The protective effect of hyperbaric oxygen and Ginkgo biloba extract on A?25?35-induced oxidative stress and neuronal apoptosis in rats

2013 ◽  
Vol 242 ◽  
pp. 1-8 ◽  
Author(s):  
XiaoQiang Tian ◽  
LiDa Zhang ◽  
JingMei Wang ◽  
JianGuo Dai ◽  
ShanShan Shen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Hyperbaric Oxygen ◽  
Ginkgo Biloba ◽  
Neuronal Apoptosis ◽  
Ginkgo Biloba Extract

scholarly journals Ginkgo biloba extract protects human melanocytes from H 2 O 2 ‐induced oxidative stress by activating Nrf2

2019 ◽  
Vol 23 (8) ◽  
pp. 5193-5199 ◽  
Author(s):  
Shaolong Zhang ◽  
Xiuli Yi ◽  
Xin Su ◽  
Zhe Jian ◽  
Tingting Cui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Human Melanocytes

Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: Role of oxidative stress

2011 ◽  
Vol 59 (5) ◽  
pp. 628-636 ◽  
Author(s):  
Patricia Rojas ◽  
Norma Serrano-García ◽  
Omar N. Medina-Campos ◽  
José Pedraza-Chaverri ◽  
Sven O. Ögren ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ginkgo Biloba ◽  
Forced Swimming Test ◽  
Ginkgo Biloba Extract ◽  
Forced Swimming ◽  
Swimming Test

scholarly journals Age-related increase of oxidative stress-induced apoptosis in micePrevention by Ginkgo biloba extract (EGb761)

2001 ◽  
Vol 108 (8) ◽  
pp. 969-978 ◽  
Author(s):  
K. Schindowski ◽  
S. Leutner ◽  
S. Kressmann ◽  
A. Eckert ◽  
W. E. Müller
Keyword(s):  
Oxidative Stress ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Age Related ◽  
Induced Apoptosis ◽  
Related Increase

scholarly journals Mitochondrial effects of Ginkgo biloba extract

2012 ◽  
Vol 24 (S1) ◽  
pp. S18-S20 ◽  
Author(s):  
Anne Eckert
Keyword(s):  
Oxidative Stress ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Mitochondrial Enzymes ◽  
Protective Effects ◽  
Protective Capacity ◽  
Slowing Down ◽  
Median Lifespan ◽  
Regulatory Effects ◽  
Induced Defects

ABSTRACTOxidative stress and mitochondrial failure promote altered protein degradation, reduced neurotransmission, synapse loss and tau/hyperphosphorylation, which are early stages in the development of Alzheimer's disease (AD). A growing volume of data confirms that Ginkgo biloba extract (GBE) reduces oxidative stress and improves mitochondrial respiration and thus may be useful in preventing or slowing down the progression of AD. Treatment of Caenorhabditis elegans with GBE- extract reduces oxidative stress and extends median lifespan compared with controls. Levels of reactive oxygen species, including the superoxide anion radical, were reduced in brains from GBE-treated mice compared with controls. In older mice, GBE resulted in a protective effect by increasing production of adenosine triphosphate in neurons. A respiratory experiment indicated that GBE was able to rescue Aβ-induced defects in energy metabolism, with results suggesting long-term regulatory effects on mitochondria. GBE also had a selective effect on the activities of mitochondrial enzymes that assemble the electron transport system. The flavonoids, bilobalide and some of the ginkgolides (B and J) had a high protective capacity, indicating that a combination of several compounds within standardized Gingko biloba extracts contribute disproportionately for these protective effects.

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