A circulatory transcriptional regulation among daf-9, daf-12, and daf-16 mediates larval development upon cholesterol starvation in Caenorhabditis elegans†

2010 ◽  
Vol 239 (7) ◽  
pp. 1931-1940 ◽  
Author(s):  
Myung-Hwan Jeong ◽  
Ichiro Kawasaki ◽  
Yhong-Hee Shim
Keyword(s):  
Transcriptional Regulation ◽  
Caenorhabditis Elegans ◽  
Larval Development

scholarly journals NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development

2006 ◽  
Vol 123 (9) ◽  
pp. 689-701 ◽  
Author(s):  
Eva Brožová ◽  
Kateřina Šimečková ◽  
Zdeněk Kostrouch ◽  
Joseph Edward Rall ◽  
Marta Kostrouchová
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Nuclear Receptor ◽  
Early Larval Development

scholarly journals Maternal Caffeine Intake Disrupts Eggshell Integrity and Retards Larval Development by Reducing Yolk Production in a Caenorhabditis elegans Model

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1334 ◽  
Author(s):  
Hyemin Min ◽  
Esther Youn ◽  
Yhong-Hee Shim
Keyword(s):  
Growth Rate ◽  
Transcription Factor ◽  
Rna Interference ◽  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Caffeine Intake ◽  
Young Mother ◽  
Psychoactive Substance ◽  
Intergenerational Effects ◽  
F2 Generation

During pregnancy, most women are exposed to caffeine, which is a widely consumed psychoactive substance. However, the consequences of maternal caffeine intake on the child remain largely unknown. Here, we investigated the intergenerational effects of maternal caffeine intake on offspring in a Caenorhabditis elegans model. We treated a young mother (P0) with 10 mM of caffeine equivalent to 2–5 cans of commercial energy drinks and examined its reproduction and growth rate from P0 to F2 generation. The fertility decreased and embryonic lethality increased by defective oocytes and eggshell integrity in caffeine-ingested mothers, and F1 larval development severely retarded. These results were due to decreased production of vitellogenin protein (yolk) in caffeine-ingested mothers. Furthermore, effects of RNA interference of vitellogenin (vit) genes, vit-1 to vit-6, in P0 mothers can mimic those by caffeine-ingested mothers. In addition, RNA interference (RNAi) depletion of unc-62 (human Meis homeobox), a transcriptional activator for vit genes, also showed similar effects induced by caffeine intake. Taken together, maternal caffeine intake reduced yolk production mediated by the UNC-62 transcription factor, thereby disrupting oocyte and eggshell integrity and retarding larval development. Our study suggests the clinical significance of caffeine intake for prospective mothers.

scholarly journals Cholesterol-responsive metabolic proteins are required for larval development in Caenorhabditis elegans

2013 ◽  
Vol 36 (5) ◽  
pp. 410-416 ◽  
Author(s):  
Ichiro Kawasaki ◽  
Myung-Hwan Jeong ◽  
Yu-Joun Yun ◽  
Yun-Kyung Shin ◽  
Yhong-Hee Shim
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development

Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans

2014 ◽  
Vol 60 (1) ◽  
Author(s):  
Romina E. D’Almeida ◽  
María R. Alberto ◽  
Phillip Morgan ◽  
Margaret Sedensky ◽  
María I. Isla
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Free Living ◽  
Egg Hatching ◽  
C Elegans ◽  
Therapeutic Drugs ◽  
Aerial Parts ◽  
Free Living Nematode ◽  
Development Processes ◽  
Anthelmintic Effect

AbstractZuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2´,4´-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug.

scholarly journals Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans

Development ◽  
2008 ◽  
Vol 135 (13) ◽  
pp. 2239-2249 ◽  
Author(s):  
D. S. Patel ◽  
L. L. Fang ◽  
D. K. Svy ◽  
G. Ruvkun ◽  
W. Li
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Genetic Identification ◽  
Steroidogenic Enzyme

scholarly journals lin-35/Rb Cooperates With the SWI/SNF Complex to Control Caenorhabditis elegans Larval Development

Genetics ◽  
2004 ◽  
Vol 167 (3) ◽  
pp. 1177-1185 ◽  
Author(s):  
Mingxue Cui ◽  
David S. Fay ◽  
Min Han
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development
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