Dizocilpine (MK-801) impairs learning in the active place avoidance task but has no effect on the performance during task/context alternation

2016 ◽  
Vol 305 ◽  
pp. 247-257 ◽  
Author(s):  
Iveta Vojtechova ◽  
Tomas Petrasek ◽  
Hana Hatalova ◽  
Adela Pistikova ◽  
Karel Vales ◽  
...  
Keyword(s):  
Avoidance Task ◽  
Task Context ◽  
Mk 801 ◽  
Place Avoidance

scholarly journals Higher Doses of (+)MK-801 (Dizocilpine) Induced Mortality and Procedural but Not Cognitive Deficits in Delayed Testing in the Active Place Avoidance With Reversal on the Carousel

2015 ◽  
pp. 269-275
Author(s):  
E. BRICHTOVÁ ◽  
T. PETRÁSEK ◽  
K. VALEŠ ◽  
A. STUCHLÍK
Keyword(s):  
Cognitive Deficits ◽  
High Dose ◽  
Avoidance Task ◽  
Breeding Colony ◽  
Mk 801 ◽  
Place Avoidance ◽  
Long Evans ◽  
Higher Doses ◽  
Systemic Application ◽  
Significant Mortality

Schizophrenia is a devastating disorder affecting 1 % of the world's population. An important role in the study of this disease is played by animal models. Since there is evidence that acute psychotic episodes can have consequences on later cognitive functioning, the present study has investigated the effects of a single systemic application of higher doses of (+)MK-801 (3 mg/kg and 5 mg/kg) to adult male Long-Evans rats from the Institute’s breeding colony on delayed testing in the active place avoidance task with reversal on the Carousel (a rotating arena). Besides significant mortality due to the injections, a disruption of procedural functions in active place avoidance, after the dose 5 mg/kg was observed. It was concluded that Long-Evans rats from our breeding colony do not represent a suitable biomodel for studying the effects of single high-dose NMDA antagonists.

scholarly journals Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task

2008 ◽  
Vol 105 (3) ◽  
pp. 1061-1066 ◽  
Author(s):  
V. Bubenikova-Valesova ◽  
A. Stuchlik ◽  
J. Svoboda ◽  
J. Bures ◽  
K. Vales
Keyword(s):  
Avoidance Task ◽  
Place Avoidance ◽  
Block Effect

scholarly journals Silver Nanoparticles Impair Cognitive Functions and Modify the Hippocampal Level of Neurotransmitters in a Coating-Dependent Manner

2021 ◽  
Vol 22 (23) ◽  
pp. 12706
Author(s):  
Katarzyna Dziendzikowska ◽  
Małgorzata Węsierska ◽  
Joanna Gromadzka-Ostrowska ◽  
Jacek Wilczak ◽  
Michał Oczkowski ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Spatial Memory ◽  
Antibacterial Properties ◽  
Coating Material ◽  
Long Term Memory ◽  
Avoidance Task ◽  
Dependent Manner ◽  
Memory Functioning ◽  
Place Avoidance ◽  
The Brain

Due to their potent antibacterial properties, silver nanoparticles (AgNPs) are widely used in industry and medicine. However, they can cross the brain–blood barrier, posing a risk to the brain and its functions. In our previous study, we demonstrated that oral administration of bovine serum albumin (BSA)-coated AgNPs caused an impairment in spatial memory in a dose-independent manner. In this study, we evaluated the effects of AgNPs coating material on cognition, spatial memory functioning, and neurotransmitter levels in rat hippocampus. AgNPs coated with BSA (AgNPs(BSA)), polyethylene glycol (AgNPs(PEG)), or citrate (AgNPs(Cit)) or silver ions (Ag+) were orally administered at a dose of 0.5 mg/kg b.w. to male Wistar rats for a period of 28 days, while the control (Ctrl) rats received 0.2 mL of water. The acquisition and maintenance of spatial memory related to place avoidance were assessed using the active allothetic place avoidance task, in which rats from AgNPs(BSA), AgNPs(PEG), and Ag+ groups performed worse than the Ctrl rats. In the retrieval test assessing long-term memory, only rats from AgNPs(Cit) and Ctrl groups showed memory maintenance. The analysis of neurotransmitter levels indicated that the ratio between serotonin and dopamine concentration was disturbed in the AgNPs(BSA) rats. Furthermore, treatment with AgNPs or Ag+ resulted in the induction of peripheral inflammation, which was reflected by the alterations in the levels of serum inflammatory mediators. In conclusion, depending on the coating material used for their stabilization, AgNPs induced changes in memory functioning and concentration of neurotransmitters.

Modeling of Selection of Relevant Cues in Rats: Effects of Task Complexity and Lesions of Medial Prefrontal Cortex

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Svoboda ◽  
K. Blahna ◽  
P. Telensky ◽  
J. Bures ◽  
A. Stuchlik
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Cognitive Processing ◽  
Task Complexity ◽  
Vestibular Stimulation ◽  
Psychiatric Research ◽  
Avoidance Task ◽  
Future Directions ◽  
Place Avoidance ◽  
Selection Of

One of key features of cognitive processing in both humans and animals is to select relevant stimuli. Several rodent spatial paradigms proved to be useful in biological psychiatric research. A place avoidance task has been previously used in animal model of cognitive deficits in psychosis.Here we present modifications of the place avoidance paradigm, assessing the ability of selecting appropriate cues at various levels of task complexity. Moreover, we present a pilot experiment showing an effect of lesion to medial prefrontal cortex (mPFC) on those tasks. Generally, the place avoidance apparatus consists of a circular arena elevated 1m above the floor. Rats are trained to avoid an unmarked forbidden sector, entering which is punished by mild footshocks. The sector can be defined with respect to the room or arena frame, which can be dissociated by arena rotation. Moreover, we studied an ability of rats to avoid the place defined by salient rotating object.The results showed that animals with mPFC lesion were capable of avoiding a place defined either by distal of by proximal cues, similarly as controls. However, both control and mPFC-lesioned rats had difficulties to avoid a place surrounding moving salient object. The performance increased whenever the rat was passively rotated with the arena, suggesting that vestibular stimulation enhanced the directed attention to an object. The poster will discuss the present findings and outline the future directions with emphasis on their utilization in animal models of neuropsychiatric disorders.Supported by GACR grants 309/07/0341 and 309/06/1231.

Can rats solve the active place avoidance task without the room-bound cues?

2014 ◽  
Vol 267 ◽  
pp. 126-132 ◽  
Author(s):  
Iveta Fajnerova ◽  
Jana Kenney ◽  
Veronika Lobellova ◽  
Sarka Okrouhlicova ◽  
Ales Stuchlik ◽  
...  
Keyword(s):  
Avoidance Task ◽  
Place Avoidance

Traumatic brain injury enhances the amnesic effect of an NMDA antagonist in rats

1994 ◽  
Vol 81 (2) ◽  
pp. 267-271 ◽  
Author(s):  
Robert J. Hamm ◽  
Brian R. Pike ◽  
Dianne M. O'Dell ◽  
Bruce G. Lyeth
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Passive Avoidance ◽  
Nmda Antagonist ◽  
Saline Group ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
Mk 801 ◽  
Avoidance Testing ◽  
Enhanced Sensitivity

✓ The authors have examined the effect of experimental traumatic brain injury on the amnesia produced by the N-methyl-D-aspartate (NMDA) antagonist MK-801. Rats were either subjected to a moderate level of fluid-percussion injury or prepared for injury but not injured (“sham injury”). Nine days following injury or sham injury, the rats were injected either with saline (sham/saline group, nine rats; injured/saline group, nine rats) or with 0.1 mg/kg of MK-801 (sham/MK-801 group, nine rats; injured/MK-801 group, eight rats) 30 minutes before being trained on a passive-avoidance task. Twenty-four hours later, the rats were tested for retention of the passive-avoidance task. Results revealed that the low dose of MK-801 did not significantly affect retention of the passive-avoidance task in the sham-injured group. In injured animals, administration of MK-801 produced a profound amnesia in contrast to the sham-injured animals treated with MK-801 and the injured animals treated with saline. To further investigate this enhanced sensitivity to the amnesic effects of MK-801 exhibited by the injured animals, nine injured and eight sham-injured rats were injected with 0.3 mg/kg of MK-801 15 minutes before injury. Results indicated that the animals treated with MK-801 before injury did not significantly differ from the sham-injured animals in retention of the passive-avoidance task. In addition, test results in the animals treated with MK-801 before injury and reinjected with MK-801 before passive-avoidance testing did not differ from those in untreated injured animals reinjected with saline before passive-avoidance testing. These findings indicate that MK-801 treatment before injury prevented the enhanced sensitivity to MK-801-induced amnesia that follows traumatic brain injury.

scholarly journals Analysis of behaviour in the Active Allothetic Place Avoidance task based on cluster analysis of the rat movement motifs

2017 ◽  
Author(s):  
Tiago V. Gehring ◽  
Malgorzata J. Wesierska ◽  
Daniel K. Wójcik ◽  
Eleni Vasilaki
Keyword(s):  
Cluster Analysis ◽  
Performance Measures ◽  
Clustering Algorithm ◽  
Memory Performance ◽  
Reference Memory ◽  
Individual Performance ◽  
Avoidance Task ◽  
Standard Analysis ◽  
Place Avoidance ◽  
Freely Moving

AbstractThe Active Allothetic Place Avoidance test (AAPA) is a useful tool to study spatial memory in a dynamic world. In this task a rat, freely moving on a rotating circular arena, has to avoid a sector where shocks are presented. The standard analysis of memory performance in the AAPA task relies on evaluating individual performance measures. Here we present a new method of analysis for the AAPA test that focuses on the movement paths of the animals and utilizes a clustering algorithm to automatically extract the stereotypical types of behaviour as reflected in the recorded paths. We apply the method to experiments that study the effect of silver nanoparticles (AgNPs) on the reference memory and identify six major classes of movement motifs not previously described in AAPA tests. The method allows us to analyse the data with no prior expectations about the motion to be seen in the experiments.

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