Maternal immune activation in mid-late gestation alters amphetamine sensitivity and object recognition, but not other schizophrenia-related behaviours in adult rats

2019 ◽  
Vol 356 ◽  
pp. 358-364 ◽  
Author(s):  
A. Gray ◽  
R. Tattoli ◽  
A. Dunn ◽  
D.M. Hodgson ◽  
P.T. Michie ◽  
...  
Keyword(s):  
Object Recognition ◽  
Immune Activation ◽  
Late Gestation ◽  
Adult Rats ◽  
Maternal Immune Activation

Increased cell-mediated immunity in male mice offspring exposed to maternal immune activation during late gestation

2013 ◽  
Vol 17 (3) ◽  
pp. 633-637 ◽  
Author(s):  
Adriano Zager ◽  
Milena Lobão Pinheiro ◽  
Viviane Ferraz-de-Paula ◽  
Alison Ribeiro ◽  
João Palermo-Neto
Keyword(s):  
Immune Activation ◽  
Late Gestation ◽  
Cell Mediated Immunity ◽  
Male Mice ◽  
Maternal Immune Activation

scholarly journals Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioural, and transcriptional study

2020 ◽  
Author(s):  
Elisa Guma ◽  
Pedro Bordignon ◽  
Gabriel Allan Devenyi ◽  
Daniel Gallino ◽  
Chloe Anastassiadis ◽  
...  
Keyword(s):  
Immune Activation ◽  
Neurodevelopmental Disorders ◽  
Dorsal Hippocampus ◽  
Early Adulthood ◽  
Sensorimotor Gating ◽  
Cingulate Cortex ◽  
Late Gestation ◽  
Anterior Cingulate ◽  
Poly I:C ◽  
Maternal Immune Activation

Prenatal maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders. How gestational timing of MIA-exposure differentially impacts downstream development remains unclear. Here, we characterize neurodevelopmental trajectories of mice exposed to MIA induced by poly I:C either early (gestational day [GD]9) or late (GD17) in gestation using longitudinal structural magnetic resonance imaging from weaning to adulthood. Early MIA-exposure associated with accelerated brain volume increases in adolescence/early-adulthood that normalized in later adulthood, in regions including the striatum, hippocampus, and cingulate cortex. Similarly, alterations in anxiety, stereotypic, and sensorimotor gating behaviours observed in adolescence normalized in adulthood. In contrast, MIA-exposure in late gestation had less impact on anatomical and behavioural profiles. Using a multivariate technique to relate imaging and behavioural variables for the time of greatest alteration, i.e. adolescence/early adulthood, we demonstrate that variation in anxiety, social, and sensorimotor gating associates significantly with volume of regions including the dorsal and ventral hippocampus, and anterior cingulate cortex. Using RNA sequencing to explore the molecular underpinnings of region-specific alterations in early MIA-exposed mice in adolescence, we observed the most transcriptional changes in the dorsal hippocampus, with regulated genes enriched for fibroblast growth factor regulation, autistic behaviours, inflammatory pathways, and microRNA regulation. This indicates that MIA in early gestation perturbs brain development mechanisms implicated in neurodevelopmental disorders. Our findings demonstrate the power of an integrated hypothesis- and data-driven approach in linking brain-behavioural alterations to the transcriptome to understand how MIA confers risk for major mental illness.

Maternal immune activation induced by lipopolysaccharide triggers immune response in pregnant mother and fetus, and induces behavioral impairment in adult rats

2018 ◽  
Vol 100 ◽  
pp. 71-83 ◽  
Author(s):  
Lutiana Roque Simões ◽  
Gustavo Sangiogo ◽  
Michael Hikaru Tashiro ◽  
Jaqueline S. Generoso ◽  
Cristiano Julio Faller ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Activation ◽  
Pregnant Mother ◽  
Behavioral Impairment ◽  
Adult Rats ◽  
Maternal Immune Activation

scholarly journals Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation

2015 ◽  
Vol 168 (1-2) ◽  
pp. 411-420 ◽  
Author(s):  
Ann M. Hemmerle ◽  
Rebecca Ahlbrand ◽  
Stefanie L. Bronson ◽  
Kerstin H. Lundgren ◽  
Neil M. Richtand ◽  
...  
Keyword(s):  
Immune Activation ◽  
Adult Rats ◽  
Maternal Immune Activation
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