Effects of potassium channel inhibitors in the forced swimming test: Possible involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway

2005 ◽  
Vol 165 (2) ◽  
pp. 204-209 ◽  
Author(s):  
M KASTER ◽  
P FERREIRA ◽  
A SANTOS ◽  
A RODRIGUES
Keyword(s):  
Nitric Oxide ◽  
Potassium Channel ◽  
Guanylate Cyclase ◽  
Forced Swimming Test ◽  
Soluble Guanylate Cyclase ◽  
Forced Swimming ◽  
Swimming Test

Antidepressant-like effect of pioglitazone in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway

2011 ◽  
Vol 224 (2) ◽  
pp. 336-343 ◽  
Author(s):  
Mohammad Salehi Sadaghiani ◽  
Mehrak Javadi-Paydar ◽  
Mohammad Hadi Gharedaghi ◽  
Yashar Yousefzadeh Fard ◽  
Ahmad Reza Dehpour
Keyword(s):  
Nitric Oxide ◽  
Forced Swimming Test ◽  
Ppar Gamma ◽  
Forced Swimming ◽  
Gamma Receptor ◽  
Swimming Test ◽  
Nitric Oxide Pathway

Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test

2008 ◽  
Vol 18 (5) ◽  
pp. 323-332 ◽  
Author(s):  
Mehdi Ghasemi ◽  
Hamed Sadeghipour ◽  
Afsaneh Mosleh ◽  
Hamid Reza Sadeghipour ◽  
Ali Reza Mani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Swimming Test ◽  
Acute Lithium

Evidence for NO ⋅ redox form of nitric oxide as nitrergic inhibitory neurotransmitter in gut

1998 ◽  
Vol 275 (5) ◽  
pp. G1185-G1192 ◽  
Author(s):  
Raj K. Goyal ◽  
Xue D. He
Keyword(s):  
Nitric Oxide ◽  
Potassium Channel ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Slow Component ◽  
Circular Muscle ◽  
Exact Nature ◽  
Channel Blockers ◽  
Inhibitory Neurotransmitter ◽  
Ly 83583

A nitric oxide (NO)-like product of thel-arginine NO synthase pathway has been shown to be a major inhibitory neurotransmitter that is involved in the slow component of the inhibitory junction potential (IJP) elicited by stimulation of nonadrenergic, noncholinergic nerves. However, the exact nature of the nitrergic transmitter, the role of cGMP, and the involvement of a potassium or a chloride conductance in the slow IJP remain unresolved. We examined the effects of soluble guanylate cyclase inhibitors LY-83583 and 1 H-[1,2,4]oxadiazolo[4,3- a]quinoxalin-1-one (ODQ), potassium-channel blockers and putative chloride-channel blockers diphenylamine-2-carboxylate (DPC) and niflumic acid (NFA) on the hyperpolarization elicited by an NO ⋅ donor, diethylenetriamine/NO adduct (DNO), NO in solution, and an NO+ donor, sodium nitroprusside (SNP), in the guinea pig ileal circular muscle. Effects of these blockers on purinergic (fast) and nitrergic (slow) IJP were also examined. DNO-induced hyperpolarization and nitrergic slow IJP were suppressed by LY-83583 or ODQ and DPC or NFA but not by the potassium-channel blocker apamin. In contrast, hyperpolarization caused by SNP or solubilized NO gas and purinergic fast IJP were antagonized by apamin but not by inhibitors of guanylate cyclase or chloride channels. These results demonstrate biological differences in the actions of different redox states of NO and suggest that NO ⋅ is the nitrergic inhibitory neurotransmitter.

scholarly journals Involvement of nitric oxide–cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test

2005 ◽  
Vol 8 (04) ◽  
pp. 601 ◽  
Author(s):  
Manuella Pinto Kaster ◽  
Angelo Oscar Rosa ◽  
Adair R. S. Santos ◽  
Ana Lúcia S. Rodrigues
Keyword(s):  
Nitric Oxide ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Cgmp Pathway ◽  
Swimming Test
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