Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage

2011 ◽  
Vol 409 (2) ◽  
pp. 350-355 ◽  
Author(s):  
Pan Yu ◽  
Zhenxiang Wang ◽  
Xuejun Sun ◽  
Xiaohua Chen ◽  
Suyun Zeng ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Human Skin ◽  
High Glucose ◽  
Skin Fibroblasts ◽  
Rich Medium ◽  
Human Skin Fibroblasts

Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts

2003 ◽  
Vol 35 (8) ◽  
pp. 910-921 ◽  
Author(s):  
Sharmila Basu-Modak ◽  
Matthew J Gordon ◽  
Laura H Dobson ◽  
Jeremy P.E Spencer ◽  
Catherine Rice-Evans ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

scholarly journals Exosomal MiR-769-5p Exacerbates Ultraviolet-Induced Bystander Effect by Targeting TGFBR1

2020 ◽  
Vol 11 ◽  
Author(s):  
Na Ni ◽  
Weiwei Ma ◽  
Yanling Tao ◽  
Juan Liu ◽  
Hui Hua ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Human Skin ◽  
Bystander Effect ◽  
Transforming Growth Factor ◽  
Underlying Mechanism ◽  
Skin Fibroblasts ◽  
Luciferase Reporter ◽  
Human Skin Fibroblasts ◽  
Bystander Effects ◽  
Damage Level

Exosomal microRNAs have been investigated in bystander effect, but it is unclear whether microRNA works in ultraviolet radiation–induced bystander effects (UV-RIBEs) and what the underlying mechanism could be. Exosomes from ultraviolet (UV)–irradiated human skin fibroblasts (HSFs) were isolated and transferred to normal HSFs, followed by the detection of proliferation rate, oxidative damage level, and apoptosis rate. Exosomal miRNAs were evaluated and screened with miRNA sequencing and quantitative reverse transcriptase–polymerase chain reaction method. MiRNA shuttle and bystander photodamage reactions were observed after transfection of miR-769-5p. MiR-769-5p targeting gene transforming growth factor-β1 (TGFBR1), and TGFBR1 mRNA 3′-untranslated region (UTR) was assessed and identified by Western blotting and dual-luciferase reporter assay. Bystander effects were induced after being treated with isolated exosomes from UV-irradiated HSFs. Exosomal miR-769-5p expression was significantly upregulated. Human skin fibroblasts showed lower proliferation, increasing oxidative damage, and faster occurrence of apoptosis after transfection. Exosome-mediated transfer of miR-769-5p was observed. Upregulation of miR-769-5p induced bystander effects, whereas downregulation of miR-769-5p can suppress UV-RIBEs. In addition, miR-769-5p was found to downregulate TGFBR1 gene expression by directly targeting its 3′-UTR. Our results demonstrate that exosome-mediated miR-769-5p transfer could function as an intercellular messenger and exacerbate UV-RIBEs. MiR-769-5p inhibits the expression of TGFBR1 by targeting TGFBR1 mRNA 3′-UTR.

Inhibitory effect of polypeptide from Chlamys farreri on ultraviolet A-induced oxidative damage on human skin fibroblasts in vitro

2004 ◽  
Vol 49 (3) ◽  
pp. 265-274 ◽  
Author(s):  
Yan-Tao Han ◽  
Zhi-Wu Han ◽  
Guo-Ying Yu ◽  
Yue-Jun Wang ◽  
Rui-Yao Cui ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Human Skin ◽  
Inhibitory Effect ◽  
Chlamys Farreri ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Ultraviolet A

Baicalin protects human skin fibroblasts from ultraviolet A radiation-induced oxidative damage and apoptosis

2012 ◽  
Vol 46 (12) ◽  
pp. 1458-1471 ◽  
Author(s):  
Bing-rong Zhou ◽  
Hui-bin Yin ◽  
Yang Xu ◽  
Di Wu ◽  
Zhao-hui Zhang ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Ultraviolet A ◽  
Radiation Induced

Restoration of myo-inositol uptake by eicosapentaenoic acid in human skin fibroblasts cultured in high-glucose medium

Life Sciences ◽  
1995 ◽  
Vol 57 (5) ◽  
pp. PL71-PL74 ◽  
Author(s):  
Yukichi Okuda ◽  
Toshie Sawada ◽  
Masakazu Mizutani ◽  
Hirohito Sone ◽  
Sciji Suzuki ◽  
...  
Keyword(s):  
Eicosapentaenoic Acid ◽  
Human Skin ◽  
High Glucose ◽  
Skin Fibroblasts ◽  
Glucose Medium ◽  
Human Skin Fibroblasts ◽  
High Glucose Medium ◽  
Inositol Uptake
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