Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism

2011 ◽  
Vol 413 (2) ◽  
pp. 330-335 ◽  
Author(s):  
Wataru Aoi ◽  
Yuji Naito ◽  
Liu Po Hang ◽  
Kazuhiko Uchiyama ◽  
Satomi Akagiri ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fatty Liver ◽  
Regular Exercise ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Effects of maternal high‐fat/high sucrose diet on hepatic lipid metabolism in rat offspring

2020 ◽  
Vol 48 (1) ◽  
pp. 86-95
Author(s):  
Camilla Ingvorsen ◽  
Christopher J. Lelliott ◽  
Susanne Brix ◽  
Lars I. Hellgren
Keyword(s):  
Lipid Metabolism ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Rat Offspring ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Muscle Lipid Metabolism and Insulin Secretion Are Altered in Insulin-Resistant Rats Fed a High Sucrose Diet

2003 ◽  
Vol 133 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Adriana Chicco ◽  
María Eugenia D'Alessandro ◽  
Liliana Karabatas ◽  
Claudia Pastorale ◽  
Juan Carlos Basabe ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Lipid Metabolism ◽  
Muscle Lipid ◽  
Insulin Resistant ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Aaron M. Gusdon ◽  
Ke-xiu Song ◽  
Shen Qu
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Signaling Pathways ◽  
Fatty Liver Disease ◽  
Beta Oxidation ◽  
Hepatic Lipid Metabolism ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Lipid

Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of disorders characterized by the accumulation of triglycerides within the liver. The global prevalence of NAFLD has been increasing as the obesity epidemic shows no sign of relenting. Mitochondria play a central role in hepatic lipid metabolism and also are affected by upstream signaling pathways involved in hepatic metabolism. This review will focus on the role of mitochondria in the pathophysiology of NAFLD and touch on some of the therapeutic approaches targeting mitochondria as well as metabolically important signaling pathways. Mitochondria are able to adapt to lipid accumulation in hepatocytes by increasing rates of beta-oxidation; however increased substrate delivery to the mitochondrial electron transport chain (ETC) leads to increased reactive oxygen species (ROS) production and eventually ETC dysfunction. Decreased ETC function combined with increased rates of fatty acid beta-oxidation leads to the accumulation of incomplete products of beta-oxidation, which combined with increased levels of ROS contribute to insulin resistance. Several related signaling pathways, nuclear receptors, and transcription factors also regulate hepatic lipid metabolism, many of which are redox sensitive and regulated by ROS.

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