Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia

2019 ◽  
Vol 364 ◽  
pp. 225-232 ◽  
Author(s):  
Yafei Kang ◽  
Kexin Huang ◽  
Yahui Lv ◽  
Wei Zhang ◽  
Suping Cai ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
First Episode ◽  
Genetic Contribution ◽  
Functional Changes ◽  
Dorsolateral Prefrontal ◽  
First Episode Schizophrenia

scholarly journals Changes in distributed neural circuitry function in patients with first-episode schizophrenia

2004 ◽  
Vol 185 (3) ◽  
pp. 205-214 ◽  
Author(s):  
A. Mendrek ◽  
K. R. Laurens ◽  
K. A. Kiehl ◽  
E. T. C. Ngan ◽  
E. Stip ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Memory Task ◽  
First Episode ◽  
Related Phenomenon ◽  
Cingulate Gyrus ◽  
Dorsolateral Prefrontal ◽  
Stable Characteristic ◽  
The Right ◽  
First Episode Schizophrenia

BackgroundA number of functional brain abnormalities have been reported in schizophrenia, but it remains to be determined which of them represent trait and state markers of the illness.AimsTo delineate regional brain dysfunctions that remain stable and those that fluctuate during the course of schizophrenia.MethodA cohort of patients with first-episode schizophrenia and a matched group of control participants underwent functional magnetic resonance imaging on two occasions 6–8 weeks apart during performance of a working memory task. The patients' disease was in partial remission at the second scan.ResultsRelative to control participants, the function of the left dorsolateral prefrontal cortex, left thalamus and right cerebellum remained disturbed in the people with schizophrenia, whereas the dysfunction of the right dorsolateral prefrontal cortex, right thalamus, left cerebellum and cingulate gyrus normalised, with significant reduction in symptoms.ConclusionsThese results suggest that dysfunction of the left fronto-thalamo-cerebellar circuitry is a relatively stable characteristic of schizophrenia, whereas disturbance of the right circuitry and cingulate gyrus is predominantly a state-related phenomenon.

scholarly journals Proactive and reactive cognitive control and dorsolateral prefrontal cortex dysfunction in first episode schizophrenia

2013 ◽  
Vol 2 ◽  
pp. 590-599 ◽  
Author(s):  
Tyler A. Lesh ◽  
Andrew J. Westphal ◽  
Tara A. Niendam ◽  
Jong H. Yoon ◽  
Michael J. Minzenberg ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Cognitive Control ◽  
Dorsolateral Prefrontal Cortex ◽  
First Episode ◽  
Dorsolateral Prefrontal ◽  
First Episode Schizophrenia
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