scholarly journals Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation

2014 ◽  
Vol 7 (3) ◽  
pp. 397-407 ◽  
Author(s):  
S. Mandillo ◽  
I. Heise ◽  
L. Garbugino ◽  
G. P. Tocchini-Valentini ◽  
A. Giuliani ◽  
...  
Keyword(s):  
Home Cage ◽  
Wheel Running ◽  
Motor Deficits ◽  
Disease Models ◽  
System A ◽  
Running System

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Nature ◽  
2007 ◽  
Vol 445 (7128) ◽  
pp. 643-647 ◽  
Author(s):  
Anatol C. Kreitzer ◽  
Robert C. Malenka
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Deficits ◽  
Disease Models

scholarly journals SiamBOMB: A Real-time AI-based System for Home-cage Animal Tracking, Segmentation and Behavioral Analysis

2020 ◽  
Author(s):  
Xi Chen ◽  
Hao Zhai ◽  
Danqian Liu ◽  
Weifu Li ◽  
Chaoyue Ding ◽  
...  
Keyword(s):  
Behavior Analysis ◽  
Real Time ◽  
Animal Behavior ◽  
Home Cage ◽  
Modular Design ◽  
Behavioral Analysis ◽  
Animal Tracking ◽  
System A ◽  
User Friendly

Biologists often need to handle numerous video-based home-cage animal behavior analysis tasks that require massive workloads. Therefore, we develop an AI-based multi-species tracking and segmentation system, SiamBOMB, for real-time and automatic home-cage animal behavioral analysis. In this system, a background-enhanced Siamese-based network with replaceable modular design ensures the flexibility and generalizability of the system, and a user-friendly interface makes it convenient to use for biologists. This real-time AI system will effectively reduce the burden on biologists.

scholarly journals SISTEM INFORMASI PROFIL MAHASISWA PADA PENILAIAN PENGUJI PESSTA+ DI PERGURUAN TINGGI

2019 ◽  
Vol 5 (1) ◽  
pp. 76-88
Author(s):  
Hani Dewi Ariessanti ◽  
Aris Martono ◽  
Danang Suprayogi
Keyword(s):  
Information System ◽  
Assessment System ◽  
Observational Research ◽  
Profile Information ◽  
Student Profile ◽  
Final Project ◽  
System A ◽  
Running System ◽  
Lack Of Information ◽  
Student Profiles

Submission of information is an important thing in a system. A good system that is able to communicate to its users by conveying information correctly and clearly. In the examiner rating system found in Raharja College before the system still did not provide information about theprofile of the Thesis and Final Project students. Submitting the lack of information is felt to make the previously running system unable to communicate to its users. Therefore it is necessary to develop a student profile information system so that it can communicate to its usersclearly. After the examiner assessment system that has been developed becomes online, the student profile information system is also developed online by adding some information that can make the system more communicating to its users. Research to develop a student profile information system on the assessment of trial examiners using observational research methods, interviews and literature studies. The researcher made observations by looking at the shortcomings of the system, then conducting interviews with stakeholders, then the researchers sought similar research in order to solve the problems that had been obtained. It is expected that after being applied to the Testing Assessment system, the delivery of information regarding the profile of the Thesis trial and Final Project students can be better and clearer. Because information about student profiles is very important for examiners in providing trial scores to Thesis and Final Project students.

Changing a running system: A guideline for retrofitting brownfield manufacturing systems

2021 ◽  
Author(s):  
Natalie Samanta Nowacki ◽  
Klaus-Christoph Ritter ◽  
Arndt Luder ◽  
Anna-Kristin Behnert
Keyword(s):  
Manufacturing Systems ◽  
System A ◽  
Running System

scholarly journals Regulation of Reentrainment Function Is Dependent on a Certain Minimal Number of Intact Functional ipRGCs in rd Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Jingxue Zhang ◽  
Huaizhou Wang ◽  
Shen Wu ◽  
Qian Liu ◽  
Ningli Wang
Keyword(s):  
Wheel Running ◽  
Ganglion Cells ◽  
Survival Rates ◽  
Control Group ◽  
Dependent Manner ◽  
Retinal Ganglion ◽  
Dark Cycle ◽  
Visual Functions ◽  
Running System ◽  
Dose Dependent

Purpose. To investigate the effect of partial ablation of melanopsin-containing retinal ganglion cells (mcRGCs) on nonimage-forming (NIF) visual functions in rd mice lacking rods.Methods. The rd mice were intravitreally injected with different doses (100 ng/μl, 200 ng/μl, and 400 ng/μl) of immunotoxin melanopsin-SAP. And then, the density of ipRGCs was examined. After establishing the animal models with different degrees of ipRGC damage, a wheel-running system was used to evaluate their reentrainment response.Results. Intravitreal injection of melanopsin-SAP led to partial ablation of ipRGCs in a dose-dependent manner. The survival rates of ipRGCs in the 100 ng/μl, 200 ng/μl, and 400 ng/μl groups were 74.14% ± 4.15%, 39.25% ± 2.29%, and 38.38% ± 3.74%, respectively. The wheel-running experiments showed that more severe ipRGC loss was associated with a longer time needed for reentrainment. When the light/dark cycle was delayed by 8 h, the rd mice in the PBS control group took 4.67 ± 0.79 days to complete the synchronization with the shifted cycle, while those in the 100 ng/μl and 200 ng/μl groups required 7.90 ± 0.55 days and 11.00 ± 0.79 days to complete the synchronization with the new light/dark cycle, respectively.Conclusion. Our study indicates that the regulation of some NIF visual functions is dependent on a certain minimal number of intact functional ipRGCs.

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