Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice

2006 ◽  
Vol 172 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Sophie Tambour ◽  
Vincent Didone ◽  
Ezio Tirelli ◽  
Etienne Quertemont
Keyword(s):  
Intraventricular Injections

Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit

1981 ◽  
Vol 240 (4) ◽  
pp. F329-F336 ◽  
Author(s):  
M. W. Bradbury ◽  
H. F. Cserr ◽  
R. J. Westrop
Keyword(s):  
Cerebrospinal Fluid ◽  
Caudate Nucleus ◽  
Subarachnoid Space ◽  
Interstitial Fluid ◽  
Bulk Flow ◽  
Perivascular Spaces ◽  
Csf Analysis ◽  
Intraventricular Injections ◽  
Intracerebral Microinjection ◽  
Do So

Lymph from the jugular lymph trunks of anesthetized rabbits has been continuously collected and radioiodinated albumin (RISA) therein estimated after microinjection of 1 microliter of 131I-albumin into the caudate nucleus, after single intraventricular injections, and during intraventricular infusions. Comparison of lymph at 7 and 25 h after intracerebral microinjection with efflux of radioactivity from whole brain suggests that about 50% of cleared radioactivity goes through lymph. Concentrations, normalized to cerebrospinal fluid (CSF), were much higher in lymph and retropharyngeal nodes after brain injection than after CSF injection or infusion. Also after brain injection, lymph and nodes contained more activity on injected side in contrast to lack of laterality after CSF administration. Calculation suggests that less than 30% of RISA cleared from brain can do so via a pool of well-mixed CSF. Analysis of tissues is compatible with much RISA draining by bulk flow via cerebral perivascular spaces plus passage from subarachnoid space of olfactory lobes into submucous spaces of nose and thus to lymph.

Brain vasopressin and sodium appetite

2002 ◽  
Vol 282 (4) ◽  
pp. R1236-R1244 ◽  
Author(s):  
Francis W. Flynn ◽  
Thomas R. Kirchner ◽  
Margaret E. Clinton
Keyword(s):  
Receptor Antagonist ◽  
Salt Intake ◽  
Antagonistic Activity ◽  
Intraventricular Injection ◽  
Salt Appetite ◽  
Sucrose Intake ◽  
Dramatic Decrease ◽  
Sodium Appetite ◽  
Arterial Blood ◽  
Intraventricular Injections

Intraventricular injections of vasopressin (VP) and antagonists with varying degrees of specificity for the VP receptors were used to identify the action of endogenous brain VP on 0.3 M NaCl intake by sodium-deficient rats. Lateral ventricular injections of 100 ng and 1 μg VP caused barrel rotations and a dramatic decrease in NaCl intake by sodium-deficient rats and suppressed sucrose intake. Intraventricular injection of the V1/V2 receptor antagonist [d(CH2)5 1,O-Et-Tyr2,Val4, Arg8]VP and the V1 receptor antagonist [d(CH2)5 1,O-Me-Tyr2,Arg8]VP (MeT-AVP) significantly suppressed NaCl intake by sodium-deficient rats without causing motor disturbances. MeT-AVP had no effect on sucrose intake (0.1 M). In contrast, the selective V2 receptor antagonist had no significant effect on NaCl intake. Last, injections of 100 ng MeT-AVP decreased mean arterial blood pressure (MAP), whereas 100 ng VP elevated MAP and pretreatment with MeT-AVP blocked the pressor effect of VP. These results indicate that the effects produced by 100 ng MeT-AVP represent receptor antagonistic activity. These findings suggest that the effect of exogenous VP on salt intake is secondary to motor disruptions and that endogenous brain VP neurotransmission acting at V1 receptors plays a role in the arousal of salt appetite.

scholarly journals Repeated intraventricular injections of ACTH 1–24: The effects of home or novel environments on excessive grooming

1978 ◽  
Vol 23 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Deborah L. Colbern ◽  
Robert L. Isaacson ◽  
Edward J. Green ◽  
Willem H. Gispen
Keyword(s):  
Intraventricular Injections ◽  
Novel Environments ◽  
Excessive Grooming
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