsunaga ◽  
Keiko Gengyo-Ando ◽  
Shohei Mitani ◽  
Takashi Iwasaki ◽  
Tsuyoshi Kawano
Keyword(s):  
Transcriptional Regulation ◽  
Caenorhabditis Elegans ◽  
Expression Pattern ◽  
Physiological Function ◽  
Function Expression

scholarly journals Complexity of Developmental Control: Analysis of Embryonic Cell Lineage Specification in Caenorhabditis elegans Using pes-1 as an Early Marker

Genetics ◽  
1999 ◽  
Vol 151 (1) ◽  
pp. 131-141
Author(s):  
Laurent Molin ◽  
Heinke Schnabel ◽  
Titus Kaletta ◽  
Richard Feichtinger ◽  
Ian A Hope ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Expression Pattern ◽  
Fusion Gene ◽  
Ectopic Expression ◽  
Gene Expression Pattern ◽  
Embryonic Cell ◽  
Control Analysis ◽  
Normal Pattern ◽  
Variable Expression ◽  
Founder Cells

Abstract In the early Caenorhabditis elegans embryo five somatic founder cells are born during the first cleavages. The first of these founder cells, named AB, gives rise to 389 of the 558 nuclei present in the hatching larva. Very few genes directly involved in the specification of the AB lineage have been identified so far. Here we describe a screen of a large collection of maternal-effect embryonic lethal mutations for their effect on the early expression of a pes-1::lacZ fusion gene. This fusion gene is expressed in a characteristic pattern in 14 of the 32 AB descendants present shortly after the initiation of gastrulation. Of the 37 mutations in 36 genes suspected to be required specifically during development, 12 alter the expression of the pes-1::lacZ marker construct. The gene expression pattern alterations are of four types: reduction of expression, variable expression, ectopic expression in addition to the normal pattern, and reduction of the normal pattern together with ectopic expression. We estimate that ∼100 maternal functions are required to establish the pes-1 expression pattern in the early embryo.

The physiological function of aerolysin-like protein Lin-24 in Caenorhabditis elegans

Toxicon ◽  
2019 ◽  
Vol 158 ◽  
pp. S87-S88
Author(s):  
Ming-Ming Zhao ◽  
Zhi-Hong Shi ◽  
Wen-Hui Lee ◽  
Yang Xiang ◽  
Yun Zhang
Keyword(s):  
Caenorhabditis Elegans ◽  
Physiological Function

ACaenorhabditis elegansInsulin-Like Peptide, INS-17: Its Physiological Function and Expression Pattern

2012 ◽  
Vol 76 (11) ◽  
pp. 2168-2172 ◽  
Author(s):  
Yohei MATSUNAGA ◽  
Kensuke NAKAJIMA ◽  
Keiko GENGYO-ANDO ◽  
Shohei MITANI ◽  
Takashi IWASAKI ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Physiological Function

scholarly journals Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans

2004 ◽  
Vol 378 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Christopher J. MEE ◽  
Simon R. TOMLINSON ◽  
Pavel V. PERESTENKO ◽  
David de POMERAI ◽  
Ian R. DUCE ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Drug Sensitivity ◽  
Physiological Function ◽  
High Molecular Mass ◽  
Spider Venom ◽  
Black Widow ◽  
Black Widow Spider ◽  
C Elegans ◽  
Black Widow Spider Venom ◽  
Widow Spider

Black widow spider venom (BWSV) kills Caenorhabditis elegans after injection owing to the presence of heat- and detergent-sensitive components, which are high-molecular-mass latrotoxins. A C. elegans homologue of latrophilin/CIRL (calcium-independent receptor for latrotoxin), B0457.1, was identified and shown to have five conserved domains. RNAi (RNA interference) of this gene rendered C. elegans resistant to BWSV, whereas RNAi for CYP37A1 or a neurexin I homologue, and a deletion mutant of the related B0286.2 gene, had no effect on BWSV toxicity. The latrophilin RNAi mutants exhibit changes in defaecation cycle and alterations in drug sensitivity. These results demonstrate that latrophilin mediates the toxicity of BWSV and provide evidence for a physiological function of this receptor.

scholarly journals Cytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly in Chlamydomonas

1999 ◽  
Vol 10 (3) ◽  
pp. 693-712 ◽  
Author(s):  
Mary E. Porter ◽  
Raqual Bower ◽  
Julie A. Knott ◽  
Pamela Byrd ◽  
William Dentler
Keyword(s):  
Caenorhabditis Elegans ◽  
Expression Pattern ◽  
Heavy Chain ◽  
Insertional Mutagenesis ◽  
Sea Urchins ◽  
Amorphous Material ◽  
Cytoplasmic Dynein ◽  
Genetic Approach ◽  
Dynein Heavy Chain ◽  
Flagellar Assembly

A second cytoplasmic dynein heavy chain (cDhc) has recently been identified in several organisms, and its expression pattern is consistent with a possible role in axoneme assembly. We have used a genetic approach to ask whether cDhc1b is involved in flagellar assembly in Chlamydomonas. Using a modified PCR protocol, we recovered two cDhc sequences distinct from the axonemal Dhc sequences identified previously. cDhc1a is closely related to the major cytoplasmic Dhc, whereas cDhc1b is closely related to the minor cDhc isoform identified in sea urchins, Caenorhabditis elegans, and Tetrahymena. TheChlamydomonas cDhc1b transcript is a low-abundance mRNA whose expression is enhanced by deflagellation. To determine its role in flagellar assembly, we screened a collection of stumpy flagellar (stf) mutants generated by insertional mutagenesis and identified two strains in which portions of the cDhc1bgene have been deleted. The two mutants assemble short flagellar stumps (<1–2 μm) filled with aberrant microtubules, raft-like particles, and other amorphous material. The results indicate that cDhc1b is involved in the transport of components required for flagellar assembly in Chlamydomonas.

Differential expression pattern of coq-8 gene during development in Caenorhabditis elegans

2006 ◽  
Vol 6 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Claudio Asencio ◽  
Juan Carlos Rodríguez-Aguilera ◽  
Rafael Vázquez ◽  
Howard Baylis ◽  
Juan Cabello ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Differential Expression ◽  
Expression Pattern ◽  
Differential Expression Pattern
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