Platelet activation during tumor development, the potential role of BDNF–TrkB autocrine loop

2006 ◽  
Vol 346 (3) ◽  
pp. 981-985 ◽  
Author(s):  
Zhen Fan Yang ◽  
David W. Ho ◽  
Chi Keung Lau ◽  
Ka Ho Tam ◽  
Chi Tat Lam ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Potential Role ◽  
Tumor Development ◽  
Autocrine Loop

scholarly journals Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 780
Author(s):  
Kishor Pant ◽  
Estanislao Peixoto ◽  
Seth Richard ◽  
Sergio A. Gradilone
Keyword(s):  
Histone Deacetylases ◽  
Potential Role ◽  
Chemotherapy Resistance ◽  
Tumor Development ◽  
Therapeutic Targets ◽  
Cellular Proteins ◽  
Epigenetic Changes ◽  
Post Translational Modifications ◽  
Frequent Relapse

Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many cellular proteins including histones may undergo a series of enzyme-mediated post-translational modifications including acetylation, methylation, phosphorylation, sumoylation, and crotonylation. Histone deacetylases (HDACs) play an important role in regulating epigenetic maintenance and modifications of their targets, which in turn exert critical impacts on chromatin structure, gene expression, and stability of proteins. As such, HDACs constitute a group of potential therapeutic targets for CCA. The aim of this review was to summarize the role that HDACs perform in regulating epigenetic changes, tumor development, and their potential as therapeutic targets for CCA.

scholarly journals Potential role of p62 in tumor development

Autophagy ◽  
2011 ◽  
Vol 7 (9) ◽  
pp. 1088-1090 ◽  
Author(s):  
Masaaki Komatsu
Keyword(s):  
Potential Role ◽  
Tumor Development

scholarly journals Markers of Angiogenesis in Ovarian Cancer

2007 ◽  
Vol 23 (5-6) ◽  
pp. 419-431 ◽  
Author(s):  
William M. Merritt ◽  
Anil K. Sood
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Carcinoma ◽  
Potential Role ◽  
Tumor Development ◽  
Prognostic Information ◽  
Angiogenic Therapy ◽  
Density Analysis ◽  
Monitoring Response ◽  
Potential Biomarkers

Tumor development and progression are inherently dependent on the process of angiogenesis. Recently, anti-angiogenic therapy has started to show promise as an effective treatment strategy in many solid tumors including ovarian carcinoma. Unfortunately, lack of effective biomarkers presents a challenge for oncologists in treatment planning as well as monitoring response of new anti-vascular agents. Previously, quantification of angiogenesis by microvessel density analysis provided useful prognostic information, however, its utility following anti-angiogenic therapy remains to be determined. Moreover, since secreted cytokines play an active part in angiogenesis by mediating neovascularization in tumors, investigations have focused on their potential role to serve as candidate biomarkers of disease detection, prognosis, and treatment response. In this article, we review the role of key angiogenesis markers as potential biomarkers in ovarian carcinoma.

scholarly journals The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging

2021 ◽  
Vol 11 ◽  
Author(s):  
Natarajan Bhaskaran ◽  
Sangeetha Jayaraman ◽  
Cheriese Quigley ◽  
Prerna Mamileti ◽  
Mahmoud Ghannoum ◽  
...  
Keyword(s):  
Potential Role ◽  
Tumor Development ◽  
Suppressor Cells ◽  
Tumor Burden ◽  
Aged Mice ◽  
Fungal Abundance ◽  
Tumor Immune Microenvironment ◽  
Deficient Mice ◽  
Partial Depletion

An increased accumulation of immune-dysfunction-associated CD4+Foxp3+ regulatory T cells (Tregs) is observed in aging oral mucosa during infection. Here we studied the function of Tregs during oral cancer development in aging mucosa. First, we found heightened proportions of Tregs and myeloid-derived suppressor cells (MDSC) accumulating in mouse and human oral squamous cell carcinoma (OSCC) tissues. Using the mouse 4-Nitroquinoline 1-oxide(4-NQO) oral carcinogenesis model, we found that tongues of aged mice displayed increased propensity for epithelial cell dysplasia, hyperplasia, and accelerated OSCC development, which coincided with significantly increased abundance of IL-1β, Tregs, and MDSC in tongues. Partial depletion of Tregs reduced tumor burden. Moreover, fungal abundance and dectin-1 signaling were elevated in aged mice suggesting a potential role for dectin-1 in modulating immune environment and tumor development. Confirming this tenet, dectin-1 deficient mice showed diminished IL-1β, reduced infiltration of Tregs and MDSC in the tongues, as well as slower progression and reduced severity of tumor burden. Taken together, these data identify an important role of dectin-1 signaling in establishing the intra-tumoral immunosuppressive milieu and promoting OSCC tumorigenesis in the context of aging.

scholarly journals Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Enli Yang ◽  
Xuan Wang ◽  
Zhiyuan Gong ◽  
Miao Yu ◽  
Haiwei Wu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Potential Role ◽  
Tumor Development ◽  
Underlying Mechanism ◽  
Metabolic Reprogramming ◽  
Diagnosis And Prognosis ◽  
Energy Demands

Abstract Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands. Recently, extracellular vesicles (EVs) known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment (TME). Meanwhile, the TME is a highly heterogeneous ecosystem incorporating cancer cells, fibroblasts, adipocytes, endothelial cells, mesenchymal stem cells, and extracellular matrix. Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells, which facilitate cancer progression, angiogenesis, metastasis, drug resistance, and immunosuppression by reprogramming the metabolism of cancer cells and their surrounding stromal cells. In this review, we present the role of exosomes in the TME and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming. In addition, we will also discuss the potential role of exosomes targeting metabolic process as biomarkers for tumor diagnosis and prognosis, and exosomes-mediated metabolic reprogramming as potential targets for cancer therapy. Furthermore, a better understanding of the link between exosomes and metabolic reprogramming, and their impact on cancer progression, would provide novel insights for cancer prevention and treatment in the future.

The role of helper innate lymphoid cells in cancer

Immunotherapy ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1067-1081 ◽  
Author(s):  
Shunfeng Hu ◽  
Xin Wang
Keyword(s):  
Immune Cells ◽  
Potential Role ◽  
Tumor Development ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Tumor Type ◽  
New Findings ◽  
Tumor Growth And Metastasis ◽  
Basic Features

Innate lymphoid cells (ILCs) are an emerging family of innate immune cells and have been found to have an important role in infection, inflammation and tissue repair. In particular, recent work has identified significant alterations of ILC responses in tumor patients, suggesting potential roles of ILCs in tumor development. In this paper, we have focused on the basic features of ILCs and their interaction with other immune cells. Importantly, as the role of cytotoxic natural killer cells, assigned to ILC1 family, in cancer has been well established, we have summarized the new findings that showcase the potential role and mechanism of helper ILCs in different tumors. Helper ILCs might promote or inhibit tumor growth and metastasis, which depends on tumor type and ILC subset.

scholarly journals The role of dectin-1 signaling in altering tumor immune microenvironment in the context of aging

2021 ◽  
Author(s):  
Natarajan Bhaskaran ◽  
Sangeetha Jayaraman ◽  
Cheriese Quigley ◽  
Prerna Mamileti ◽  
Mahmoud Ghannoum ◽  
...  
Keyword(s):  
Potential Role ◽  
Tumor Development ◽  
Suppressor Cells ◽  
Tumor Burden ◽  
Aged Mice ◽  
Fungal Abundance ◽  
Tumor Immune Microenvironment ◽  
Deficient Mice ◽  
Partial Depletion

AbstractAn increased accumulation of immune-dysfunction-associated CD4+Foxp3+ regulatory T cells (Tregs) is observed in aging oral mucosa during infection. Here we studied the function of Tregs during oral cancer development in aging mucosa. First, we found heightened proportions of Tregs and myeloid-derived suppressor cells (MDSC) accumulating in mouse and human oral squamous cell carcinoma (OSCC) tissues. Using the mouse 4-Nitroquinoline 1-oxide(4-NQO) oral carcinogenesis model, we found that tongues of aged mice displayed increased propensity for epithelial cell dysplasia, hyperplasia, and accelerated OSCC development, which coincided with significantly increased abundance of IL-1β, Tregs, and MDSC in tongues. Partial depletion of Tregs reduced tumor burden. Moreover, fungal abundance and dectin-1 signaling were elevated in aged mice suggesting a potential role for dectin-1 in modulating immune environment and tumor development. Confirming this tenet, dectin-1 deficient mice showed diminished IL-1β, reduced infiltration of Tregs and MDSC in the tongues, as well as slower progression and reduced severity of tumor burden. Taken together, these data identify an important role of dectin-1 signaling in establishing the intra-tumoral immunosuppressive milieu and promoting OSCC tumorigenesis in the context of aging.

scholarly journals Potential Role of the Inactivated X Chromosome in Ovarian Epithelial Tumor Development

1996 ◽  
Vol 88 (8) ◽  
pp. 510-518 ◽  
Author(s):  
P. C. Cheng ◽  
J. A. Gosewehr ◽  
T. M. Kim ◽  
M. Velicescu ◽  
M. Wan ◽  
...  
Keyword(s):  
X Chromosome ◽  
Potential Role ◽  
Tumor Development ◽  
Epithelial Tumor ◽  
Ovarian Epithelial Tumor

scholarly journals 2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory proteins

2009 ◽  
Vol 2 ◽  
pp. JCD.S2480
Author(s):  
Cara Horny ◽  
Muralimanoharan Sri Balasubashini ◽  
Krishna Komanduri ◽  
Manonmani Ganapathy ◽  
I-Tien Yeh ◽  
...  
Keyword(s):  
Potential Role ◽  
Tumor Development ◽  
Xenograft Model ◽  
Prostate Tumor ◽  
Regulatory Proteins ◽  
Tumor Growth Inhibition ◽  
Naturally Occurring ◽  
Low Concentrations ◽  
Wee1 Kinase

Nontoxic naturally occurring metabolite of estrogen namely 2-methoxyestradial (2ME2) found in serum and urine has been shown to be antitumorigenic in various tumor models including the prostate. A recent study conducted in breast cancer cells showed growth stimulatory effect of 2ME2 when used at low concentrations (10-750 nM). Studies from our laboratory has demonstrated prostate tumor preventive ability of 50 mg/kg 2-ME2. In this study we show that concentrations of 2-ME2 as low as 1 μM is sufficient to inhibit proliferation and induce apoptosis in androgen responsive LNCaP cells. In addition oral administration of doses lower than 50 mg/kg prevented prostate tumor development in LNCaP xenograft model. The observed tumor growth inhibition was associated with induction of apoptosis, increased expression of Wee1 kinase and p34cdc2. In addition administration of 25 mg/kg 2-ME2 prevented tumor development significantly that is associated with reduction in serum PSA levels.

The potential role of endothelial dysfunction and platelet activation in the development of thrombotic risk in COPD patients

2017 ◽  
Vol 10 (9) ◽  
pp. 821-832 ◽  
Author(s):  
Mario Malerba ◽  
Matteo Nardin ◽  
Alessandro Radaeli ◽  
Paolo Montuschi ◽  
Giovanna E Carpagnano ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Platelet Activation ◽  
Potential Role ◽  
Thrombotic Risk ◽  
Copd Patients
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