The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: Mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone

2011 ◽  
Vol 220 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Tomoko Horisawa ◽  
Tadashi Ishibashi ◽  
Hiroyuki Nishikawa ◽  
Takeshi Enomoto ◽  
Satoko Toma ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Learning And Memory ◽  
Morris Water Maze ◽  
Atypical Antipsychotic ◽  
Water Maze ◽  
The Novel ◽  
Mk 801 ◽  
Beneficial Effects ◽  
Selective Antagonists

scholarly journals Cognitive-Enhancing Effect ofAronia melanocarpaExtract against Memory Impairment Induced by Scopolamine in Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Hyeon Yong Lee ◽  
Jin Bae Weon ◽  
Youn Sik Jung ◽  
Nam Young Kim ◽  
Myong Ki Kim ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Learning And Memory ◽  
Morris Water Maze ◽  
Water Maze ◽  
Memory Impairment ◽  
Ache Activity ◽  
Antioxidant Effect ◽  
Enhancing Effect ◽  
Aronia Melanocarpa ◽  
Avoidance Tests

Aronia melanocarpa(A. melanocarpa)berriesare a fruit with a marked antioxidant effect. The objective of this study was to confirm the effect ofA. melanocarpa berriesextract against scopolamine-induced memory impairment in mice using the Morris water maze and passive avoidance test. Moreover, we determined a possible mechanism of the cognitive-enhancing effect involving AChE activity and BDNF and p-CREB expression in the hippocampus of mice.A. melanocarpa berriesextract attenuated the learning and memory impairment induced by scopolamine in the Morris water maze (79.3 ± 0.8 s of 200 mg/kg and 64.4 ± 10.7 s of 400 mg/kg on day 4) and passive avoidance tests (46.0 ± 41.1 s of 200 mg/kg and 25.6 ± 18.7 s of 400 mg/kg).A. melanocarpa berriesextract reduced the acetylcholinesterase level in the hippocampus of scopolamine-injected mice and increased BDNF and p-CREB expression in the hippocampus. The major compound, cyanidin-3-O-galactoside, also reversed memory impairment. These results showed thatA. melanocarpa berriesextract improved memory impairment by inhibiting AChE and increasing BDNF and p-CREB expression, and cyanidin-3-O-galactoside may be responsible for the effect ofA. melanocarpa berriesextract.

Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice

2011 ◽  
Vol 98 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Oguz Mutlu ◽  
Güner Ulak ◽  
Ipek Komsuoglu Celikyurt ◽  
Füruzan Yıldız Akar ◽  
Faruk Erden
Keyword(s):  
Learning And Memory ◽  
Morris Water Maze ◽  
Water Maze ◽  
Morris Water Maze Test ◽  
Mk 801 ◽  
Maze Test

Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats

2011 ◽  
Vol 99 (3) ◽  
pp. 316-323 ◽  
Author(s):  
Nejat Gacar ◽  
Oguz Mutlu ◽  
Tijen Utkan ◽  
Ipek Komsuoglu Celikyurt ◽  
Semil Selcen Gocmez ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Morris Water Maze ◽  
Water Maze ◽  
Memory Impairment ◽  
Beneficial Effects

Effects of Schisandra Polysaccharides on the Learning and Memory Ability in Brain Aging Mice

2014 ◽  
Vol 675-677 ◽  
pp. 1595-1599 ◽  
Author(s):  
Wei Jing Sun ◽  
Shu Jing ◽  
Chun Mei Wang ◽  
Cheng Yi Zhang ◽  
Hong Xia Sun ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Learning And Memory ◽  
Morris Water Maze ◽  
Water Maze ◽  
Brain Aging ◽  
Passive Avoidance Test ◽  
Morris Water Maze Test ◽  
Memory Ability ◽  
Avoidance Test ◽  
Mice Brain

This study focused on the improvement of Schisandra polysaccharide on the learning and memory in D-galactose-induced brain aging mice, to lay the foundation for the prevention and treatment of brain aging and related diseases. D-galactose was used to establish a mice brain aging model, Morris water maze and passive avoidance test were used to observe effects of Schisandra polysaccharide on the learning and memory ability of D- galactose-induced brain aging mice. The results showed that Schisandra polysaccharide could prolong the time of target qundrant, increase the number to cross the original platform in the Morris water maze test, and prolong the latency and reduce the number of errors of mice in the passive avoidance test. It is believed that Schisandra polysaccharide could improve the learning and memory ability of mice with brain aging.

Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats

2008 ◽  
Vol 186 (2) ◽  
pp. 197-207 ◽  
Author(s):  
T ENOMOTO ◽  
T ISHIBASHI ◽  
K TOKUDA ◽  
T ISHIYAMA ◽  
S TOMA ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Morris Water Maze ◽  
Water Maze ◽  
Radial Arm Maze ◽  
Mk 801

Protective effect of citicoline against aluminum-induced cognitive impairments in rats

2016 ◽  
Vol 33 (4) ◽  
pp. 308-317 ◽  
Author(s):  
Ahmed O Abdel-Zaher ◽  
Mostafa M Hamdy ◽  
Mahran S Abdel-Rahman ◽  
Doaa H Abd El-hamid
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Passive Avoidance ◽  
Morris Water Maze ◽  
Cognitive Deficits ◽  
Aluminum Chloride ◽  
Water Maze ◽  
Cognitive Impairments ◽  
Radial Arm Maze ◽  
Time Required

The potential protective effect of citicoline on aluminum chloride-induced cognitive deficits was investigated in rats. In a Morris water maze, administration of aluminum chloride to rats for 90 days resulted in increased escape latency to reach the platform and decreased swimming speed in acquisition trials. Similarly, in probe trials, the time required to reach the hidden platform was increased and the time spent in the target quadrant was reduced. Also, administration of aluminum chloride to rats for 90 days increased the reference and working memory errors and time required to end the task in the radial arm maze. In addition, this treatment decreased the step-through latency in the passive avoidance test. Concurrently, treatment of rats with aluminum chloride for 90 days increased hippocampal glutamate, malondialdehyde, and nitrite levels and decreased intracellular reduced glutathione level. In the citicoline-treated group, aluminum chloride-induced learning and memory impairments as assessed by the Morris water maze, radial arm maze, and passive avoidance tests were inhibited. At the same time, treatment of rats with citicoline prevented the biochemical alterations induced by aluminum chloride in the hippocampus. It can be concluded that elevation of hippocampal glutamate level with consequent oxidative stress and nitric oxide (NO) overproduction may play an important role in aluminum-induced cognitive impairments. Also, our results suggest, for the first time, that citicoline can protect against the development of these cognitive deficits through inhibition of aluminum-induced elevation of glutamate level, oxidative stress, and NO overproduction in the hippocampus.

The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze

2010 ◽  
Vol 33 (3) ◽  
pp. 463-468 ◽  
Author(s):  
Mahmoud Hosseini ◽  
Mosa Al-Reza Hadjzadeh ◽  
Mohammad Derakhshan ◽  
Shahrzad Havakhah ◽  
Fatemeh Behnam Rassouli ◽  
...  
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Memory Deficit ◽  
Adult Rats ◽  
Beneficial Effects
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