Baclofen dose-dependently disrupts learning in a place avoidance task requiring cognitive coordination

2009 ◽  
Vol 97 (3-4) ◽  
pp. 507-511 ◽  
Author(s):  
Ales Stuchlik ◽  
Karel Vales
Keyword(s):  
Avoidance Task ◽  
Place Avoidance

scholarly journals Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task

2008 ◽  
Vol 105 (3) ◽  
pp. 1061-1066 ◽  
Author(s):  
V. Bubenikova-Valesova ◽  
A. Stuchlik ◽  
J. Svoboda ◽  
J. Bures ◽  
K. Vales
Keyword(s):  
Avoidance Task ◽  
Place Avoidance ◽  
Block Effect

scholarly journals Silver Nanoparticles Impair Cognitive Functions and Modify the Hippocampal Level of Neurotransmitters in a Coating-Dependent Manner

2021 ◽  
Vol 22 (23) ◽  
pp. 12706
Author(s):  
Katarzyna Dziendzikowska ◽  
Małgorzata Węsierska ◽  
Joanna Gromadzka-Ostrowska ◽  
Jacek Wilczak ◽  
Michał Oczkowski ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Spatial Memory ◽  
Antibacterial Properties ◽  
Coating Material ◽  
Long Term Memory ◽  
Avoidance Task ◽  
Dependent Manner ◽  
Memory Functioning ◽  
Place Avoidance ◽  
The Brain

Due to their potent antibacterial properties, silver nanoparticles (AgNPs) are widely used in industry and medicine. However, they can cross the brain–blood barrier, posing a risk to the brain and its functions. In our previous study, we demonstrated that oral administration of bovine serum albumin (BSA)-coated AgNPs caused an impairment in spatial memory in a dose-independent manner. In this study, we evaluated the effects of AgNPs coating material on cognition, spatial memory functioning, and neurotransmitter levels in rat hippocampus. AgNPs coated with BSA (AgNPs(BSA)), polyethylene glycol (AgNPs(PEG)), or citrate (AgNPs(Cit)) or silver ions (Ag+) were orally administered at a dose of 0.5 mg/kg b.w. to male Wistar rats for a period of 28 days, while the control (Ctrl) rats received 0.2 mL of water. The acquisition and maintenance of spatial memory related to place avoidance were assessed using the active allothetic place avoidance task, in which rats from AgNPs(BSA), AgNPs(PEG), and Ag+ groups performed worse than the Ctrl rats. In the retrieval test assessing long-term memory, only rats from AgNPs(Cit) and Ctrl groups showed memory maintenance. The analysis of neurotransmitter levels indicated that the ratio between serotonin and dopamine concentration was disturbed in the AgNPs(BSA) rats. Furthermore, treatment with AgNPs or Ag+ resulted in the induction of peripheral inflammation, which was reflected by the alterations in the levels of serum inflammatory mediators. In conclusion, depending on the coating material used for their stabilization, AgNPs induced changes in memory functioning and concentration of neurotransmitters.

Modeling of Selection of Relevant Cues in Rats: Effects of Task Complexity and Lesions of Medial Prefrontal Cortex

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Svoboda ◽  
K. Blahna ◽  
P. Telensky ◽  
J. Bures ◽  
A. Stuchlik
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Cognitive Processing ◽  
Task Complexity ◽  
Vestibular Stimulation ◽  
Psychiatric Research ◽  
Avoidance Task ◽  
Future Directions ◽  
Place Avoidance ◽  
Selection Of

One of key features of cognitive processing in both humans and animals is to select relevant stimuli. Several rodent spatial paradigms proved to be useful in biological psychiatric research. A place avoidance task has been previously used in animal model of cognitive deficits in psychosis.Here we present modifications of the place avoidance paradigm, assessing the ability of selecting appropriate cues at various levels of task complexity. Moreover, we present a pilot experiment showing an effect of lesion to medial prefrontal cortex (mPFC) on those tasks. Generally, the place avoidance apparatus consists of a circular arena elevated 1m above the floor. Rats are trained to avoid an unmarked forbidden sector, entering which is punished by mild footshocks. The sector can be defined with respect to the room or arena frame, which can be dissociated by arena rotation. Moreover, we studied an ability of rats to avoid the place defined by salient rotating object.The results showed that animals with mPFC lesion were capable of avoiding a place defined either by distal of by proximal cues, similarly as controls. However, both control and mPFC-lesioned rats had difficulties to avoid a place surrounding moving salient object. The performance increased whenever the rat was passively rotated with the arena, suggesting that vestibular stimulation enhanced the directed attention to an object. The poster will discuss the present findings and outline the future directions with emphasis on their utilization in animal models of neuropsychiatric disorders.Supported by GACR grants 309/07/0341 and 309/06/1231.

Can rats solve the active place avoidance task without the room-bound cues?

2014 ◽  
Vol 267 ◽  
pp. 126-132 ◽  
Author(s):  
Iveta Fajnerova ◽  
Jana Kenney ◽  
Veronika Lobellova ◽  
Sarka Okrouhlicova ◽  
Ales Stuchlik ◽  
...  
Keyword(s):  
Avoidance Task ◽  
Place Avoidance

scholarly journals Analysis of behaviour in the Active Allothetic Place Avoidance task based on cluster analysis of the rat movement motifs

2017 ◽  
Author(s):  
Tiago V. Gehring ◽  
Malgorzata J. Wesierska ◽  
Daniel K. Wójcik ◽  
Eleni Vasilaki
Keyword(s):  
Cluster Analysis ◽  
Performance Measures ◽  
Clustering Algorithm ◽  
Memory Performance ◽  
Reference Memory ◽  
Individual Performance ◽  
Avoidance Task ◽  
Standard Analysis ◽  
Place Avoidance ◽  
Freely Moving

AbstractThe Active Allothetic Place Avoidance test (AAPA) is a useful tool to study spatial memory in a dynamic world. In this task a rat, freely moving on a rotating circular arena, has to avoid a sector where shocks are presented. The standard analysis of memory performance in the AAPA task relies on evaluating individual performance measures. Here we present a new method of analysis for the AAPA test that focuses on the movement paths of the animals and utilizes a clustering algorithm to automatically extract the stereotypical types of behaviour as reflected in the recorded paths. We apply the method to experiments that study the effect of silver nanoparticles (AgNPs) on the reference memory and identify six major classes of movement motifs not previously described in AAPA tests. The method allows us to analyse the data with no prior expectations about the motion to be seen in the experiments.

scholarly journals Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Harrison Tudor Evans ◽  
Liviu-Gabriel Bodea ◽  
Jürgen Götz
Keyword(s):  
Amino Acid ◽  
Hippocampal Neurons ◽  
De Novo ◽  
Trna Synthetase ◽  
Memory Formation ◽  
Long Term Memory ◽  
Avoidance Task ◽  
Canonical Amino Acid ◽  
Cell Type Specific ◽  
Place Avoidance

The formation of spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this process is lacking. Here, we generated a novel mouse strain, which enables cell-type-specific labelling of newly synthesised proteins with non-canonical amino acids (NCAAs) by genetically restricting the expression of the mutant tRNA synthetase, NLL-MetRS, to hippocampal neurons. By combining this labelling technique with an accelerated version of the active place avoidance task and bio-orthogonal non-canonical amino acid tagging (BONCAT) followed by SWATH quantitative mass spectrometry, we identified 156 proteins that were altered in synthesis in hippocampal neurons during spatial memory formation. In addition to observing increased synthesis of known proteins important in memory-related processes, such as glutamate receptor recycling, we also identified altered synthesis of proteins associated with mRNA splicing as a potential mechanism involved in spatial LTM formation.

scholarly journals Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1

2017 ◽  
Author(s):  
Dino Dvorak ◽  
Basma Radwan ◽  
Fraser T. Sparks ◽  
Zoe Nicole Talbot ◽  
André A. Fenton
Keyword(s):  
Fragile X Syndrome ◽  
Cognitive Deficits ◽  
Pyramidal Cell ◽  
Fragile X ◽  
Avoidance Task ◽  
Cognitive Variables ◽  
Wild Type ◽  
Cognitive Inflexibility ◽  
Place Avoidance ◽  
Shock Zone

ABSTRACTBehavior is used to assess memory and cognitive deficits in animals like Fmrl-null mice that model Fragile X Syndrome, but behavior is a proxy for unknown neural events that define cognitive variables like recollection. We identified an electrophysiological signature of recollection in mouse dorsal CA1 hippocampus. During a shocked-place avoidance task, slow gamma (SG: 30-50 Hz) dominates mid-frequency gamma (MG: 70-90 Hz) oscillations 2-3 seconds before successful avoidance, but not failures. Wild-type but not Fmrl-null mice rapidly adapt to relocating the shock; concurrently, SG/MG maxima (SGdominance) decrease in wild-type but not in cognitively inflexible Fmrl-null mice. During SGdominance, putative pyramidal cell ensembles represent distant locations; during place avoidance, these are avoided places. During shock relocation, wild-type ensembles represent distant locations near the currently-correct shock zone but Fmrl-null ensembles represent the formerly-correct zone. These findings indicate that recollection occurs when CA1 slow gamma dominates mid-frequency gamma, and that accurate recollection of inappropriate memories explains Fmrl-null cognitive inflexibility.

scholarly journals Higher Doses of (+)MK-801 (Dizocilpine) Induced Mortality and Procedural but Not Cognitive Deficits in Delayed Testing in the Active Place Avoidance With Reversal on the Carousel

2015 ◽  
pp. 269-275
Author(s):  
E. BRICHTOVÁ ◽  
T. PETRÁSEK ◽  
K. VALEŠ ◽  
A. STUCHLÍK
Keyword(s):  
Cognitive Deficits ◽  
High Dose ◽  
Avoidance Task ◽  
Breeding Colony ◽  
Mk 801 ◽  
Place Avoidance ◽  
Long Evans ◽  
Higher Doses ◽  
Systemic Application ◽  
Significant Mortality

Schizophrenia is a devastating disorder affecting 1 % of the world's population. An important role in the study of this disease is played by animal models. Since there is evidence that acute psychotic episodes can have consequences on later cognitive functioning, the present study has investigated the effects of a single systemic application of higher doses of (+)MK-801 (3 mg/kg and 5 mg/kg) to adult male Long-Evans rats from the Institute’s breeding colony on delayed testing in the active place avoidance task with reversal on the Carousel (a rotating arena). Besides significant mortality due to the injections, a disruption of procedural functions in active place avoidance, after the dose 5 mg/kg was observed. It was concluded that Long-Evans rats from our breeding colony do not represent a suitable biomodel for studying the effects of single high-dose NMDA antagonists.

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