scholarly journals Analysis of inflammation-induced depression of home cage wheel running in rats reveals the difference between opioid antinociception and restoration of function

2017 ◽  
Vol 317 ◽  
pp. 502-507 ◽  
Author(s):  
Ram Kandasamy ◽  
Jonas J. Calsbeek ◽  
Michael M. Morgan
Keyword(s):  
Home Cage ◽  
Wheel Running ◽  
The Difference ◽  
Opioid Antinociception

Effects of Prior Food Competition On the Rat's Killing Response To the White Mouse

Behaviour ◽  
1961 ◽  
Vol 17 (2-3) ◽  
pp. 95-101 ◽  
Author(s):  
Grant Newton ◽  
Norman W. Heimstra
Keyword(s):  
Home Cage ◽  
Food Competition ◽  
White Mouse ◽  
Control Group ◽  
Albino Rats ◽  
Test Situation ◽  
Dominance Relationship ◽  
Dominance Test ◽  
The Difference ◽  
Killing Response

AbstractForty male albino rats were paired and given 15 trials in a dominance test situation where only one animal in a pair could eat at a given time. Length of time in control of the food and frequency of dominant gestures and failures, which involved either success or failure in displacing the other animal from the food source, were the criteria employed in determining the dominance relationship within a pair of animals. A second group of 20 animals, of the same age and strain, did not receive the competitive experience and served as a control group. The day following the termination of the dominance trials, an adult albino mouse was placed in the home cage of each rat in both groups. Results showed that: I. None of the rats in the non-competitive control group killed the mouse they were paired with. 2. Twenty-two of the rats in the competitive group killed. 3. Sixteen of the killer rats in the competitive group were dominant animals while only six were submissive. The results are explained as being due to the difference in past experience of the two groups of rats.

Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion

2005 ◽  
Vol 160 (2) ◽  
pp. 382-388 ◽  
Author(s):  
Leonie de Visser ◽  
Ruud van den Bos ◽  
Berry M. Spruijt
Keyword(s):  
Home Cage ◽  
Wheel Running ◽  
Cage Floor

scholarly journals On the Digital Psychopharmacology of Valproic Acid in Mice

2020 ◽  
Author(s):  
John Samuel Bass ◽  
Anney Tuo ◽  
Linh Ton ◽  
Miranda J. Jankovic ◽  
Paarth K. Kapadia ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Open Field ◽  
Developmental Delays ◽  
Home Cage ◽  
Wheel Running ◽  
Drug Discontinuation ◽  
Fetal Exposure ◽  
Daily Ingestion ◽  
Field Assay ◽  
Technical Advances

AbstractObjectiveAntiepileptic drugs (AEDs) require daily ingestion for maximal seizure prophylaxis. Adverse psychiatric consequences of AEDs present as: (i) reversible changes in mood, anger, anxiety and/or irritability that often necessitate drug discontinuation, and (ii) autism and/or cognitive/psychomotor developmental delays following fetal exposure. Technical advances in quantifying naturalistic rodent behaviors may provide sensitive preclinical estimates of AED psychiatric tolerability and neuropsychiatric teratogenicity.MethodsUsing instrumented home-cage monitoring, we assessed how valproic acid (VPA, dissolved in sweetened drinking water) alters home-cage behavior in adult C57BL/6J mice and in the adult offspring of VPA-exposed breeder pairs. By utilizing a pup open field assay, we also examined how prenatal VPA exposure impacts early spontaneous exploratory behavior.ResultsAt 500-600mg/kg/d, chronic VPA produced hyperphagia and increased wheel-running without impacting sleep, activity and measures of risk aversion. When applied chronically to breeder pairs of mice, VPA prolonged the latency to viable litters without affecting litter size. Two-week old VPA-exposed pups displayed open field hypoactivity without alterations in thigmotaxis. As adults, prenatal VPA-exposed mice displayed active state fragmentation, hypophagia and increased wheel running, together with subtle alterations in home-cage dyadic behavior.InterpretationThrough automated home-cage assessments of C57BL/6J mice, we capture an ethologically centered psychopharmacological profile of enterally administered VPA that is aligned with human clinical experience. By characterizing the effects of pangestational VPA exposure, we discover novel murine expressions of pervasive neurodevelopment. Incorporating rigorous comprehensive assessments of neuropsychiatric tolerability may inform the design of future AEDs with improved neuropsychiatric safety profiles, both for patients and their offspring.

scholarly journals Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppression

2001 ◽  
Vol 281 (2) ◽  
pp. R484-R489 ◽  
Author(s):  
Albert Moraska ◽  
Monika Fleshner
Keyword(s):  
Physical Activity ◽  
Home Cage ◽  
Wheel Running ◽  
Negative Impact ◽  
Keyhole Limpet Hemocyanin ◽  
Sprague Dawley ◽  
Physically Active ◽  
Behavioral Depression ◽  
Sprague Dawley Rats ◽  
Voluntary Physical Activity

The current study addressed whether physical activity can buffer stress-induced “behavioral depression” and immunosuppression. Adult, male Sprague-Dawley rats were housed with either a mobile (physically active) or immobile (sedentary) running wheel and exposed to either stress (inescapable tail shock) or no stress (home cage control). Voluntary wheel running began 4 wk before stressor exposure. Immediately before stress, all rats were administered an intraperitoneal injection of keyhole limpet hemocyanin (KLH; 200 μg), and anti-KLH Ig was measured weekly for 4 wk using ELISA. Prior physical activity reduced the stress-induced behavioral depression and prevented the stress-induced suppression of anti-KLH IgM and IgG2a antibodies. Anti-KLH IgG1 was stress insensitive. These data suggest that physical activity can buffer the negative impact of stress on behavior and acquired immune function.

scholarly journals Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation

2014 ◽  
Vol 7 (3) ◽  
pp. 397-407 ◽  
Author(s):  
S. Mandillo ◽  
I. Heise ◽  
L. Garbugino ◽  
G. P. Tocchini-Valentini ◽  
A. Giuliani ◽  
...  
Keyword(s):  
Home Cage ◽  
Wheel Running ◽  
Motor Deficits ◽  
Disease Models ◽  
System A ◽  
Running System
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