scholarly journals Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits

2016 ◽  
Vol 308 ◽  
pp. 222-235 ◽  
Author(s):  
Kaitlin H. Snider ◽  
Heather Dziema ◽  
Sydney Aten ◽  
Jacob Loeser ◽  
Frances E. Norona ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Learning And Memory ◽  
Clock Gene ◽  
Circadian Clock Gene ◽  
Targeted Deletion

scholarly journals Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function

2020 ◽  
Vol 21 (4) ◽  
pp. 1394
Author(s):  
Amira A. H. Ali ◽  
Federica Tundo-Lavalle ◽  
Soha A. Hassan ◽  
Martina Pfeffer ◽  
Anna Stahr ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Olfactory Bulb ◽  
Circadian Clock ◽  
Adult Neurogenesis ◽  
Clock Gene ◽  
Olfactory Function ◽  
Circadian Clock Gene ◽  
Targeted Deletion ◽  
Forebrain Neurons ◽  
And Behavior

The circadian system is an endogenous timekeeping system that synchronizes physiology and behavior with the 24 h solar day. Mice with total deletion of the core circadian clock gene Bmal1 show circadian arrhythmicity, cognitive deficits, and accelerated age-dependent decline in adult neurogenesis as a consequence of increased oxidative stress. However, it is not yet known if the impaired adult neurogenesis is due to circadian disruption or to loss of the Bmal1 gene function. Therefore, we investigated oxidative stress and adult neurogenesis of the two principle neurogenic niches, the hippocampal subgranular zone and the subventricular zone in mice with a forebrain specific deletion of Bmal1 (Bmal1 fKO), which show regular circadian rhythmicity. Moreover, we analyzed the morphology of the olfactory bulb, as well as olfactory function in Bmal1 fKO mice. In Bmal1 fKO mice, oxidative stress was increased in subregions of the hippocampus and the olfactory bulb but not in the neurogenic niches. Consistently, adult neurogenesis was not affected in Bmal1 fKO mice. Although Reelin expression in the olfactory bulb was higher in Bmal1 fKO mice as compared to wildtype mice (Bmal1 WT), the olfactory function was not affected. Taken together, the targeted deletion of Bmal1 in mouse forebrain neurons is associated with a regional increase in oxidative stress and increased Reelin expression in the olfactory bulb but does not affect adult neurogenesis or olfactory function.

scholarly journals Effect of Circadian Clock Gene Mutations on Nonvisual Photoreception in the Mouse

2012 ◽  
Vol 53 (1) ◽  
pp. 454 ◽  
Author(s):  
Leah Owens ◽  
Ethan Buhr ◽  
Daniel C. Tu ◽  
Tamara L. Lamprecht ◽  
Janet Lee ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Clock Gene ◽  
Gene Mutations ◽  
Circadian Clock Gene
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