Differential effects of maternal immune activation and juvenile stress on anxiety-like behaviour and physiology in adult rats: No evidence for the “double-hit hypothesis”

2011 ◽  
Vol 224 (1) ◽  
pp. 180-188 ◽  
Author(s):  
Nicole Yee ◽  
Adema Ribic ◽  
Christina Coenen de Roo ◽  
Eberhard Fuchs
Keyword(s):  
Immune Activation ◽  
Adult Rats ◽  
Differential Effects ◽  
Maternal Immune Activation ◽  
Double Hit

scholarly journals Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment

2021 ◽  
Author(s):  
Elisa Guma ◽  
Maude Bordeleau ◽  
Emily Snook ◽  
Gabriel Desrosiers-Gregoire ◽  
Fernando Gonzalez Ibanez ◽  
...  
Keyword(s):  
Immune Activation ◽  
Ex Vivo ◽  
Apoptotic Cell ◽  
Imaging Techniques ◽  
Differential Effects ◽  
Maternal Immune Activation ◽  
Late Exposure ◽  
Magnetic Resonance Imaging Mri ◽  
And Oxidative Stress ◽  
Embryo Brain

Exposure to maternal immune activation (MIA) in utero is a risk factor for neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult offspring have been well characterized, however, less is known about the effects of MIA-exposure on embryo development. To address this gap, we performed high-resolution ex vivo magnetic resonance imaging (MRI) to investigate the effects of early (gestational day [GD]9) and late (GD17) MIA-exposure on embryo (GD18) brain structure. We identify striking neuroanatomical changes in the embryo brain, particularly in the late exposed offspring. We further examined hippocampal neuroanatomy using electron microscopy and identified differential effects due to MIA-timing. An increase in apoptotic cell density was observed in the GD9 exposed offspring, while an increase in the density of dark neurons and glia, putative markers for increased neuroinflammation and oxidative stress, was observed in GD17 exposed offspring, particularly in females. Overall, our findings integrate imaging techniques across different scales to identify differential impact of MIA-timing on the earliest stages of neurodevelopment.

Maternal immune activation induced by lipopolysaccharide triggers immune response in pregnant mother and fetus, and induces behavioral impairment in adult rats

2018 ◽  
Vol 100 ◽  
pp. 71-83 ◽  
Author(s):  
Lutiana Roque Simões ◽  
Gustavo Sangiogo ◽  
Michael Hikaru Tashiro ◽  
Jaqueline S. Generoso ◽  
Cristiano Julio Faller ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Activation ◽  
Pregnant Mother ◽  
Behavioral Impairment ◽  
Adult Rats ◽  
Maternal Immune Activation

scholarly journals Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation

2015 ◽  
Vol 168 (1-2) ◽  
pp. 411-420 ◽  
Author(s):  
Ann M. Hemmerle ◽  
Rebecca Ahlbrand ◽  
Stefanie L. Bronson ◽  
Kerstin H. Lundgren ◽  
Neil M. Richtand ◽  
...  
Keyword(s):  
Immune Activation ◽  
Adult Rats ◽  
Maternal Immune Activation
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