Medial preoptic estrogen receptor-beta blunts the estrogen receptor-alpha mediated increases in wheel-running behavior of female rats

2020 ◽  
Vol 379 ◽  
pp. 112341
Author(s):  
Kolter B. Grigsby ◽  
Cathleen M. Kovarik ◽  
Xuansong Mao ◽  
Frank W. Booth
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Wheel Running ◽  
Estrogen Receptor Beta ◽  
Female Rats ◽  
Receptor Alpha ◽  
Receptor Beta

scholarly journals Calcium and Phosphorus Levels in Saliva are Influenced by Genetic Polymorphisms in Estrogen Receptor Alpha and Microrna17

2020 ◽  
Vol 31 (5) ◽  
pp. 466-470
Author(s):  
Erika Calvano Küchler ◽  
Raquel Fernanda Gerlach ◽  
Arthur S Cunha ◽  
Lucas A Ramazzotto ◽  
Paula Porto Spada ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Genetic Polymorphisms ◽  
Estrogen Receptor Alpha ◽  
Estrogen Receptor Beta ◽  
Chi Square ◽  
Receptor Alpha ◽  
High Calcium ◽  
Calcium And Phosphorus ◽  
Receptor Beta ◽  
Phosphorus Levels

Abstract Homeostasis between salivary calcium and phosphorus is important for maintaining oral health. The aim of this study was to evaluate if polymorphisms in ESR1 (Estrogen Receptor Alpha), ESR2 (Estrogen Receptor Beta) and miRNA17 (microRNA17) are associated with calcium and phosphorus levels in saliva. Saliva from 276 12-year-old children were collected by masticatory stimulation and calcium and phosphorus levels were determined by Mass Spectrometry. Genomic DNA was extracted from remaining saliva and genetic polymorphisms in ESR1 (rs12154178, rs1884051, rs9340799 and rs2234693), in ESR2 (rs4986938 and rs1256049) and in miRNA17 (rs4284505) were genotyped using TaqMan chemistry and a real-time PCR equipment. Statistical differences in genotype and allele distributions between ‘low’ and ‘high’ calcium and phosphorus levels were determined using chi-square or Fisher´s exact tests. The analysis was also adjusted by sex (alpha of 5%). ESR1 rs9340799 had the less common genotype associated with higher calcium levels (p=0.03). The less common allele of ESR1 rs1884051 was associated with lower phosphorus levels (p=0.005) and there was an excess of heterozygotes for miRNA17 rs4284505 among individuals with lower calcium levels (p=0.002), both adjusted by sex. This study provides evidence that genetic polymorphisms in ESR1 and miRNA17 are involved in determining salivary calcium and phosphorus levels.

Assessment of the Levels of ER and PR v1

2021 ◽  
Author(s):  
Dhimas Hari Sakti
Keyword(s):  
Polymerase Chain Reaction ◽  
Estrogen Receptor ◽  
Real Time ◽  
Estrogen Receptor Alpha ◽  
Estrogen Receptor Beta ◽  
Chain Reaction ◽  
Receptor Alpha ◽  
Polymerase Chain ◽  
Receptor Beta

Measuring the level of estrogen receptor alpha, estrogen receptor beta, and progesteron receptor in meningioma tissue using quantitative real-time polymerase chain reaction.

scholarly journals Association of genetic polymorphisms of estrogen and progesterone receptors and endometriosis: Meta-analysis

2019 ◽  
Vol 11 (1) ◽  
pp. 25-36
Author(s):  
Priscila Prais Carneiro ◽  
Bruna Vicente de Oliveira ◽  
Antonio Marcio Teodoro Cordeiro Silva
Keyword(s):  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Estrogen Receptor Alpha ◽  
Meta Analysis ◽  
Estrogen Receptor Beta ◽  
Progesterone Receptors ◽  
Estrogen And Progesterone Receptors ◽  
Receptor Alpha ◽  
Pubmed Database ◽  
Receptor Beta

Purpose: To investigate the association between polymorphisms in the genes of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor and the genesis of endometriosis. Methods: Systematic review and meta-analysis of articles published fully in the PubMed database, in Portuguese, English, or Spanish, from 2006 to 2017, using the descriptors: “endometriosis,” “polymorphism,” “ESR1,” “ESR2,” “PROGINS,” “rs9340799,” “rs4986938,” and “rs1042838.” Results: A total of 20 studies were included based on the criterion of search for susceptibility to endometriosis related to polymorphisms of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor genes. Analysis of all polymorphisms found no association with endometriosis. Conclusion: This meta-analysis showed that estrogen receptor alpha, estrogen receptor beta, and progesterone receptor polymorphisms are not related to susceptibility to endometriosis. However, such results may be able to provide more detailed interpretations of how they influence the pathogenesis of endometriosis.

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