Memory formation and retention are affected in adult miR-132/212 knockout mice

2015 ◽  
Vol 287 ◽  
pp. 15-26 ◽  
Author(s):  
Julia Hernandez-Rapp ◽  
Pascal Y. Smith ◽  
Mohammed Filali ◽  
Claudia Goupil ◽  
Emmanuel Planel ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Memory Formation

scholarly journals GluA4 enables associative memory formation by facilitating cerebellar expansion coding

2020 ◽  
Author(s):  
Katarzyna Kita ◽  
Catarina Albergaria ◽  
Ana S. Machado ◽  
Megan R. Carey ◽  
Martin Müller ◽  
...  
Keyword(s):  
Associative Learning ◽  
Associative Memory ◽  
Granule Cell ◽  
Ampa Receptors ◽  
Knockout Mice ◽  
Mossy Fiber ◽  
Eyeblink Conditioning ◽  
Memory Formation ◽  
Synaptic Excitation ◽  
Excitatory Neurotransmission

AbstractAMPA receptors (AMPARs) mediate excitatory neurotransmission in the CNS and their subunit composition determines synaptic efficacy. Whereas AMPAR subunits GluA1–GluA3 have been linked to particular forms of synaptic plasticity and learning, the functional role of GluA4 remains elusive. Here we used electrophysiological, computational and behavioral approaches to demonstrate a crucial function of GluA4 for synaptic excitation and associative memory formation in the cerebellum. Notably, GluA4-knockout mice had ∼80% reduced mossy fiber to granule cell synaptic transmission. The fidelity of granule cell spike output was markedly decreased despite attenuated tonic inhibition and increased NMDA receptor-mediated transmission. Computational modeling revealed that GluA4 facilitates pattern separation that is important for associative learning. On a behavioral level, while locomotor coordination was generally spared, GluA4-knockout mice failed to form associative memories during delay eyeblink conditioning. These results demonstrate an essential role for GluA4-containing AMPARs in cerebellar information processing and associative learning.

scholarly journals GluA4 facilitates cerebellar expansion coding and enables associative memory formation

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Katarzyna Kita ◽  
Catarina Albergaria ◽  
Ana S Machado ◽  
Megan R Carey ◽  
Martin Mueller ◽  
...  
Keyword(s):  
Associative Learning ◽  
Associative Memory ◽  
Granule Cell ◽  
Ampa Receptors ◽  
Knockout Mice ◽  
Mossy Fiber ◽  
Eyeblink Conditioning ◽  
Memory Formation ◽  
Synaptic Excitation ◽  
Excitatory Neurotransmission

AMPA receptors (AMPARs) mediate excitatory neurotransmission in the CNS and their subunit composition determines synaptic efficacy. Whereas AMPAR subunits GluA1–GluA3 have been linked to particular forms of synaptic plasticity and learning, the functional role of GluA4 remains elusive. Here we demonstrate a crucial function of GluA4 for synaptic excitation and associative memory formation in the cerebellum. Notably, GluA4-knockout mice had ~80% reduced mossy fiber to granule cell synaptic transmission. The fidelity of granule cell spike output was markedly decreased despite attenuated tonic inhibition and increased NMDA receptor-mediated transmission. Computational network modeling incorporating these changes revealed that deletion of GluA4 impairs granule cell expansion coding, which is important for pattern separation and associative learning. On a behavioral level, while locomotor coordination was generally spared, GluA4-knockout mice failed to form associative memories during delay eyeblink conditioning. These results demonstrate an essential role for GluA4-containing AMPARs in cerebellar information processing and associative learning.

scholarly journals Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice

2019 ◽  
Vol 65 (3) ◽  
pp. 209-216
Author(s):  
Kazuki Kurihara ◽  
Takujiro Homma ◽  
Sho Kobayashi ◽  
Mototada Shichiri ◽  
Hiroki Fujiwara ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Spatial Memory ◽  
Knockout Mice ◽  
Memory Formation

scholarly journals New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning

2009 ◽  
Vol 16 (7) ◽  
pp. 439-451 ◽  
Author(s):  
P. Jaholkowski ◽  
A. Kiryk ◽  
P. Jedynak ◽  
N. M. Ben Abdallah ◽  
E. Knapska ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Hippocampal Neurons ◽  
Memory Formation ◽  
Adult Brain ◽  
Cyclin D2

Heat stable toxin of E. coli (STa) stimulates duodenal mucosal bicarbonate secretion in cystic fibrosis knockout mice

2001 ◽  
Vol 120 (5) ◽  
pp. A137-A137
Author(s):  
D CHILDS ◽  
D CROMBIE ◽  
V PRATHA ◽  
Z SELLERS ◽  
D HOGAN ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Knockout Mice ◽  
Bicarbonate Secretion ◽  
E Coli ◽  
Heat Stable

Sa1495 LEPTIN AUGMENTS BILIARY HYPERPLASIA AND HEPATIC FIBROSIS IN MDR2-KNOCKOUT MICE

2020 ◽  
Vol 158 (6) ◽  
pp. S-1310
Author(s):  
Rebekah John ◽  
Anca D. Petrescu ◽  
Stephanie Grant ◽  
Elaina Williams ◽  
Sharon DeMorrow
Keyword(s):  
Hepatic Fibrosis ◽  
Knockout Mice

Abstract #219: Evidence of Insulitis in Signal Transducer and Activator of Transcription 5 (Stat5) Knockout Mice

2017 ◽  
Vol 23 ◽  
pp. 39
Author(s):  
Aili Guo ◽  
Nigel Daniels ◽  
Craig Nunemaker ◽  
Samantha J. Shaw ◽  
Karen Coschigano
Keyword(s):  
Knockout Mice ◽  
Signal Transducer

Xpa and Xpa/p53 +/- Knockout Mice: Overview of Available Data

2001 ◽  
Vol 29 (5) ◽  
pp. 117-127 ◽  
Author(s):  
Coen F. van Kreijl ◽  
Peter A. McAnulty ◽  
Rudolf B. Beems ◽  
An Vynckier ◽  
Harry van Steeg ◽  
...  
Keyword(s):  
Knockout Mice
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