scholarly journals 2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory proteins

2009 ◽  
Vol 2 ◽  
pp. JCD.S2480
Author(s):  
Cara Horny ◽  
Muralimanoharan Sri Balasubashini ◽  
Krishna Komanduri ◽  
Manonmani Ganapathy ◽  
I-Tien Yeh ◽  
...  
Keyword(s):  
Potential Role ◽  
Tumor Development ◽  
Xenograft Model ◽  
Prostate Tumor ◽  
Regulatory Proteins ◽  
Tumor Growth Inhibition ◽  
Naturally Occurring ◽  
Low Concentrations ◽  
Wee1 Kinase

Nontoxic naturally occurring metabolite of estrogen namely 2-methoxyestradial (2ME2) found in serum and urine has been shown to be antitumorigenic in various tumor models including the prostate. A recent study conducted in breast cancer cells showed growth stimulatory effect of 2ME2 when used at low concentrations (10-750 nM). Studies from our laboratory has demonstrated prostate tumor preventive ability of 50 mg/kg 2-ME2. In this study we show that concentrations of 2-ME2 as low as 1 μM is sufficient to inhibit proliferation and induce apoptosis in androgen responsive LNCaP cells. In addition oral administration of doses lower than 50 mg/kg prevented prostate tumor development in LNCaP xenograft model. The observed tumor growth inhibition was associated with induction of apoptosis, increased expression of Wee1 kinase and p34cdc2. In addition administration of 25 mg/kg 2-ME2 prevented tumor development significantly that is associated with reduction in serum PSA levels.

scholarly journals Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 780
Author(s):  
Kishor Pant ◽  
Estanislao Peixoto ◽  
Seth Richard ◽  
Sergio A. Gradilone
Keyword(s):  
Histone Deacetylases ◽  
Potential Role ◽  
Chemotherapy Resistance ◽  
Tumor Development ◽  
Therapeutic Targets ◽  
Cellular Proteins ◽  
Epigenetic Changes ◽  
Post Translational Modifications ◽  
Frequent Relapse

Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many cellular proteins including histones may undergo a series of enzyme-mediated post-translational modifications including acetylation, methylation, phosphorylation, sumoylation, and crotonylation. Histone deacetylases (HDACs) play an important role in regulating epigenetic maintenance and modifications of their targets, which in turn exert critical impacts on chromatin structure, gene expression, and stability of proteins. As such, HDACs constitute a group of potential therapeutic targets for CCA. The aim of this review was to summarize the role that HDACs perform in regulating epigenetic changes, tumor development, and their potential as therapeutic targets for CCA.

scholarly journals Potential role of p62 in tumor development

Autophagy ◽  
2011 ◽  
Vol 7 (9) ◽  
pp. 1088-1090 ◽  
Author(s):  
Masaaki Komatsu
Keyword(s):  
Potential Role ◽  
Tumor Development

scholarly journals Interactions of C-reactive protein with the complement system. II. C-reactive protein-mediated consumption of complement by poly-L-lysine polymers and other polycations.

1975 ◽  
Vol 142 (3) ◽  
pp. 709-721 ◽  
Author(s):  
J Siegel ◽  
A P Osmand ◽  
M F Wilson ◽  
H Gewurz
Keyword(s):  
Inflammatory Response ◽  
Potential Role ◽  
Egg White ◽  
Phosphate Esters ◽  
C Reactive Protein ◽  
Cationic Proteins ◽  
Reactive Protein ◽  
Naturally Occurring ◽  
The Complement System

Cationic homopolymers of poly-L-lysine were found to activate complement (C) via C-reactive protein (CRP) and deplete C3 and C5 as well as early-acting C components. Maximum C consumption was obtained with polymers of 2,000-8,000 daltons; polymers of 1,700, 11,000, and 23,000 daltons were intermediate in reactivity, while L-lysine, lysyl-L-lysine, tetra-L-lysine, and polymers of 70,000-400,000 daltons lacked significant C-consuming activity. Naturally occurring polycations which consumed C in the presence of CRP included myelin basic proteins, cationic proteins of rabbit leukocytes, and both lysine- and arginine-rich histones; poly-L-arginine polymers of 17,000 but not 65,000 daltons also were C-consuming. Polycations without such reactivity included poly-L-orithine (5,000 and 165,000 daltons), egg white and human lysozymes, and Polybrene. The polycations which failed to induce C consumption via CRP, inhibited its consumption by both active polycations and by C-polysaccharide (CPS). The relative inhibitory capacity of phosphorylcholine and polycations in CPS- and polycations-CRP systems was consistent with the concept that phosphate esters and polycations react at the same or an overlapping combining site. The ability of certain polycations to activate C via CRP increases the potential for initiation of host reactions via C. The capacity of other polycations to inhibit C activation via CRP introduces a potential for physiologic or pharmacologic manipulation. These considerations would seem to expand the potential role of CRP in the initiation and modulation of the inflammatory response.

scholarly journals The Potential Role of Curcumin in Modulating the Master Antioxidant Pathway in Diabetic Hypoxia-Induced Complications

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7658
Author(s):  
Somayyeh Ghareghomi ◽  
Mahdie Rahban ◽  
Zainab Moosavi-Movahedi ◽  
Mehran Habibi-Rezaei ◽  
Luciano Saso ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Potential Role ◽  
Curcuma Longa ◽  
Redox Balance ◽  
Regulatory Proteins ◽  
Antioxidant Responses ◽  
Nrf2 Pathway ◽  
Pathway Regulation ◽  
Different Levels

Oxidative stress is the leading player in the onset and development of various diseases. The Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells’ redox balance. It decreases inflammation in which the nuclear trans-localization of Nrf2 as a transcription factor promotes various antioxidant responses in cells. Through some other directions and regulatory proteins, this pathway plays a fundamental role in preventing several diseases and reducing their complications. Regulation of the Nrf2 pathway occurs on transcriptional and post-transcriptional levels, and these regulations play a significant role in its activity. There is a subtle correlation between the Nrf2 pathway and the pivotal signaling pathways, including PI3 kinase/AKT/mTOR, NF-κB and HIF-1 factors. This demonstrates its role in the development of various diseases. Curcumin is a yellow polyphenolic compound from Curcuma longa with multiple bioactivities, including antioxidant, anti-inflammatory, anti-tumor, and anti-viral activities. Since hyperglycemia and increased reactive oxygen species (ROS) are the leading causes of common diabetic complications, reducing the generation of ROS can be a fundamental approach to dealing with these complications. Curcumin can be considered a potential treatment option by creating an efficient therapeutic to counteract ROS and reduce its detrimental effects. This review discusses Nrf2 pathway regulation at different levels and its correlation with other important pathways and proteins in the cell involved in the progression of diabetic complications and targeting these pathways by curcumin.

scholarly journals Potential role of hypothalamic microRNAs in regulation of FOS and FTO expression in response to hypoglycemia

2019 ◽  
Vol 69 (6) ◽  
pp. 981-991 ◽  
Author(s):  
Bashair M. Mussa ◽  
Jalal Taneera ◽  
Abdul Khader Mohammed ◽  
Ankita Srivastava ◽  
Debasmita Mukhopadhyay ◽  
...  
Keyword(s):  
Nervous System ◽  
Potential Role ◽  
Autonomic Failure ◽  
Regulatory Proteins ◽  
Molecular Signature ◽  
Regulatory Mechanisms ◽  
Dose Dependent Fashion ◽  
Sympathetic Nervous ◽  
Dose Dependent

AbstractHypoglycemia-associated autonomic failure (HAAF) is a serious complication of diabetes which is associated with the absence of physiological homeostatic counter-regulatory mechanisms that are controlled by the hypothalamus and sympathetic nervous system. Identification of biomarkers for early detection of HAAF requires an advanced understanding of molecular signature of hypoglycemia which is yet to be identified. The outcomes of the present study have shown that the viability and the apoptotic rate of the hypothalamic neurons (mHypoE-N39) were decreased significantly due to hypoglycemia in a dose-dependent fashion (p < 0.05). Although there are more than 1000 miRNAs differentially expressed in hypothalamus, only twelve miRNAs (miR-7a, miR-7b, miR-9, miR-29b, miR-29c, miR-30a, miR-30b, miR-30c, miR-101b-3p, miR-181a-5p, miR-378-3p and miR-873-5p) were correlated to two main hypothalamic regulatory proteins, FOS and FTO. Expression of these proteins was very sensitive to hypoglycemia. We demonstrated that hypoglycemia modulates the expression of hypothalamic miRNAs that are related to FOS and FTO.

scholarly journals THE ROLE OF GERONTOLOGICAL PSYCHOLOGY IN ACHIEVING THE UN’S SUSTAINABLE DEVELOPMENT GOALS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S75-S76
Author(s):  
Toni C Antonucci
Keyword(s):  
Sustainable Development ◽  
Sustainable Development Goals ◽  
Potential Role ◽  
Well Being ◽  
Naturally Occurring ◽  
Poverty And Inequality ◽  
Development Goals ◽  
The Individual ◽  
Health And Well Being

Abstract The United Nations has identified 17 Sustainable Development Goals (SDGs) designed to improve the health and well-being of the world’s most vulnerable populations. This presentation will review the potential role psychology, in particular, illustrative theories and research, in achieving the SDGs of reducing poverty and achieving gender equality and empowerment. We consider life span (individual) developmental and life course (environmental structure) theories as useful for explaining how poverty and inequality influence the individual and community at one point in time and over time. Further, we use research evidence to illustrate how naturally occurring resources can be garnered to better explain, understand, identify and create successful intervention programs. We emphasize the importance psychology to achieving SDGs and emphasize that the application psychology to changing the behavior and expectations of individuals and societies to achieve sustainable development that contributes to a world that celebrates optimal and sustainable development for all.

scholarly journals Markers of Angiogenesis in Ovarian Cancer

2007 ◽  
Vol 23 (5-6) ◽  
pp. 419-431 ◽  
Author(s):  
William M. Merritt ◽  
Anil K. Sood
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Carcinoma ◽  
Potential Role ◽  
Tumor Development ◽  
Prognostic Information ◽  
Angiogenic Therapy ◽  
Density Analysis ◽  
Monitoring Response ◽  
Potential Biomarkers

Tumor development and progression are inherently dependent on the process of angiogenesis. Recently, anti-angiogenic therapy has started to show promise as an effective treatment strategy in many solid tumors including ovarian carcinoma. Unfortunately, lack of effective biomarkers presents a challenge for oncologists in treatment planning as well as monitoring response of new anti-vascular agents. Previously, quantification of angiogenesis by microvessel density analysis provided useful prognostic information, however, its utility following anti-angiogenic therapy remains to be determined. Moreover, since secreted cytokines play an active part in angiogenesis by mediating neovascularization in tumors, investigations have focused on their potential role to serve as candidate biomarkers of disease detection, prognosis, and treatment response. In this article, we review the role of key angiogenesis markers as potential biomarkers in ovarian carcinoma.

scholarly journals The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging

2021 ◽  
Vol 11 ◽  
Author(s):  
Natarajan Bhaskaran ◽  
Sangeetha Jayaraman ◽  
Cheriese Quigley ◽  
Prerna Mamileti ◽  
Mahmoud Ghannoum ◽  
...  
Keyword(s):  
Potential Role ◽  
Tumor Development ◽  
Suppressor Cells ◽  
Tumor Burden ◽  
Aged Mice ◽  
Fungal Abundance ◽  
Tumor Immune Microenvironment ◽  
Deficient Mice ◽  
Partial Depletion

An increased accumulation of immune-dysfunction-associated CD4+Foxp3+ regulatory T cells (Tregs) is observed in aging oral mucosa during infection. Here we studied the function of Tregs during oral cancer development in aging mucosa. First, we found heightened proportions of Tregs and myeloid-derived suppressor cells (MDSC) accumulating in mouse and human oral squamous cell carcinoma (OSCC) tissues. Using the mouse 4-Nitroquinoline 1-oxide(4-NQO) oral carcinogenesis model, we found that tongues of aged mice displayed increased propensity for epithelial cell dysplasia, hyperplasia, and accelerated OSCC development, which coincided with significantly increased abundance of IL-1β, Tregs, and MDSC in tongues. Partial depletion of Tregs reduced tumor burden. Moreover, fungal abundance and dectin-1 signaling were elevated in aged mice suggesting a potential role for dectin-1 in modulating immune environment and tumor development. Confirming this tenet, dectin-1 deficient mice showed diminished IL-1β, reduced infiltration of Tregs and MDSC in the tongues, as well as slower progression and reduced severity of tumor burden. Taken together, these data identify an important role of dectin-1 signaling in establishing the intra-tumoral immunosuppressive milieu and promoting OSCC tumorigenesis in the context of aging.

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