Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells

2011 ◽  
Vol 415 (4) ◽  
pp. 602-607 ◽  
Author(s):  
Sung-Whan Kim ◽  
Chae Eun Kim ◽  
Moo Hyun Kim
Keyword(s):  
Endothelial Cells ◽  
P38 Mapk ◽  
High Glucose ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

scholarly journals e0060 Resistin impairs fibrinolytic activity in human umbilical vein endothelial cells via p38 MAPK pathway

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A19-A19
Author(s):  
L. Yuguang ◽  
Z. Qin ◽  
L. Dan ◽  
Y. Haiyan ◽  
H. Jing ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
P38 Mapk ◽  
Fibrinolytic Activity ◽  
Mapk Pathway ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
P38 Mapk Pathway ◽  
Umbilical Vein Endothelial Cells

Hypoxia-induced Bcl-2 expression in endothelial cells via p38 MAPK pathway

2010 ◽  
Vol 394 (4) ◽  
pp. 976-980 ◽  
Author(s):  
Cui-Li Zhang ◽  
Fei Song ◽  
Jing Zhang ◽  
Q.H. Song
Keyword(s):  
Endothelial Cells ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells

Blood ◽  
2000 ◽  
Vol 95 (10) ◽  
pp. 3044-3051 ◽  
Author(s):  
Stefan Hippenstiel ◽  
Saskia Soeth ◽  
Birgit Kellas ◽  
Oliver Fuhrmann ◽  
Joachim Seybold ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
P38 Mapk ◽  
Messenger Rna ◽  
Mapk Pathway ◽  
Active Form ◽  
Interleukin 8 ◽  
Mitogen Activated Protein Kinase ◽  
Protein Accumulation ◽  
Rho Proteins ◽  
P38 Mapk Pathway

Bacterial endotoxin (lipopolysaccharide, or LPS) has potent proinflammatory properties by acting on many cell types, including endothelial cells. Secretion of the CXC-chemokine interleukin-8 (IL-8) by LPS-activated endothelial cells contributes substantially to the inflammatory response. Using human umbilical vein endothelial cells (HUVECs), we analyzed the role of small GTP-binding Rho proteins and p38 mitogen-activated protein kinase (MAPK) for LPS-dependent IL-8 expression in endothelial cells. Specific inactivation of RhoA/Cdc42/Rac1 by Clostridium difficile toxin B-10463 (TcdB-10463) reduced LPS-induced tyrosine phosphorylation, nuclear factor (NF)-κB–dependent gene expression, IL-8 messenger RNA, and IL-8 protein accumulation but showed no effect on LPS-dependent p38 MAPK activation. Inhibition of p38 MAPK by SB 202190 also blocked LPS-induced NF-κB activation and IL-8 synthesis. Furthermore, selective activation of the p38 MAPK pathway by transient expression of a constitutively active form of MAPK kinase (MKK)6, the upstream activator of p38, was as effective as LPS with respect to IL-8 expression in HUVECs. In summary, our data suggest that LPS-induced NF-κB activation and IL-8 synthesis in HUVECs are regulated by both a Rho-dependent signaling pathway and the MKK6/p38 kinase cascade.

Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells

2009 ◽  
Vol 124 (4) ◽  
pp. 439-446 ◽  
Author(s):  
Amandine Jaulmes ◽  
Patricia Sansilvestri-Morel ◽  
Gaëlle Rolland-Valognes ◽  
Fabienne Bernhardt ◽  
Roger Gaertner ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Plasminogen Activator ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Plasminogen Activator Inhibitor ◽  
Human Endothelial Cells ◽  
Plasminogen Activator Inhibitor 1 ◽  
P38 Mapk Pathway ◽  
Activator Inhibitor
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