scholarly journals Examining the role of dopamine D2 and D3 receptors in Pavlovian conditioned approach behaviors

2016 ◽  
Vol 305 ◽  
pp. 87-99 ◽  
Author(s):  
Kurt M. Fraser ◽  
Joshua L. Haight ◽  
Eliot L. Gardner ◽  
Shelly B. Flagel
Keyword(s):  
D3 Receptors ◽  
Dopamine D2 ◽  
Pavlovian Conditioned Approach ◽  
Approach Behaviors ◽  
Conditioned Approach

scholarly journals Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons

2017 ◽  
Vol 55 (2) ◽  
pp. 1054-1067 ◽  
Author(s):  
Federica Bono ◽  
Paola Savoia ◽  
Adele Guglielmi ◽  
Massimo Gennarelli ◽  
Giovanna Piovani ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
D3 Receptors ◽  
Dopamine D2 ◽  
Midbrain Dopaminergic Neurons ◽  
Human Ipsc

scholarly journals Adrenergic manipulation inhibits pavlovian conditioned approach behaviors

2018 ◽  
Vol 339 ◽  
pp. 278-285 ◽  
Author(s):  
Kyle Z. Pasquariello ◽  
Marina Han ◽  
Cagla Unal ◽  
Paul J. Meyer
Keyword(s):  
Pavlovian Conditioned Approach ◽  
Approach Behaviors ◽  
Conditioned Approach

scholarly journals The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues

2020 ◽  
Author(s):  
Joshua L Haight ◽  
Paolo Campus ◽  
Cristina E Maria-Rios ◽  
Allison M Johnson ◽  
Marin S Klumpner ◽  
...  
Keyword(s):  
Conditioned Response ◽  
Male Rats ◽  
Incentive Salience ◽  
Sprague Dawley ◽  
Conditioned Reward ◽  
Hypothalamic Area ◽  
Sign Tracking ◽  
Pavlovian Conditioned Approach ◽  
Conditioned Approach

AbstractRationalePrior research suggests that inputs from the lateral hypothalamic area (LHA) to the paraventricular nucleus of the thalamus (PVT) contribute to the attribution of incentive salience to Pavlovian-conditioned reward cues. However, a causal role for the LHA in this phenomenon has not been demonstrated. In addition, it is unknown which hypothalamic neurotransmitter or peptide system(s) are involved in mediating incentive salience attribution.ObjectivesTo examine: 1) the role of the LHA in the propensity to attribute incentive salience to reward cues, and 2) the role of orexinergic signaling in the PVT on the expression of Pavlovian conditioned approach (PavCA) behavior, a reflection of incentive salience attribution.MethodsMale Sprague-Dawley rats received bilateral excitotoxic lesions of the LHA prior to the acquisition of Pavlovian conditioned approach (PavCA) behavior. A separate cohort of male rats acquired PavCA behavior and were characterized as sign-trackers (STs) or goal-trackers (GTs) based on their conditioned response. The orexin 1 receptor (OX1r) antagonist SB-334867, or the orexin 2 receptor (OX2r) antagonist TCS-OX2-29, were then administered directly into the PVT to assess the effects of these pharmacological agents on the expression of PavCA behavior and on the conditioned reinforcing properties of the Pavlovian reward cue.ResultsLesions of the LHA before training attenuated the development of lever-directed (sign-tracking) behaviors in the PavCA paradigm, without affecting magazine-directed (goal-tracking) behaviors. In STs, administration of the OX1r antagonist into the PVT reduced lever-directed behaviors and increased magazine-directed behaviors; while administration of the OX2r antagonist only reduced lever-directed behaviors. Further, OX2r, but not OX1r, antagonism was able to reduce the incentive motivational value of the conditioned stimulus on a conditioned reinforcement test in STs. The behavior of GTs was unaffected by orexinergic antagonism in the PVT.ConclusionsThe LHA is necessary for the attribution of incentive salience to reward cues and, thereby, the development of a sign-tracking conditioned response. Furthermore, blockade of orexin signaling in the PVT attenuates the incentive value of a Pavlovian reward cue. These data suggest that hypothalamic orexin inputs to the PVT are a key component of the circuitry that encodes the incentive motivational value of reward cues and promotes maladaptive cue-driven behaviors.

scholarly journals Sleep Deprivation Decreases Binding of [11C]Raclopride to Dopamine D2/D3 Receptors in the Human Brain

2008 ◽  
Vol 28 (34) ◽  
pp. 8454-8461 ◽  
Author(s):  
N. D. Volkow ◽  
G.-J. Wang ◽  
F. Telang ◽  
J. S. Fowler ◽  
J. Logan ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Human Brain ◽  
D3 Receptors ◽  
Dopamine D2

Specific [3H]raclopride binding to neostriatal dopamine D2 receptors: Role of disulfide and sulfhydryl groups

1992 ◽  
Vol 17 (8) ◽  
pp. 749-759 ◽  
Author(s):  
Tomás A. Reader ◽  
Eduardo Molina-Holgado ◽  
Lucimey Lima ◽  
Sylvie Boulianne ◽  
Karen M. Dewar
Keyword(s):  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Sulfhydryl Groups ◽  
Dopamine D2

Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome

2003 ◽  
Vol 117B (1) ◽  
pp. 57-60 ◽  
Author(s):  
Kazuo Mihara ◽  
Tsuyoshi Kondo ◽  
Akihito Suzuki ◽  
Norio Yasui-Furukori ◽  
Shingo Ono ◽  
...  
Keyword(s):  
Neuroleptic Malignant Syndrome ◽  
Gene Polymorphisms ◽  
D3 Receptors ◽  
Dopamine D2
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